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Shire Second Quarter Product Sales Up 16%
Date:8/1/2012

e "if converted" method.

The share equivalents not included in the calculation of the diluted weighted average number of shares are shown below:

3 months to 3 months to 6 months to 6 months to June 30, June 30, June 30, June 30, 2012 2011 2012 2011 Millions Millions Millions Millions Share based awards to employees(1) 6.3 2.9 4.5 3.8

  1. Certain stock options have been excluded from the calculation of diluted EPS because (a) their exercise prices exceeded Shire's average share price during the calculation period or (b) the required performance conditions were not satisfied as at the balance sheet date.

 


Unaudited US GAAP results for the three months to June 30, 2012

Selected Notes to the Financial Statements

(2)  Analysis of revenues

3 months to June 30, 2012 2011 2012 2012 % % of total $M $M change revenue Net product sales: Specialty Pharmaceuticals ("SP") BH VYVANSE 266.2 185.9 43% 22% ADDERALL XR 133.9 146.9 -9% 11% INTUNIV 69.1 59.6 16% 6% EQUASYM(R) 8.6 5.9 46% 1% 477.8 398.3 20% 40% Gastro Intestinal ("GI") LIALDA/MEZAVANT 94.1 99.2 -5% 8% PENTASA 63.9 65.8 -3% 5% RESOLOR 3.1 1.6 94% <1% 161.1 166.6 -3% 13% General products FOSRENOL 43.2 45.3 -5% 4% XAGRID(R) 25.5 23.2 10% 2% 68.7 68.5 <1% 6% Other product sales 27.9 41.3 -32% 2% Total SP product sales 735.5 674.7 9% 61% Human Genetic Therapies ("HGT") REPLAGAL 123.2 119.9 3% 10% ELAPRASE 122.2 127.8 -4% 10% VPRIV 82.7 63.3 31% 7% FIRAZYR 31.7 5.6 466% 3% Total HGT product sales 359.8 316.6 14% 30% Regenerative Medicine ("RM") DERMAGRAFT 52.4 2.0 n/a 4% Total RM product sales 52.4 2.0 n/a 4% Total product sales 1,147.7 993.3 16% 95% Royalties: ADDERALL XR 25.7 26.9 -5% 2% FOSRENOL 13.0 12.4 5% 1% 3TC and ZEFFIX 10.6 11.3 -6% 1% Other 7.0 12.8 -45% <1% Total royalties 56.3 63.4 -11% 5% Other revenues 3.8 6.2 -39% <1% Total revenues 1,207.8 1,062.9 14% 100%

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SOURCE Shire plc
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