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Shire Second Quarter Product Sales Up 16%
Date:8/1/2012

60;three months to June 30, 2011

Non GAAP reconciliation

3 months to June 30, 2011 US GAAP Adjustments Non GAAP (a) (b) (c) (d) $M $M $M $M $M $M Total revenues 1,062.9 - - - - 1,062.9 Costs and expenses: Cost of product sales 143.7 - - (2.8) (8.3) 132.6 R&D 176.9 - - - (6.1) 170.8 SG&A 440.3 (36.7) - - (15.1) 388.5 Loss on sale of product rights 2.2 - - (2.2) - - Reorganization costs 7.5 - - (7.5) - - Integration and acquisition costs 9.0 - (9.0) - - - Depreciation - - - - 29.5 29.5 Total operating expenses 779.6 (36.7) (9.0) (12.5) - 721.4 Operating income 283.3 36.7 9.0 12.5 - 341.5 Interest income 0.6 - - - - 0.6 Interest expense (9.9) - - - - (9.9) Total other expense, net (9.3) - - - - (9.3) Income before income taxes and equity in earnings of equity method investees 274.0 36.7 9.0 12.5 - 332.2 Income taxes (69.7) (3.9) (1.1) (2.4) - (77.1) Equity in earnings of equity method investees, net of tax 1.2 - - - - 1.2 Net income 205.5 32.8 7.9 10.1 - 256.3 Impact of convertible debt, net of tax 8.4 - - - - 8.4 Numerator for diluted EPS 213.9 32.8 7.9 10.1 - 264.7 Weighted average number of shares (millions) - diluted 595.1 - - - - 595.1 Diluted earnings per ADS 107.7c 16.5c 4.1c 5.1c - 133.4c

The following items are included in Adjustments:

(a) Amortization and asset impairments: Amortization of intangible assets relating to
    intellectual property rights acquired ($36.7 million), and tax effect of adjustment;

(b) Acquisition and Integration activities: Costs associated with the acquisition of ABH
    ($6.9 million) and integration of Movetis ($2.1 million), and tax effect of
    adjustments;

(c) Divestments, reorganizations and discontinued operations: Accelerated depreciation
    ($2.2 million) and dual running costs ($0.6 million) on the transfer of manufacturing
    from Owin
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SOURCE Shire plc
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