Navigation Links
Signal Genetics Announces Publication of Meta-Analysis of its Colon Cancer Test-Previstage™ GCC Confirming Prognostic Capabilities in Patients with Colon Cancer
Date:1/23/2012

NEW YORK, Jan. 23, 2012 /PRNewswire/ -- Signal Genetics, a privately held personalized medicine company focused on cancer, announced today the presentation of a paper entitled "Guanylyl Cyclase C (GCC) Lymph Nodes (LN) Classification as a Prognostic Marker in Patients with Stage II Colon Cancer: A Pooled Analysis" at the 2012 American Society of Clinical Oncology Gastrointestinal Cancer Symposium held in San Francisco, CA January 21, 2012.  The data from the paper demonstrate the value of implementing Previstage testing in patients with colorectal cancer to identify those patients at risk of relapse.

The paper is the culmination of the work conducted by a team of researchers and  collaborators from several  centers, including:  Rhode Island Hospital, Brown University, University of Massachusetts  Medical School, University of North Carolina, Lahey Clinic, Brigham and Women's Hospital, British Columbia Cancer Agency and DiagnoCure Inc.  These researchers conducted a pooled individual data analysis on 310 patients to confirm whether molecular detection of GCC in Lymph Nodes indicates high risk of disease recurrence and poor survival in untreated stage II colon cancer.

GCC is a colon-specific biomarker normally found in gastrointestinal epithelium whose expression is preserved in primary and metastatic colorectal cancer cells. Studies to date have suggested that the presence of GCC gene expression in lymph nodes increased the likelihood of disease recurrence in stage II colon cancer patients, independent of traditional high risk features. The results of this study suggest that detection of GCC mRNA in lymph nodes is associated with risk of disease recurrence in stage II colon cancer patients not treated with adjuvant chemotherapy.  These findings are consistent with several other studies conducted over the past 10 years.

Based on GCC levels, the estimated 5 year recurrence risks were 11% and 32%
'/>"/>

SOURCE Signal Genetics
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2

Related medicine technology :

