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Shire Presents Results of Five Lialda(R) (mesalamine) Analyses at ACG 2009 Annual Scientific Meeting
Date:10/26/2009

balsalazide disodium and Colazal]; and Dipentum patients (500mg) (n=126) were 36 and 27 percent persistent (continuing). A total of 19,398 patients were identified as persistent (continuing) patients after three months of therapy and were included in this analysis.

Persistent (continuing) patients were defined as those who refilled their prescription within a period of up to twice the duration of the prescription that preceded the refill. Restart patients were defined as those who refilled their prescription after the grace period of twice the duration of their prescription had elapsed. Refill records for patients who were considered persistent (continuing) over the initial 3 months of treatment were analyzed at 12 and 18 months. This database analysis was neither designed nor intended to compare the safety and efficacy of the 5-ASA products and no such conclusions can be drawn from its results.

Lialda is an FDA-approved, once-daily oral medication for the induction of remission in patients with active, mild to moderate UC. The safety and effectiveness of Lialda beyond eight weeks have not been established.

Continuing Persistence with Mesalamine Therapy: Results from Patients Persistent with Long-term Therapy

Poster Presentation: October 25, 2009, San Diego Convention Center (#292)

A long-term persistency analysis evaluated patients who were persistent (continuing) at month 12 and followed them for an additional six months. At month 18, results showed 66 percent were persistent (continuing) with Lialda (n=1,247), 58 percent with Asacol (n=2,384), 49 percent with Pentasa (250mg) (n=122) and 59 percent with Pentasa (500mg) (n=542), 59 percent with balsalazide (n=445), and 56 percent with Dipentum (500 mg) (n=36).

Persistent (continuing) patients were defined as those who refilled their prescription within a period of up to twice the duration of the prescription that preceded the refil
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SOURCE Shire plc
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