Navigation Links
Sigma® Life Science Launches CompoZr® Targeted Integration Kit - mRosa26 for the Mouse Genome
Date:7/19/2011

ST. LOUIS, July 19, 2011 /PRNewswire/ -- Sigma Life Science, the innovative biological products and services research business of Sigma-Aldrich Corporation (Nasdaq: SIAL) today announced the launch of CompoZr Targeted Integration Kit – mRosa26, which can precisely and rapidly integrate transgenes into the mouse genome at the Rosa26 safe harbor locus. This kit follows the introduction of the CompoZr Targeted Integration Kit – AAVS1, for transgene integration in the human genome. For additional information on both kits, visit sigma.com/targetedkit.

Traditional transgenic approaches rely on random integration of a transgene. This low efficiency approach results in multiple random integration events at off-target insertion sites, and often requires the use of antibiotic selection strategies. In addition, the integration event can involve multiple copies of the transgene. Using the CompoZr ZFN technology, a single copy of a transgene can be targeted and inserted in the Rosa26 locus, which is a well-defined safe harbor site in the mouse genome. Sigma's CompoZr Targeted Integration Kits use zinc finger nucleases (ZFNs) for precise and heritable gene knockin at the target locus (Rosa26 or AAVS1). Both Human and Mouse kits are supplied with the necessary ZFNs and donor plasmid to successfully perform transgene integration by ZFN-assisted homologous recombination, reducing the timescale and complexity of engineering transgenic mouse and human cell lines.

"ZFN mediated transgene integration using Sigma's CompoZr Targeted Integration Kit – mRosa26 represents the most efficient method for targeted transgene integration at the highly characterized Rosa26 locus of the mouse genome," said Dr. Supriya Shivakumar, Global Commercial Marketing Manager for Functional Genomics at Sigma Life Science. "This latest release is part of Sigma's ongoing objective to increase the
'/>"/>

SOURCE Sigma-Aldrich
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Magellan Biosciences Sells TREK Microbiology Business to Thermo Fisher Scientific
2. Caliper Life Sciences to Ring The NASDAQ Stock Market Opening Bell on Tuesday, July 19
3. Coronado Biosciences Files to Become a Public Reporting Company
4. SARcode Bioscience Completes $44 Million Series B Financing
5. Convergen LifeSciences Announces Patent Award
6. Particle Sciences and Absorption Systems Form Relationship to Offer their Clients Enhanced Services
7. USANA Health Sciences Is Now an FDA-Registered Facility
8. HUYA BIOSCIENCE INTERNATIONAL ENGAGES IN PARTNERSHIP WITH LIAONING (BENXI) BIO-PHARMACEUTICAL INDUSTRY BASE
9. Cardiac Science Gains Japanese Regulatory Approval for Powerheart AED
10. Coronado Biosciences Closes $25.8M in Series C Financing
11. Tibotec Pharmaceuticals Announces Agreement With Gilead Sciences to Develop and Commercialize a New Fixed-Dose Combination of PREZISTA® and Cobicistat
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/27/2015)... , March 27, 2015  The quality function ... description: ensure products meet quality standards at every stage ... escalating regulations, quality leaders also have the challenge of ... Those who don,t effectively balance these priorities ... well as marketplace failure and regulatory scrutiny. ...
(Date:3/27/2015)... 27, 2015 /PRNewswire/ - Medicure Inc. (the "Company") (TSXV:MPH, ... approved the grant of an aggregate of 236,070 options ... consultants of the Company pursuant to the Company,s Stock ... expire on the tenth anniversary of the date of ... anniversary of the date of grant and 50,000 are ...
(Date:3/27/2015)... , March 27, 2015 Biopharmaceutical Industry ... biopharmaceutical industry comes out on top as the country,s ... new report  from ndp│analytics. According to the  analysis ... (R&D) investment over the last decade, accounting for 27 ... A Short Video on Medicare Part ...
Breaking Medicine Technology:New Medical Device Quality Study Finds Regulatory Environment is Boosting Quality Spending, Especially for Large Companies 2Week in Review: The Latest from PhRMA 2
... March 15, 2012 Reportlinker.com announces that ... in its catalogue: ... http://www.reportlinker.com/p0578259/Vaccines---Asia.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Drug_and_Medication This market research report ... actual market situation, trends and future outlook ...
... March 14, 2012 Brainlab wins coveted ,red dot ... world submitted 4,515 designs altogether to the international product ... received the globally sought after red dot in product ... technology. This advanced surgical navigation system for the brain ...
Cached Medicine Technology:Vaccines - Asia 2Brainlab Curve Wins Coveted Red Dot Award: Product Design 2012 2Brainlab Curve Wins Coveted Red Dot Award: Product Design 2012 3
(Date:3/27/2015)... Omaha, NE (PRWEB) March 27, 2015 Ticket ... tickets at the CenturyLink Center in Omaha, Nebraska on ... a possibility that more concert dates will be added in ... result of fan demand. , The Garth Brooks World Tour ... with the latest announcement that Garth Brooks and Trisha Yearwood ...
(Date:3/27/2015)... LONDON, UK (PRWEB) March 27, 2015 ... SiteStart Melissa (Liss) Easy was named to the 2015 ... 40 Under 40 list spotlights 40 dynamic, up-and-coming leaders ... accomplishments and community involvement. Winners are honored at an ... supplement of the Philadelphia Business Journal. , Lyn Kremer, ...
(Date:3/27/2015)... Francisco, CA (PRWEB) March 27, 2015 ... Recovery Yoga for functional fitness athletes. This new program ... a specific protocol for post-workout cool down. This program ... promote breath control and mental focus. , Karen ... “I started practicing yoga long before I started Crossfit® ...
(Date:3/27/2015)... According to Health Day , on ... Abstinence Syndrome (NAS) are causing alarm for Florida officials. ... process for a month of their lives- and can ... vomiting. The condition is precipitated by drug use during ... (and employing medically assisted drug treatment) will also inflict ...
(Date:3/27/2015)... SMI (Silicon Microstructures, Inc.), a global MEMS pressure ... MEMS based ultra-miniature pressure sensor designed especially for the ... 220um x 75um provides ample space for 1-French catheter ... industry leading in vivo drift performance of 2 ... pressure range from 0 to 1,100 mmHg absolute. ...
Breaking Medicine News(10 mins):Health News:Cheap Garth Brooks Tickets for CenturyLink Center in Omaha: Ticket Down Slashes Garth Brooks Concert Tickets in Omaha, NE at the CenturyLink Center 2Health News:Cheap Garth Brooks Tickets for CenturyLink Center in Omaha: Ticket Down Slashes Garth Brooks Concert Tickets in Omaha, NE at the CenturyLink Center 3Health News:DrugDev Founder Melissa Easy is 2015 Philadelphia Business Journal 40 Under 40 Honoree 2Health News:Endure Yoga Introduces WOD Recovery Yoga 2Health News:In Florida Only 10% of Pregnant Mothers Are Referred to Drug Rehab Despite Testing Positive for Narcotics 2Health News:SMI Launches Catheter Mountable Pressure Sensor 2
... ... and online universities can be time consuming, confusing, and intimidating for adults going back to ... Equalizer, a new revolutionary college search and counseling service is about to change all that. ... Tampa, Florida (PRWEB) June ...
... Almost three quarters (72%) of women with Rheumatoid Arthritis (RA) ... receive pain relief medication, according to a new study presented ... League Against Rheumatism in Rome, Italy. Furthermore the physical ... it impacts negatively on emotional and social aspects of their ...
... ... Message of Hope , , ... 16, 2010 -- As Father’s Day approaches many men are looking forward to gifts of hand-made ... love of their children. And for those men who are trying to become dads, the ...
... connectedness, research shows , WEDNESDAY, June 16 (HealthDay News) -- If ... Slovenia in its next World Cup match on Friday, know that ... lot of fun. , Scientists have shown that fans who feel ... and cheer along with like-minded fans, reap the mental health benefits ...
... ... first SottoPelle® medical clinic in Middle Tennessee. Dr. Tutera is a pioneer in an ... levels to authentically regulate the release of hormones. , ... Nashville, Tenn. (PRWEB) June 16, 2010 -- Gino ...
... Positioning ... ... Enovate , a leading provider of mobile and wall-mounted computer workstations, announced today ... American healthcare markets. Similar to the United States, the healthcare industry abroad is moving ...
Cached Medicine News:Health News:Comparing Tuition and Fees Just Got Easier With College Equalizer, the New Revolutionary College Search System Set to Launch Soon 2Health News:Comparing Tuition and Fees Just Got Easier With College Equalizer, the New Revolutionary College Search System Set to Launch Soon 3Health News:Almost three quarters of women with rheumatoid arthritis worldwide suffer pain daily 2Health News:7.3 Million US Men and Their Partners Face Fertility Issues 2Health News:7.3 Million US Men and Their Partners Face Fertility Issues 3Health News:World Cup Matches Might Boost Your Mental Health 2Health News:World Cup Matches Might Boost Your Mental Health 3Health News:World Cup Matches Might Boost Your Mental Health 4Health News:Gino Tutera, M.D., F.A.C.O.G. Brings SottoPelle Therapy to Middle Tennessee, Opens Practice in Nashville Medical District 2Health News:Enovate Announces Global Expansion 2
... digital single plane C-arm angiography system is ... performance and an expansive range of diagnostic ... to ECG triggered. ... of the art dynamic Flat Detector technology, ...
... Meta-4 Computerized ENG utilizes a ... comprehensive nystagmus and ocular motor ... storage, data analysis and reanalysis ... data in the Meta-4 software ...
Stryker Leibinger offers a variety of different Titanium Implant Systems and special instrument sets, which enable our customers to treat a wide range of indication...
Stryker Leibinger offers a variety of different Titanium Implant Systems and special instrument sets, which enable our customers to treat a wide range of indication...
Medicine Products: