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Shire Second Quarter Product Sales Up 16%
Date:8/1/2012

gs Mills to a third party, re-measurement of DAYTRANA contingent
    consideration to fair value ($2.2 million), reorganization costs ($7.5 million) on the
    transfer of manufacturing from Owings Mills to a third party and establishment of an
    international commercial hub in Switzerland, and tax effect of adjustments; and

(d) Depreciation reclassification: Depreciation of $29.5 million included in Cost of
    product sales, R&D costs and SG&A costs for US GAAP separately disclosed for the
    presentation of Non GAAP earnings.


Unaudited results for the six months to June 30, 2012

Non GAAP reconciliation

6 months to June 30, US Non 2012 GAAP Adjustments GAAP (a) (b) (c) (d) (e) $M $M $M $M $M $M $M Total revenues 2,379.6 - - - - - 2,379.6 Costs and expenses: Cost of product sales 310.9 - - - - (14.2) 296.7 R&D 458.9 (27.0) (23.0) - - (12.8) 396.1 SG&A 1,011.0 (96.6) - - (35.9) (28.1) 850.4 Gain on sale of product rights (10.8) - - 10.8 - - - Integration and acquisition costs 12.4 - (12.4) - - - - Depreciation - - - - - 55.1 55.1 Total operating expenses 1,782.4 (123.6) (35.4) 10.8 (35.9) - 1,598.3 Operating income 597.2 123.6 35.4 (10.8) 35.9 - 781.3 Interest income 1.4 - - - - - 1.4 Interest expense (19.8) - - - - - (19.8) Other income, net 0.1 - - - - - 0.1 Total other expense, net (18.3) - - - - - (18.3) Income before income taxes and equity in earnings of equity method investees 578.9 123.6 35.4 (10.8) 35.9 - 763.0 Income taxes (103.0) (27.7) (9.0) - (13.0) - (152.7) Equity in earnings of equity method investees, net of tax 0.3 - - - - - 0.3 Net income 476.2 95.9 26.4 (10.8) 22.9 - 610.6 Impact of convertible debt, net of tax 16.2 - - - - - 16.2 Numerator for diluted EPS 492.4 95.9 26.4 (10.8) 22.9 - 626.8 Weighted average number of shares (millions) - diluted 594.8 - - - - - 594.8 Diluted ear
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