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Shire Delivers Strong 2012 Results and Reiterates Confidence in 2013
Date:2/14/2013

31, 2012 2011 2012 2012 % % of total $M $M change revenue Net product sales: Specialty Pharmaceuticals Behavioral Health VYVANSE 1,029.8 805.0 28% 22% ADDERALL XR 429.0 532.8 -19% 9% INTUNIV 287.8 223.0 29% 6% EQUASYM(R) 29.2 19.9 47% 1% 1,775.8 1,580.7 12% 38% Gastro Intestinal LIALDA/MEZAVANT 399.9 372.1 7% 9% PENTASA 265.8 251.4 6% 6% RESOLOR 11.8 6.1 93% <1% 677.5 629.6 8% 15% General products FOSRENOL 172.0 166.9 3% 4% XAGRID(R) 97.2 90.6 7% 2% 269.2 257.5 5% 6% Other product sales 112.4 147.8 -24% 2% Total SP product sales 2,834.9 2,615.6 8% 61% Human Genetic Therapies ELAPRASE 497.6 464.9 7% 11% REPLAGAL 497.5 475.2 5% 11% VPRIV 306.6 256.2 20% 6% FIRAZYR 116.3 33.0 252% 2% Total HGT product sales 1,418.0 1,229.3 15% 30% Regenerative Medicine DERMAGRAFT 153.8 105.3 46% 3% Total RM product sales 153.8 105.3 46% 3% Total product sales 4,406.7 3,950.2 12% 94% Royalties: 3TC and ZEFFIX 91.6 82.7 11% 2% ADDERALL XR 70.3 107.1 -34% 2% FOSRENOL 53.3 46.5 15% 1% Other 26.4 47.2 -44% <1% Total royalties 241.6 283.5 -15% 5% Other revenues 32.9 29.7 11% 1% Total revenues 4,681.2 4,263.4 10% 100%

Unaudited US GAAP results for the three months to December 31, 2012

Selected Notes to the Financial Statements

(2)  Analysis of revenues

3 months to December 31, 2012 2011 2012 2012 % % of total $M $M change revenue Net product sales: Specialty Pharmaceuticals Behavioral Health VYVANSE 256.5 217.1 18% 21% ADDERALL XR 81.5 124.8 -35% 7% INTUNIV 81.2 65.4 24% 7% EQUASYM 7.9 4.3 84% 1% 427.1 411.6 4% 36% Gastro Intestinal LIALDA/MEZAVANT 111.4 96.1 16% 9% PENTASA 69.1 65.2 6% 6% RESOLOR 3.5 2.1 67% <1% 184.0 163.4 13% 15% General products FOSRENOL 45.2 39.9 13% 4% XAGRID 26.5 21.4 24% 2% 71.7 61.3 17% 6% Other product sales 26.5 30.5 -13% 2% Total SP product sales 709.3 666.8 6% 59% Human Genetic Therapies ELAPRASE 139.3 124.0 12% 12% REPLAGAL 118.2 120.9 -2% 10% VPRIV 77.3 69.3 12% 6% FIRAZYR 34.6 14.9 132% 3% Tot
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SOURCE Shire plc
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