Navigation Links
Shire Enhances its Orphan Drug Pipeline With the Acquisition of a New Clinical Candidate for Metachromatic Leukodystrophy
Date:4/23/2008

BASINGSTOKE, England and CAMBRIDGE, Massachusetts, April 24 /PRNewswire-FirstCall/ -- Shire plc (LSE: SHP, NASDAQ: SHPGY), the global specialty biopharmaceutical company, announces the acquisition of arylsulfatase -A (ASA) an Enzyme Replacement Therapy (ERT) in Phase 1-2 clinical trials for Metachromatic Leukodystrophy (MLD) from the Danish company Zymenex A/S (Zymenex).

MLD is a serious, life-limiting disease in which patients experience progressive irreversible neurological damage. MLD is caused by a deficiency in the enzyme ASA which causes an excess concentration of sulphatide in cells and an ensuing breakdown of myelin. There are approximately 2,000 MLD patients in developed world markets(1).

The newly acquired ASA product, currently known as METAZYM(TM), has completed a Phase Ib clinical trial in 12 MLD patients in Europe and an extension to this study is ongoing. The product has received Food and Drug Administration (FDA) approval for its Investigational New Drug (IND) application to initiate a phase 2 clinical trial and has been granted Orphan Drug Designation in the United States and in the European Union.

Sylvie Gregoire, President of Shire's Human Genetic Therapies business, commented:

"This product fits very well with Shire's ERT portfolio of treatments for Lysosomal Storage Disorders (LSD). Shire HGT has been committed to MLD and by acquiring this mid-stage clinical program we hope to bring a MLD treatment to patients two years earlier than anticipated."

Shire is making a payment to Zymenex of US$135 million for the acquisition of global rights to the product upon completion of the transaction, which is conditional upon the receipt of customary consents. Zymenex is also providing certain transition services, including know-how transfer, for up to six months after completion. The transaction includes no royalties or other downstream payment obligations.

