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Shire Delivers Strong First Quarter Performance and Reiterates its Expectation of Good Full Year Earnings Growth
Date:4/26/2012

tions 18 Safe Harbor Statement 20 Explanation of Non GAAP Measures 21 Trademarks 21

Dial in details for the live conference call  for investors 14:00 BST/9:00 EDT on April 26, 2012:

UK dial in:            0800 077 8492 or 0844 335 0351

US dial in:            1 866 8048688 or 1 718 3541175

International dial in:        +44 844 335 0351

Password/Conf ID:        338270

Live Webcast:            http://www.shire.com/shireplc/en/investors

OVERVIEW OF FIRST QUARTER 2012 FINANCIAL RESULTS

1.    Product sales

For the three months to March 31, 2012 product sales increased by 24% to $1,106.9 million (Q1 2011: $889.3 million) and represented 94% of total revenues (Q1 2011: 91%).

US Exit Market Product Highlights Year on year growth Share[(1)] Product Sales $M Sales CER US Rx[(1)] VYVANSE 260.0 +29% +29% +23% 17% REPLAGAL 134.4 +28% +31% n/a[(3)] n/a[(3)] ELAPRASE 125.6 +21% +24% n/a[(2)] n/a[(2)] ADDERALL XR 111.4 +0% +0% +4% 7% LIALDA/MEZAVANT(R) 90.0 +3% +4% +3% 21% VPRIV 71.7 +22% +23% n/a[(2)] n/a[(2)] INTUNIV 68.5 +63% +63% +54% 4% PENTASA(R) 65.8 +2% +2% -6% 14% DERMAGRAFT 48.8 n/a n/a n/a[(2)] n/a[(2)] FOSRENOL 45.5 +10% +12% -23% 5% FIRAZYR 19.7 +272% +280% n/a[(2)] n/a[(2)] OTHER 65.5 -4% -2% n/a n/a Total product sales 1,106.9 +24% +26%

[(1)]    Data provided by IMS Health National Prescription Audit ("IMS NPA"). Exit market share represents the average monthly US market share in the month ended March 31, 2012.

[(2)]    IMS NPA Data not available.

[(3)]    Not sold in the US in Q1 2012.

VYVANSE - ADHD

VYVANSE product sales grew strongly in Q1
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