1. Signal Genetics Announces Launch of Next Generation Genetic Multiple Myeloma Predictive Testing Product-MyPRS Plus™
2. New Gene Study of ADHD Points to Defects in Brain Signaling Pathways
3. USPTO Issues Patent for CardioGenics Signal Amplification Technology
4. Signal Genetics and DiagnoCure Announce a US$13.3M Collaboration for the Commercialization of Previstage™ GCC Colorectal Cancer Staging Test
5. Signal Genetics Announces Commercialization Partnership with NeoGenomics Laboratories for Multiple Myeloma Gene Expression Test
6. Quantum Signal and Delphinus Medical Technologies Awarded MEGA Funding to Expand in Ann Arbor Area
7. Debiopharm and EPFL Sign Research Project Agreement to Identify Inhibitors of Signalling Pathways Controlling Cell Fate for Cancer Treatment
8. SF1126, Semafores PI3 Kinase Inhibitor, Found to Block Angiogenic Signaling From Both VEGF and Bv8 in Multiple Cell Lines
9. Nature Publication Reports on Key Role of Bile Acids in Glucose Metabolism and Insulin Signaling
10. Device Blocking Stomach Nerve Signals Shows Promise in Obesity
11. Grocery Manufacturers Association: Study Signals Progress in Battle Against Obesity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... YORK, Pa. , Aug. 29, 2014  Unilife ...  ASX: UNS) announced today that it intends to release ... and year ended June 30, 2014 after market trading ... Management has scheduled a conference call for 4:30 p.m. ... 10, 2014 at 6:30 a.m. AEST), to review the Company,s ...
(Date:8/29/2014)... 2014  Abaxis, Inc. (NasdaqGS: ABAX ), ... consumables to the medical, research and veterinary markets, announced ... Executive Officer, will present at the CL King 12 ... September 9, 2014 at 12:30 p.m. ET. The conference ... in New York City . ...
(Date:8/29/2014)... 2014 Research and Markets  has announced ... Repair Devices Market 2014-2018" report to their offering. ... of cells that connect, support, or surround bones. There ... tendons, ligaments, cartilage, fascia, and other fibrous tissues. Repetitive ... with age result in wear and tear in these ...
Breaking Medicine Technology:Unilife Corporation to Announce Financial Results for Fiscal Year 2014 Fourth Quarter and Year End on Tuesday, September 9, 2014 2Abaxis, Inc. to Present at CL King's 12th Annual Best Ideas Conference 2014 2Global Orthopedic Soft Tissue Repair Devices Market 2014-2018: Key Vendors are ArthroCare, Biomet, DePuy Synthes and Smith & Nephew 2Global Orthopedic Soft Tissue Repair Devices Market 2014-2018: Key Vendors are ArthroCare, Biomet, DePuy Synthes and Smith & Nephew 3
... Oct. 7 Marine biotechnology specialist Azantis, Inc ... to its clients, in an effort to provide continued ... an agreement with SafetyCall International , Azantis has ... and Post-Market Surveillance services. SafetyCall medical ...
... Oct. 7 Spherix Incorporated (Nasdaq: ... in diabetes, metabolic syndrome and atherosclerosis; and providers of ... and pharmaceutical companies, today announced that it has entered ... its Series B Convertible Preferred Stock and warrants to ...
Cached Medicine Technology:Azantis Announces New Consumer Safety Program 2Spherix Announces Institutional Investors Purchase $5.25 Million of Convertible Preferred Stock and Warrants 2Spherix Announces Institutional Investors Purchase $5.25 Million of Convertible Preferred Stock and Warrants 3
(Date:9/2/2014)... 02, 2014 NOVAtime Technology, Inc. ... development company, announced today that Avon Health Center, ... upgraded to NOVAtime 4000 Time and Attendance ... NOVAtime’s latest smart clock, the NT7000 . ... of Connecticut is an award-winning nursing facility that ...
(Date:9/2/2014)... VA (PRWEB) September 02, 2014 During ... important to prepare for the winter months to prevent ... Northern Virginia real estate company, suggests these fall ... Clean gutters and downspouts frequently throughout fall to prevent ... can lead to wood rot problems, pest infestations, wet ...
(Date:9/1/2014)... September 02, 2014 Citrus Park ... root canal therapy based in Tampa, Florida, announced the ... features helpful information aimed at making the patient experience ... eye-catching design featuring updated images that truly make the ... our website experience just as pleasant as our office ...
(Date:9/1/2014)... September 02, 2014 PAINWeek, the National ... the American Pain Society (APS) will return to the ... expertise in pain management to the agenda. This activity ... no fee to attend this program. , On Thursday, ... activity that complies with the FDA’s Risk Evaluation and ...
(Date:9/1/2014)... September 02, 2014 UWDress.com, a well-known ... of 2014 lime green bridesmaid dresses for ... been added to the company’s online category. What’s more, ... 67% off. The special offer is specially launched to ... UWDress.com’s fashionable bridesmaid gowns have won great appreciation from ...
Breaking Medicine News(10 mins):Health News:Avon Healthcare Upgrades to NOVAtime 4000 Time and Attendance / Workforce Management Solution with NT7000 Smart Clocks 2Health News:Avon Healthcare Upgrades to NOVAtime 4000 Time and Attendance / Workforce Management Solution with NT7000 Smart Clocks 3Health News:Northern Virginia Real Estate Company Pasquali Realty Group Suggests These Maintenance Tips for Homeowners This Fall 2Health News:Citrus Park Endodontics Launches New Website to Better Serve Patients 2Health News:American Pain Society Returns with REMS Training at PAINWeek 2014 in Las Vegas 2Health News:2014 Lime Green Bridesmaid Dresses Offered At UWDress.com 2
... their families living with ... all types of epilepsy, ... series "Heroes" and father of an 11-year-old son with,epilepsy - joined ... community awareness activities that will empower other,people living with the condition. ...
... WASHINGTON, March 27 SEIU Spokesperson,Andrew ... members, resources, UHW-W leaders should focus ... contracts this year. UHW-W members,deserve better ... at risk by a distracted,UHW-W leadership.", ...
... DENVER, March 27 On March 25, 2008, ... the Gadolinium-Based Contrast,Agents Product Liability Multi-District Litigation in ... serve on the Plaintiffs, Steering,Committee. One of these ... PSC,reports directly to Judge Polster, and is responsible ...
... preferred it to product requiring three injections a day ... that a once-daily shot of insulin appears to control ... just as well as injecting insulin three times a ... (Lantus), is already on the market, as is insulin ...
... Ill., March 27 Lifeway Foods,Inc. (Nasdaq: LWAY ... of other natural and organic dairy products, is opening ... Starfruit in Chicago. The,shop will offer several flavors of ... kefir parfaits, and smoothie-style kefir drinks., The new ...
... you know that teledentistry can help provide orthodontic treatment ... provide diagnostic clues to your systemic health? Have you ... growth with other metabolic processes?, These are but a ... will be presented when the American Association for Dental ...
Cached Medicine News:Health News:Once-Daily Insulin Shot Proves Effective in Study 2Health News:Once-Daily Insulin Shot Proves Effective in Study 3Health News:Lifeway Foods Launches Starfruit, New 'Kefir Boutique' Cafe Selling Frozen Kefir & Kefir Smoothies 2Health News:Dental scientists convene in Dallas 2Health News:Dental scientists convene in Dallas 3Health News:Dental scientists convene in Dallas 4
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: