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Shire Second Quarter Product Sales Up 16%
Date:8/1/2012

d Quarter 2012 Financial Results 7 Financial Information 11 Non GAAP Reconciliations 20 Notes to Editors 25 Safe Harbor Statement 25 Explanation of Non GAAP Measures 25 Trademarks 26


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OVERVIEW OF SECOND QUARTER 2012 FINANCIAL RESULTS

1.    Product sales

For the three months to June 30, 2012 product sales increased by 16% to $1,148 million (Q2 2011: $993 million) and represented 95% of total revenues (Q2 2011: 93%).

US Exit Market Product Highlights Year on year growth Share(1) Product Sales $M Sales CER US Rx(1) VYVANSE 266.2 +43% +43% +19% 16% ADDERALL XR 133.9 -9% -9% -13% 6% REPLAGAL(R) 123.2 +3% +11% n/a(3) n/a(3) ELAPRASE(R) 122.2 -4% +2% n/a(2) n/a(2) LIALDA/MEZAVANT(R) 94.1 -5% -4% +6% 22% VPRIV 82.7 +31% +35% n/a(2) n/a(2) INTUNIV 69.1 +16% +16% +39% 5% PENTASA(R) 63.9 -3% -3% -5% 14% DERMAGRAFT 52.4 n/a n/a n/a(2) n/a(2) FOSRENOL(R) 43.2 -5% -1% -19% 5% FIRAZYR 31.7 +466% +482% n/a(2) n/a(2) OTHER 65.1 -10% -4% n/a n/a Total product sales 1,147.7 +16% +18% (1) Data provided by IMS Health National Prescription Audit ("IMS NPA"). Exit market share represents the average monthly US market share in the month ended June 30, 2012. (2) IMS NPA Data not available. (3) Not sold in the US in Q2 2012.

VYVANSE - ADHD

VYVANSE product sales grew strongly in Q2 2012, up 43% compared to
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