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Shire Delivers Strong First Quarter Performance and Reiterates its Expectation of Good Full Year Earnings Growth
Date:4/26/2012

primarily driven by significant growth in US prescription demand, due to an increase in INTUNIV's market share and growth in the US ADHD market, together with the effect of price increases taken since Q1 2011. These positive factors were partially offset by higher sales deductions as a percentage of gross product sales in Q1 2012 compared to Q1 2011.

PENTASA - Ulcerative colitis

Product sales of PENTASA continued to grow as the impact of price increases taken since Q1 2011 offset lower US prescription demand.

DERMAGRAFT - Diabetic Foot Ulcers ("DFU")

DERMAGRAFT continues to see good revenue growth in the US, up 10% compared to Q1 2011 (as reported by ABH[(1)]). The growth resulted from a combination of price increases taken since Q1 2011, market growth and an increase in DERMAGRAFT's share of the market.

[(1)]Shire acquired DERMAGRAFT through its acquisition of ABH in Q2 2011.

FOSRENOL - Hyperphosphatemia

FOSRENOL product sales increased by 10% primarily due to modest stocking in Q1 2012 and the impact of price increases taken since Q1 2011 which partially offset lower US prescription demand. Product sales of FOSRENOL outside of the US remained constant compared with Q1 2011.

FIRAZYR - Hereditary Angioedema

FIRAZYR sales growth was driven primarily by the impact of the US launch in Q4 2011, where we continue to see both good growth in new patients starting treatment and promising levels of repeat usage by existing patients. The more established markets in Europe also continue to grow following the approval of self administration in Q1 2011.

2.    Royalties

Year on year growth Royalties to Product Shire $M Royalties CER ADDERALL XR 25.3 51% 51% 3TC(R) and ZEFFIX(R) 13.6 -62% -62% FOSRENOL 10.0 23% 22% Other 7.4 -44% -43% Total 56.3 -24% -23%


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SOURCE Shire plc
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3. Shire to Present Additional Scientific Data on ADHD Treatment Portfolio at American Psychiatric Association Annual Meeting
4. Shires Investigational Nonstimulant ADHD Treatment INTUNIV(TM) (Guanfacine Extended Release) Demonstrated Significant Efficacy in Reducing ADHD Symptoms at All Measured Time Points Up to 24 Hours Postdose
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9. Shire Presented Results of a New Database Analysis on Lialda(R) (Mesalamine) and Other 5-ASAs for Ulcerative Colitis at Digestive Disease Week
10. Shire has Filed a Treatment Protocol for Velaglucerase Alfa for Gaucher Disease
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