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Shire Delivers Strong First Quarter Performance and Reiterates its Expectation of Good Full Year Earnings Growth
Date:4/26/2012

audited US GAAP results for the three months to March 31, 2012
Consolidated Statements of Income

3 months to March 31, 2012 2011 $M $M Revenues: Product sales 1,106.9 889.3 Royalties 56.3 73.6 Other revenues 8.6 9.3 Total revenues 1,171.8 972.2 Costs and expenses: Cost of product sales[(1)] 158.4 124.5 Research and development 220.3 177.9 Selling, general and administrative[(1)] 500.0 402.9 (Gain)/loss on sale of product rights (7.2) 1.3 Reorganization costs - 5.5 Integration and acquisition costs 5.3 (6.4) Total operating expenses 876.8 705.7 Operating income 295.0 266.5 Interest income 0.8 0.6 Interest expense (10.2) (9.2) Other income, net 1.9 0.3 Total other expense, net (7.5) (8.3) Income from continuing operations before income taxes and equity in earnings of equity method investees 287.5 258.2 Income taxes (50.0) (48.1) Equity in earnings of equity method investees, net of taxes 0.9 1.2 Net income 238.4 211.3

Earnings per ordinary share - basic 43.1c 38.5c Earnings per ADS - basic 129.3c 115.5c Earnings per ordinary share - diluted 41.4c 37.0c Earnings per ADS - diluted 124.2c 111.0c Weighted average number of shares: Millions Millions Basic 553.5 549.5 Diluted 595.6 593.6

[(1)] Cost of product sales includes amortization of intangible assets relating to favorable manufacturing contracts of $0.2 million for the three months to March 31, 2012 (2011: $0.4 million). SG&A costs include amortization of intangible assets relating to intellectual property rights acquired of $45.6 million for the three months to March 31, 2012 (2011: $36.1 million).

Unaudited US GAAP results for the three months to March 31, 2012
Consolidated Statements of Cash Flows

3 months to March 31, 2012 2011 $M $M CASH FLOWS FROM OPERATING ACTIVITIES: Net income 238.4 211.3 Adjustments to reconcile net income to net cash provided by operating activities: D
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