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Sigma-Aldrich(R) Receives Award From Michael J. Fox Foundation to Develop Parkinson's Disease Research Models
Date:10/1/2009

d to facilitate the development of new models that scientists believe will provide a better understanding of Parkinson's disease at the molecular, biochemical, physiological and behavioral levels. This knowledge may, in turn, result in new therapeutic targets and approaches for the treatment of Parkinson's disease.

"Our Foundation's mission is to accelerate the conversion of basic discoveries about Parkinson's disease into practical treatments that will make a difference in patients' lives," said Katie Hood, CEO of The Michael J. Fox Foundation. "To accomplish this, there is a critical need for new research models to more effectively screen potential new therapies, particularly neuroprotective therapies. We're excited about the knockout rat technology developed by Sigma-Aldrich, and hopeful for its prospects to quickly make a major impact on Parkinson's disease drug development efforts and help deliver breakthrough treatments to patients faster."

"The work undertaken and funding provided by The Michael J. Fox Foundation is fundamental to the scientific community's ability to get one step closer to the next generation of Parkinson's disease treatments," added Dr. Edward Weinstein, Director of SAGE Labs at Sigma-Aldrich. "With the power of our CompoZr technology, we are able provide a unique and innovative contribution to furthering research into this debilitating disorder. The models that we are developing may one day help in the development of new therapeutic approaches to a number of diseases. We are excited to have an opportunity to advance scientific understanding in areas that can directly improve the lives of those that suffer with this disease."

Because rats are physiologically similar to humans, they are ideal subjects for modeling human diseases and have been an important species for research in a number of fields including physiology, endocrinology, neurology, toxicology and cancer. Until recently it has been impossible to c
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