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Shire Delivers Strong 2012 Results and Reiterates Confidence in 2013
Date:2/14/2013

al HGT product sales 369.4 329.1 12% 31% Regenerative Medicine DERMAGRAFT 18.9 53.3 -65% 1% Total RM product sales 18.9 53.3 -65% 1% Total product sales 1,097.6 1,049.2 5% 91% Royalties: 3TC and ZEFFIX 56.8 18.6 205% 5% ADDERALL XR 8.1 40.5 -80% 1% FOSRENOL 16.3 15.1 8% 1% Other 6.0 9.5 -37% <1% Total royalties 87.2 83.7 4% 7% Other revenues 16.4 9.3 76% 2% Total revenues 1,201.2 1,142.2 5% 100%

Unaudited results for the year to December 31, 2012

Non GAAP reconciliation

Year to December 31, 2012 US GAAP Adjustments Non GAAP (a) (b) (c) (d) (e) $M $M $M $M $M $M $M Total revenues 4,681.2 - - - - - 4,681.2 Costs and expenses: Cost of product sales 645.4 - - - - (31.5) 613.9 R&D 965.5 (71.2) (23.0) - - (22.5) 848.8 SG&A 2,114.0 (320.8) - - (102.6) (59.8) 1,630.8 Gain on sale of product rights (18.1) - - 18.1 - - - Integration and acquisition costs 25.2 - (25.2) - - - - Depreciation - - - - - 113.8 113.8 Total operating expenses 3,732.0 (392.0) (48.2) 18.1 (102.6) - 3,207.3 Operating income 949.2 392.0 48.2 (18.1) 102.6 - 1,473.9 Interest income 3.1 - - - - - 3.1 Interest expense (38.2) - - - - - (38.2) Other (expense)/income, net (2.7) 4.0 - - - - 1.3 Total other expense, net (37.8) 4.0 - - - - (33.8) Income before income taxes and equity in earnings of equity method investees 911.4 396.0 48.2 (18.1) 102.6 - 1,440.1 Income taxes (167.0) (59.5) (9.9) - (28.3) - (264.7) Equity in earnings of equity method investees, net of tax 1.0 - - - - - 1.0 Net income 745.4 336.5 38.3 (18.1) 74.3 - 1,176.4 Impact of convertible debt, net of tax 31.3 - - - - - 31.3 Numerator for diluted EPS 776.7 336.5 38.3 (18.1) 74.3 - 1,207.7 Weighted average number of shares (millions) - diluted 593.5 - - - - - 593.5 Diluted earnings per ADS 392.7c 170.0c 19.4c (9.1c) 37.5c - 610.5c The following items are included in Adjustments: (a) Amortization and asset impairments: Impairment of IPR&D intangible assets for RESOLOR in the EU ($71.2
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SOURCE Shire plc
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