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Sigma-Aldrich Enters Distribution Agreement With Stemgent, Inc. to Offer Lentivirus-Based Gene Delivery Products for Regenerative Medicine and Stem Cell Research
Date:11/10/2009

ST. LOUIS, Nov. 10 /PRNewswire-FirstCall/ -- Sigma-Aldrich® (Nasdaq: SIAL) today announced that it has entered into an exclusive worldwide distribution agreement with Stemgent, Inc. to offer Stemgent's portfolio of lentivirus-based delivery systems for the generation of induced pluripotent stem (iPS) cells. This agreement expands Sigma-Aldrich's leading portfolio of advanced stem cell research technologies, available through the Company's web portal at http://www.sigma-aldrich.com/stemcell.

"Induced pluripotent stem cells have emerged as immensely useful tools for the modeling of human diseases, research and development of therapeutics, regenerative medicine and the development of personalized cell replacement therapies," commented Dr. David Smoller, Ph.D, President of Sigma-Aldrich's Research Biotech business unit. "Stemgent has made great strides developing lentivirus-based gene delivery vectors, and Sigma-Aldrich has made it a priority to provide products and services for the iPS cell research community."

Through Sigma-Aldrich's worldwide market and customer service infrastructure, Stemgent can access a wider audience for its sophisticated tools. The reprogramming technologies offered under the terms of the agreement involve proprietary viral vectors from Stemgent, lentivirus technology from Sigma-Aldrich and Dox Inducible expression from TET Systems. These technologies have been fully validated in Stemgent's laboratories and are expected to allow researchers to efficiently reprogram mouse and human cells into iPS cells, enabling researchers to investigate and address the challenges facing the field of regenerative medicine.

"We are excited to enter into a partnership with Sigma-Aldrich," added Stemgent CEO Ian Ratcliffe. "We believe that the lentiv
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