Shire Continues to Deliver Excellent Growth From Cor...(17) and on a US GAAP basis diluted earni...),Health

Date:10/30/2009

17), and on a US GAAP basis diluted earnings per ADS were $0.33 (Q3 2008: $(0.20)). - During the first three quarters of 2009 Shire has generated Non GAAP diluted earnings per ADS of $2.38 ($1.74 on a US GAAP basis). THIRD QUARTER HIGHLIGHTS AND RECENT DEVELOPMENTS Products VYVANSE - for the treatment of Attention Deficit and Hyperactivity Disorder ("ADHD") - Following a review of governing statutory and regulatory standards and public comments, the US Food and Drug Administration ("FDA") has affirmed its prior decision to grant five-year New Chemical Entity ("NCE") exclusivity to lisdexamfetamine dimesylate. The five-year exclusivity period for VYVANSE expires on February 23, 2012. As a consequence of this decision, the FDA appropriately refused to file the Abbreviated New Drug Application submitted by Actavis Elizabeth, LLC ("Actavis") for generic lisdexamfetamine dimesylate in January 2009. VYVANSE is covered by US patents which remain in effect until June 29, 2023. INTUNIV(TM) - for the treatment of ADHD in children and adolescents in the US - On September 3, 2009 Shire announced that it received approval from the FDA for INTUNIV Extended Release Tablets for the treatment of ADHD in children and adolescents aged 6 to 17 years. INTUNIV, a once-daily non-scheduled formulation of guanfacine, is the first selective alpha-2A adrenergic receptor agonist approved for the treatment of ADHD. - Once-daily INTUNIV is expected to be widely available in US pharmacies in November 2009 and will come in four dosage strengths (1 mg, 2 mg, 3 mg, and 4 mg). INTUNIV will be marketed in the US by the existing Shire ADHD sales team of nearly 600 representatives. FOSRENOL(R) - for the treatment of pre-dialysis chronic kidney disease ("CKD") in the EU - Shire has received approval through the European Mutual Rec
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