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Shire Second Quarter Product Sales Up 16%
Date:8/1/2012

amp;A 843.2 (72.7) - - (29.7) 740.8 Loss on sale of product rights 3.5 - - (3.5) - - Reorganization costs 13.0 - - (13.0) - - Integration and acquisition costs 2.6 - (2.6) - - - Depreciation - - - - 54.3 54.3 Total operating expenses 1,485.3 (72.7) (2.6) (22.1) - 1,387.9 Operating income 549.8 72.7 2.6 22.1 - 647.2 Interest income 1.2 - - - - 1.2 Interest expense (19.1) - - - - (19.1) Other income, net 0.3 2.4 - - - 2.7 Total other expense, net (17.6) 2.4 - - - (15.2) Income before income taxes and equity in earnings of equity method investees 532.2 75.1 2.6 22.1 - 632.0 Income taxes (117.8) (15.8) (4.9) (4.4) - (142.9) Equity in earnings of equity method investees, net of tax 2.4 - - - - 2.4 Net income 416.8 59.3 (2.3) 17.7 - 491.5 Impact of convertible debt, net of tax 16.8 - - - - 16.8 Numerator for diluted EPS 433.6 59.3 (2.3) 17.7 - 508.3 Weighted average number of shares (millions) - diluted 594.8 - - - - 594.8 Diluted earnings per ADS 218.7c 29.9c (1.1c) 8.9c - 256.4c

The following items are included in Adjustments:

(a) Amortization and asset impairments: Amortization of intangible assets relating to
    intellectual property rights acquired ($72.7 million), impairment of available for
    sale securities ($2.4 million), and tax effect of adjustments;

(b) Acquisitions and integration activities: Costs associated with acquisition and
    integration of ABH ($6.9 million) and integration of Movetis ($3.9 million),
    adjustment to contingent consideration payable for EQUASYM ($8.2 million), and tax
    effect of adjustments;

(c) Divestments, reorganizations and discontinued operations: Accelerated depreciation
    ($4.4 million) and dual running costs ($1.2 million) on the transfer of manufacturing
    from Owings Mills to a third party, re-measurement of DAYT
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SOURCE Shire plc
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