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Shire Second Quarter Product Sales Up 16%
Date:8/1/2012

RANA contingent
    consideration to fair value ($3.5 million), reorganization costs ($13.0 million) on
    the transfer of manufacturing from Owings Mills to a third party and the
    establishment of an international commercial hub in Switzerland, and tax effect of
    adjustments; and

(d) Depreciation reclassification: Depreciation of $54.3 million included in Cost of
    product sales, R&D costs and SG&A costs for US GAAP separately disclosed for the
    presentation of Non GAAP earnings.


Unaudited results for the three months and six months to June 30, 2012

Non GAAP reconciliation

The following table reconciles US GAAP net cash provided by operating activities to Non GAAP cash generation:

3 months to June 30, 6 months to June 30, 2012 2011 2012 2011 $M $M $M $M Net cash provided by operating activities 465.8 283.6 722.8 485.5 Tax and interest payments, net 54.4 156.4 84.2 162.8 Up-front payments in respect of in-licensed and acquired products - - 23.0 - Non GAAP cash generation 520.2 440.0 830.0 648.3

The following table reconciles US GAAP net cash provided by operating activities to Non GAAP free cash flow:

3 months to June 30, 6 months to June 30, 2012 2011 2012 2011 $M $M $M $M Net cash provided by operating activities 465.8 283.6 722.8 485.5 Up-front payments in respect of in-licensed and acquired products - - 23.0 - Capital expenditure (32.7) (48.5) (64.4) (95.0) Non GAAP free cash flow 433.1 235.1 681.4 390.5

Non GAAP net cash/(debt) comprises:

June 30, December 31, 2012 2011 $M $M Cash and cash equivalents 1,112.7 620.0 Restricted cash 14.4 20.6 Convertible bonds (1,100.0) (1,100.0) Other (9.5) (8.2) Non GAAP net cash/(debt) 17.6 (467.6)

NOTES TO EDITORS

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SOURCE Shire plc
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