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Shire Second Quarter Product Sales Up 16%
Date:8/1/2012


Unaudited US GAAP results for the six months to June 30, 2012

Selected Notes to the Financial Statements

(2)  Analysis of revenues

6 months to June 30, 2012 2011 2012 2012 % % of total $M $M change revenue Net product sales: SP BH VYVANSE 526.2 388.2 36% 22% ADDERALL XR 245.3 258.1 -5% 10% INTUNIV 137.6 101.5 36% 6% EQUASYM 15.8 10.5 50% <1% 924.9 758.3 22% 39% GI LIALDA/MEZAVANT 184.1 186.3 -1% 8% PENTASA 129.7 130.3 <1% 5% RESOLOR 5.5 2.5 120% <1% 319.3 319.1 <1% 13% General products FOSRENOL 88.7 86.5 3% 4% XAGRID 48.7 45.9 6% 2% 137.4 132.4 4% 6% Other product sales 60.6 81.0 -25% 3% Total SP product sales 1,442.2 1,290.8 12% 61% HGT REPLAGAL 257.6 225.3 14% 11% ELAPRASE 247.8 231.3 7% 10% VPRIV 154.4 122.3 26% 7% FIRAZYR 51.4 10.9 372% 2% Total HGT product sales 711.2 589.8 21% 30% RM DERMAGRAFT 101.2 2.0 n/a 4% Total RM product sales 101.2 2.0 n/a 4% Total product sales 2,254.6 1,882.6 20% 95% Royalties: ADDERALL XR 51.0 43.7 17% 2% 3TC and ZEFFIX 24.2 46.8 -48% 1% FOSRENOL 23.0 20.5 12% 1% Other 14.4 26.0 -45% <1% Total royalties 112.6 137.0 -18% 5% Other revenues 12.4 15.5 -20% <1% Total revenues 2,379.6 2,035.1 17% 100%

Unaudited results for the three months to June 30, 2012

Non GAAP reconciliation

3 months to June 30, 2012 US GAAP Adjustments Non GAAP (a) (b) (c) (d) (e) $M $M $M $M $M $M $M Total revenues 1,207.8 - - - - - 1,207.8 Costs and expenses: Cost of product sales 152.5 - - - - (7.0) 145.5 R&D 238.6 (27.0) - - - (6.4) 205.2 SG&A 511.0 (51.0) - - (35.9) (14.5) 409.6 Gain on sale of product rights (3.6) - - 3.6 - - - Integration and acquisition costs 7.1 - (7.1) - - - - Depreciation - - - - - 27.9 27.9 Total operating expenses 905.6 (78.0) (7.1) 3.6 (35.9) - 788.2 Operating income 302.2 78.0 7.1 (3.6) 35.9 - 419.6 Interest income 0.6 - - - - - 0.6 Interest expense (9.6) - - - - - (9.6) Other expense, net (1.8) - - - - - (1.8) Total
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SOURCE Shire plc
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