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Shire Continues to Deliver Excellent Growth From Core Products

91% of total revenues (2008: 92%). Excluding ADDERALL XR, product sales from core products increased by 20% to $531.6 million (2008: $443.8 million).

    Product Highlights

                                                     CER     US Rx  Quarterly
                                         Sales  Growth(2) Growth(1)   Market
    Product                 Sales $M  Growth(2)       (3)       (2)  Share(1)
    VYVANSE                    129.0       34%       34%       57%       13%
    DAYTRANA                    17.4       -4%       -4%      -12%        1%
    EQUASYM                      9.2       n/a       n/a    n/a(5)    n/a(5)
    LIALDA / MEZAVANT           65.4       62%       63%       34%       17%
    PENTASA                     51.3        4%        4%       -3%       16%
    FOSRENOL                    47.7       11%       14%       -3%        8%
    XAGRID(R)                   21.5       11%       18%    n/a(5)    n/a(5)

    ADDERALL XR                 70.9      -74%      -74%      -59%        8%

    Human Genetic Therapies
    ELAPRASE                    90.9       16%       20%    n/a(4)    n/a(4)
    REPLAGAL                    48.3        8%       15%    n/a(5)    n/a(5)
    FIRAZYR                      1.8         -         -    n/a(5)    n/a(5)

    (1) Product specific prescription data is provided by IMS Health ("IMS")
        National Prescription Audit, a leading global provider of business
        intelligence for the pharmaceutical and healthcare industries. All
        other US market share data stated in the text below is also provided
        by IMS.
    (2) Compared to Q3 2008.
    (3) CER growth, which is a Non GAAP measure, is calculated after
        restating Q3 2009 results using Q3 2008 average foreign exchange
    (4) I
SOURCE Shire Plc
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