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Shire Delivers Strong First Quarter Performance and Reiterates its Expectation of Good Full Year Earnings Growth
Date:4/26/2012

epreciation and amortization 73.0 63.5 Share based compensation 22.0 15.7 Other (5.9) (5.5) Movement in deferred taxes (20.8) 42.2 Equity in earnings of equity method investees (0.9) (1.2) Changes in operating assets and liabilities: Increase in accounts receivable (65.2) (74.8) Increase in sales deduction accrual 54.5 31.2 Increase in inventory (25.0) (12.7) Decrease in prepayments and other assets 17.2 5.0 Decrease in accounts and notes payable and other liabilities (30.3) (72.8) Net cash provided by operating activities[(A)] 257.0 201.9

CASH FLOWS FROM INVESTING ACTIVITIES: Movements in restricted cash 5.7 (4.1) Purchases of non-current investments (4.1) (2.5) Purchases of PP&E (31.7) (46.5) Purchases of intangible assets (22.0) - Proceeds received on sale of product rights 5.6 - Proceeds from capital expenditure grants 8.4 - Proceeds from disposal of non-current investments and PP&E 3.8 0.1 Returns from equity investments 0.1 1.1 Net cash used in investing activities[(B)] (34.2) (51.9)

CASH FLOWS FROM FINANCING ACTIVITIES: Payment under building financing obligation (0.3) (0.2) Proceeds from exercise of options 0.9 0.2 Excess tax benefit associated with exercise of stock options 34.8 9.0 Net cash provided by financing activities[(C)] 35.4 9.0 Effect of foreign exchange rate changes on cash and cash equivalents[(D)] 1.2 2.4 Net increase in cash and cash equivalents[(A) +(B) +(C) +(D)] 259.4 161.4 Cash and cash equivalents at beginning of period 620.0 550.6 Cash and cash equivalents at end of period 879.4 712.0

Unaudited US GAAP results for the three months to March 31, 2012

Selected Notes to the Financial Statements

(1)  Earnings Per Share ("EPS")

3 months to March 31, 2012 2011 $M $M Net Income 238.4 211.3 Numerator for basic EPS 238.4 211.3 Interest on convertible bonds, net of tax 8.4 8.4 Numerator for diluted EPS 246.8 219.7 Weighted average number of shares
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