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Shire Second Quarter Product Sales Up 16%
Date:8/1/2012

ntinue to see both good growth in new patients starting treatment and promising levels of repeat usage by existing patients. The more established markets in Europe also continue to grow following the approval of self administration in Q1 2011.

2.    Royalties

Year on year growth Royalties to Product Shire $M Royalties CER ADDERALL XR 1.00 25.7 -5% -5% FOSRENOL 1.00 13.0 5% 5% 3TC(R) and ZEFFIX(R) 1.00 10.6 -6% -7% Other 1.00 7.0 -45% -42% Total 1.00 56.3 -11% -11%

3.    Financial details

Cost of product sales

% of % of product product Q2 2012 sales Q2 2011 sales $M $M Cost of product sales (US GAAP) 152.5 13% 143.7 14% Transfer of manufacturing from Owings Mills - (2.8) Depreciation (7.0) (8.3) Cost of product sales (Non GAAP) 145.5 13% 132.6 13%

Non GAAP cost of product sales as a percentage of product sales remained constant as the effect of slightly higher gross margins from our Behavioral Health ("BH") products were marginally diluted by the addition of lower margin DERMAGRAFT following the acquisition of ABH in Q2 2011.

R&D

% of % of product product Q2 2012 sales Q2 2011 sales $M $M R&D (US GAAP) 238.6 21% 176.9 18% Impairment of intangible assets (27.0) - Depreciation (6.4) (6.1) R&D (Non GAAP) 205.2 18% 170.8 17%

Non GAAP R&D grew by $34.4 million, or 20%, due to increased investment in a number of targeted R&D programs including the VYVANSE MDD program, new programs acquired with FerroKin and from Pervasis, and the inclusion of a full quarter's R&D costs for ABH. On a CER basis Non GAAP R&D increased by approximately 25% as Q2 2012 benefited from favorable foreign exchange compared to Q2 2011.

US GAAP R&D increased by $61.7 million, or 35%, as Q2 2012 included impairment charges relating to certain IPR&D intangible assets.

SG&A

% of % of product product Q2 2012 sales Q
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SOURCE Shire plc
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