(1) Scriver et al 1995

Notes to editors

'/>"/>
SOURCE Shire PLC
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Shire Strives to Increase Adherence Among Chronic Kidney Disease Stage 5 Patients
2. Pharmion and MethylGene Announce U.S. Orphan Drug Designation Granted for MGCD0103 for the Treatment of Hodgkins Lymphoma
3. Advanced Life Sciences Announces ALS-357 Granted FDA Orphan Drug Designation for Metastatic Melanoma
4. US FDA Grants Orphan Drug Status to Immtechs Pafuramidine for Treatment of African Sleeping Sickness
5. Knopp Neurosciences Receives Orphan Designation for KNS-760704 for Treatment of ALS
6. Voices to Unite in Los Angeles for 6,000 Children Orphaned Daily
7. Celldex Therapeutics Announces Orphan Drug Designation for CDX-110, a Novel EGFRvIII Vaccine for Glioblastoma Multiforme
8. Insmed Receives FDA Orphan Drug Designation for IPLEX(TM) in the Treatment of Myotonic Muscular Dystrophy
9. Antheras A-001 Receives Orphan Drug Status for the Prevention of Acute Chest Syndrome in Patients With Sickle Cell Disease
10. Jazz Pharmaceuticals, Inc. Announces Receipt of FDA Orphan Drug Designation for Recurrent Acute Repetitive Seizures Product Candidate
11. Fovea Pharmaceuticals Receives Orphan Drug Designation from EC for RdCVF for the Treatment of Retinitis Pigmentosa
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... Jan. 22, 2015  Profil Institute for Clinical Research, Inc., ... obesity, announced today a new textbook,  Translational Research Methods ... Springer, a leading global scientific publisher. The ... techniques for use in early phase clinical studies of ...
(Date:1/22/2015)... , Jan. 22, 2015 Research and Markets ... "Infectious Disease Diagnostics Market by Product, Application, Technology, ... to their offering. , The infectious disease ... 7.9% to reach $18,156.2 million by 2019 from $12,422.8 ...
(Date:1/22/2015)... DUBLIN , Jan. 22, 2015 Research and Markets ... "Allergy Diagnostics Market by Allergen Source, Product & by ... their offering. The global allergy diagnostics market ... to grow at a CAGR of 12.67%, to reach $2,230.72 ...
Breaking Medicine Technology:New Textbook "Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug Development" Provides Critical Review Of Current And Emerging Clinical Investigation Methods 2New Textbook "Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug Development" Provides Critical Review Of Current And Emerging Clinical Investigation Methods 3Global Infectious Disease Diagnostics (Instruments, Reagents, Services, Software) Market - Forecast to 2019 2Global Infectious Disease Diagnostics (Instruments, Reagents, Services, Software) Market - Forecast to 2019 3Global Allergy Diagnostics (Immunoassay Analyzer, Luminometer, Assay Kit, Consumables) Market - Forecast to 2019 2Global Allergy Diagnostics (Immunoassay Analyzer, Luminometer, Assay Kit, Consumables) Market - Forecast to 2019 3
... ATLANTA, Oct. 3, 2011 As 73% of all ... 300 beds or less, collectively these hospitals account for ... well-located access to emergency and medical care, the role ... Americans. To sustain community healthcare with quality physicians and ...
... Optimer Pharmaceuticals, Inc. (NASDAQ: OPTR ) today ... Newsmakers in the Biotech Industry conference on Friday, October 21 ... ) A live audio webcast of ... the Company,s website at www.optimerpharma.com .  Replays of the ...
Cached Medicine Technology:Craneware Supports Forward-Thinking Community Hospital Executives to Strengthen U.S. Community Healthcare's Business Performance 2Craneware Supports Forward-Thinking Community Hospital Executives to Strengthen U.S. Community Healthcare's Business Performance 3
(Date:1/22/2015)... 23, 2015 Recently, Weddingshe.com has added many ... has announced its highest annual revenues in the past three ... popular glamorous wedding dresses. , According to the sales manager ... dress promotions for them in 2015. This point can be ...
(Date:1/22/2015)... Payday lending practices in four southern ... financial distress to the states that permit them, according ... Center on Race and Wealth. , While they generate ... loans at the same time substantially depress economic activity, ...
(Date:1/22/2015)... January 22, 2015 JJsHouse.com is a famous ... Today, the business announces its latest collection of wedding ... “The most important issue is the wedding dress on your ... in a woman’s life. Every bride wants to find the ...
(Date:1/22/2015)... Richmond, VA (PRWEB) January 22, 2015 ... the power at the Science Museum of Virginia. Wicked ... 24. , Wicked Plants unearths 75 poisonous, carnivorous and ... traverse through each room to uncover the biochemical, physical ...
(Date:12/26/2014)... 26, 2014 It is said that nothing ... Today, UWDress.com, the famous wedding dress supplier, shows its ... site-wide cocktail gown promotion. , UWDress.com’s navy cocktail gowns ... they come in high fashion styles. Simple dresses in bright ...
Breaking Medicine News(10 mins):Health News:Weddingshe Announces A Special Offer On Its Popular Glamorous Wedding Dresses 2Health News:Howard University Spotlights the Economic Impact of Payday Lending in Southern States 2Health News:Find The Most Suitable Wedding Dress At JJsHouse.com 2Health News:Wicked Plants are taking over the Science Museum of Virginia 2Health News:UWDress.com Shows Its New Navy Cocktail Dresses For 2015 2
... HealthDay Reporter , TUESDAY, Dec. 7 (HealthDay News) ... more likely to take up smoking than teens whose parents ... research. , In fact, the study authors estimated that ... movies, their risk of starting to smoke could drop two ...
... News) -- Teens who have health problems have fewer friends ... than they actually are, new research shows. U.S. researchers ... a 1994-1996 survey that asked them about their health and ... health as "excellent" or "very good." The rest of the ...
... ER? A group of computer engineers at Vanderbilt ... available to create robot assistants that can perform effectively ... specialists in emergency medicine at Vanderbilt University Medical Center ... groups have formed an interdisciplinary team to explore the ...
... The John Theurer Cancer Center at Hackensack University Medical ... annual meeting of the American Society of Hematology (ASH) ... ASH meeting is the world,s leading scientific gathering of ... the 40 abstracts from the John Theurer Cancer Center ...
... School of Hygiene & Tropical Medicine (LSHTM) has contributed to ... the occurrence of several common cancers. The study is published ... started and carried out by Professor Peter Rothwell in Oxford, ... of aspirin. These have been primarily concerned with reducing heart ...
... A study published in the December issue of The ... tomography/computed tomography (PET/CT) scans as a potentially useful tool ... with radiofrequency ablation (RFA). RFA, which uses localized thermal ... an alternative treatment for patients unable to undergo surgery ...
Cached Medicine News:Health News:Watching R-rated Movies Ups Odds of Teens Smoking 2Health News:Watching R-rated Movies Ups Odds of Teens Smoking 3Health News:Teens' Poor Health Linked to Fewer Friends 2Health News:Developing robots for the hospital emergency room 2Health News:Developing robots for the hospital emergency room 3Health News:John Theurer Cancer Center presents studies on promising therapies for aggressive blood cancers 2Health News:John Theurer Cancer Center presents studies on promising therapies for aggressive blood cancers 3Health News:John Theurer Cancer Center presents studies on promising therapies for aggressive blood cancers 4Health News:John Theurer Cancer Center presents studies on promising therapies for aggressive blood cancers 5Health News:John Theurer Cancer Center presents studies on promising therapies for aggressive blood cancers 6Health News:John Theurer Cancer Center presents studies on promising therapies for aggressive blood cancers 7Health News:Low-dose aspirin reduces death rates from range of cancers by between 20 and 30 percent 2Health News:Fewer guessing games for lung cancer patients 2
All Day Comfort for the Lower Body...
Designed for special procedures, this Wrap-Around apron has .50mm Pb in the front and .25mm Pb in the back. The velcro fasteners are adjustable to provide the most comfortable fit....
Setting a new standard in protective apparel. The unique, patented Cool-Tech™ mesh-back design fits the natural contour of the body while reducing the amount of weight carried on the shoulders ...
Protect your thyroid with a personal Thyroid Shield. While other shields have a rough, abrasive bias binding edging the neck, these have a softer, smoother turned seam that helps protect your neck fr...
Medicine Products: