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Shire Delivers Strong 2012 Results and Reiterates Confidence in 2013
Date:2/14/2013

TASA 265.8 +6% +6% -5% 14% FOSRENOL(R) 172.0 +3% +6% -19% 4% DERMAGRAFT(4) 153.8 +46% +46% n/a(2) n/a(2) FIRAZYR 116.3 +252% +258% n/a(2) n/a(2) OTHER 250.6 -5% -2% n/a n/a Excluding ADDERALL XR 3,977.7 +16% +18% ADDERALL XR 429.0 -19% -19% -11% 5% Total 4,406.7 +12% +13% (1) Data provided by IMS Health National Prescription Audit ("IMS NPA"). Exit market share represents the average US market share in the month ended December 31, 2012. (2) IMS NPA Data not available. (3) Not sold in the US in 2012. (4) DERMAGRAFT was acquired by Shire on June 28, 2011 (sales growth above reflects full year 2012 sales compared to post acquisition sales for 2011).

VYVANSE - ADHD

VYVANSE product sales grew strongly (28%) in 2012 as a result of higher prescription demand, due to growth in US ADHD market (+9%) and VYVANSE's share of that market, and as a result of a price increase taken in 2012. These positive factors, together with lower sales deductions in 2012, more than offset the effect of higher retailer destocking in 2012 compared to 2011 and some shipment slippage at the end of the fourth quarter.

ELAPRASE - Hunter syndrome

Reported ELAPRASE sales growth (7%) was driven by an increase in the number of patients on therapy. On a CER basis, ELAPRASE sales grew by 11% as reported sales were held back by unfavorable foreign exchange (amounting to approximately $20 million) primarily due to weaker European currencies in 2012 compared to 2011. The increase in ELAPRASE sales between Q3 and Q4 of 2012 was partly driven by the timing of certain large orders from markets which order less frequently.

REPLAGAL - Fabry disease

Reported REPLAGAL sales growth (5%) was driven by an increase in the number of patients on therapy. On a CER basis, REPLAGAL sales grew by 10%, as reported sales were impacted by unfavorable foreign exchange (amounting to approximately $26 million), primarily due to weaker European currencies in 2012 compared to 2
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SOURCE Shire plc
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