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Shire Delivers Strong First Quarter Performance and Reiterates its Expectation of Good Full Year Earnings Growth
Date:4/26/2012

All trademarks designated ® and ™ used in this press release are trademarks of Shire plc or companies within the Shire group except for 3TC® and ZEFFIX® which are trademarks of GSK, PENTASA® which is a registered trademark of FERRING B.V., FABRAZYME® and CEREZYME® which are trademarks of Genzyme Corporation, CONCERTA® which is a trademark of ALZA Corporation and DAYTRANA® which is a trade mark of Noven Pharmaceuticals Inc. Certain trademarks of Shire plc or companies within the Shire group are set out in Shire's Annual Report on Form 10-K for the year ended December 31, 2011.

For further information please contact:

Investor Relations        
  - Eric Rojas    erojas@shire.com    +1-781-482-0999
  - Sarah Elton-Farr    seltonfarr@shire.com     +44-1256-894-157
Media        
  - Jessica Mann (Corporate)    jmann@shire.com    +44-1256-894-280
  - Gwen Fisher (Specialty Pharma)    gfisher@shire.com     +1-484-595-9836
  - Jessica Cotrone (Human Genetic Therapies)    jcotrone@shire.com    +1-781-482-9538
  - Lindsey Hart (Regenerative Medicine)    lhart@abh.com    +1-615-250-3311


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4. Shires Investigational Nonstimulant ADHD Treatment INTUNIV(TM) (Guanfacine Extended Release) Demonstrated Significant Efficacy in Reducing ADHD Symptoms at All Measured Time Points Up to 24 Hours Postdose
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6. Shire to add New Orphan Drug to its HGT Portfolio - EU Launch Imminent
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10. Shire has Filed a Treatment Protocol for Velaglucerase Alfa for Gaucher Disease
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