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Sigma-Aldrich Corporation's Sigma Life Science Business to Distribute Worldwide Olink Bioscience's Protein Interaction Analysis Technology
Date:2/12/2013

target pair of proteins are in close proximity—can hybridize to trigger a rolling circle amplification reaction. Fluorescent detection probes bind the several hundred-fold amplified DNA at high density, allowing visualization of single protein–protein interactions inside an intact cell using a standard fluorescence microscope.

"The ability to visualize these protein-protein interactions in unmodified cells under endogenous expression and at very low levels is a fundamental advance that allows greater insight into basic biology, pathways, spatial phenomena and potential therapeutic targets in those pathways," said Zihlmann.

More than 350 publications in the past six years have relied upon the Duolink method, which is featured in an average of five publications per week by academic and pharmaceutical researchers. The Sigma Life Science Prestige® antibody collection complements the technology with its portfolio of more than 14,000 antibodies that have been validated by immunohistochemistry, a key requirement for Duolink In Situ products to target specific proteins of interest.

"We believe the agreement with Sigma Life Science will build awareness and develop the market for Duolink In Situ through their global sales and support organization serving our growing customer base locally," said Simon Fredriksson , CEO and President of Olink Bioscience. "Sigma Life Science's extensive product range for cell biology is a perfect context for customers interested in Duolink In Situ."

For more information, visit www.sigma.com/duolink.

Cautionary Statement: The foregoing release contains forward-looking statements that can be identified by terminology such as "disruptive," "robust," "fundamental advance," "greater insight" or similar expressions, or by expressed or implied discussions regarding potential future revenues from products derive
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SOURCE Sigma-Aldrich Corporation
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