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Shire Second Quarter Product Sales Up 16%
Date:8/1/2012

nings per ADS 248.4c 48.3c 13.2c (5.4c) 11.7c - 316.2c

The following items are included in Adjustments:

(a) Amortization and asset impairments: Impairment of certain IPR&D intangible assets
    ($27.0 million), amortization of intangible assets relating to intellectual property
    rights acquired ($96.6 million), and tax effect of adjustments;

(b) Acquisitions and integration activities: Up-front payments made to Sangamo Biosciences
    Inc. and for the acquisition of the US rights to prucalopride (marketed in certain
    countries in Europe as RESOLOR) ($23.0 million), costs associated with acquisition of
    FerroKin and the integration of ABH ($10.3 million), charges related to the change in
    fair value of deferred contingent consideration ($2.1 million), and tax effect of
    adjustments;

(c) Divestments, reorganizations and discontinued operations: Re-measurement of DAYTRANA
    contingent consideration to fair value ($10.8 million);

(d) Legal and litigation costs: Costs related to the settlement of litigation and external
    legal costs ($35.9 million), and tax effect of adjustments; and

(e) Depreciation reclassification: Depreciation of $55.1 million included in Cost of
    product sales, R&D costs and SG&A costs for US GAAP separately disclosed for the
    presentation of Non GAAP earnings.


Unaudited results for the six months to June 30, 2011

Non GAAP reconciliation

6 months to June 30, 2011 US GAAP Adjustments Non GAAP (a) (b) (c) (d) $M $M $M $M $M $M Total revenues 2,035.1 - - - - 2,035.1 Costs and expenses: Cost of product sales 268.2 - - (5.6) (13.8) 248.8 R&D 354.8 - - - (10.8) 344.0 SG&
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SOURCE Shire plc
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