Navigation Links
Shionogi-ViiV Healthcare announces positive initial data from phase III study of dolutegravir-based regimen vs Atripla in HIV
Date:7/10/2012

LONDON, July 11, 2012 /PRNewswire/ -- Shionogi-ViiV Healthcare LLC today announced that initial results have been received from the Phase III SINGLE (ING114467) study of the investigational integrase inhibitor dolutegravir in treatment-naive adults with HIV-1. The study demonstrated superiority of the dolutegravir-based regimen compared to the single tablet regimen Atripla®.  At 48 weeks, 88% of study participants on the dolutegravir regimen were virologically suppressed (<50 copies/mL) vs. 81% of participants on the single tablet regimen Atripla [difference and 95% CI; 7.4% (+2.5% to +12.3%); difference in the primary endpoint was statistically significant, p=0.003]. Differences in efficacy were primarily driven by a higher rate of discontinuation due to adverse events on the Atripla arm. The SINGLE study was designed to demonstrate non-inferiority of the dolutegravir-based regimen versus Atripla, and the primary analysis met this criterion.  Statistical superiority was concluded as part of a subsequent, pre-specified testing procedure.

SINGLE is an ongoing double blind, double dummy study designed to compare the efficacy and safety of two antiretroviral regimens: dolutegravir 50mg plus abacavir/lamivudine (Kivexa®/Epzicom®) versus Atripla® (tenofovir/emtricitabine/efavirenz). The primary endpoint was the proportion of study participants with undetectable HIV-1 RNA (<50c/mL) at 48 weeks; 414 treatment-naive study participants were randomised and exposed to the dolutegravir-based  regimen and 419 to the Atripla arm.  Overall, 2% of subjects on the dolutegravir-based regimen discontinued due to adverse events vs. 10% of those receiving the Atripla regimen. The most common drug related adverse events on Atripla were in the nervous system System Organ Class (reported by 41% of Atripla recipients, vs. 15% of participants receiving the dolutegravir-based regimen), while the most common drug relat
'/>"/>

SOURCE Shionogi-ViiV Healthcare LLC
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related medicine technology :

1. Clinical Trial at Evergreen Healthcare Shows Intestinal Gel Reduces Symptoms of Advanced Parkinsons Disease
2. Netsmarts Focus on Innovation to Help Health and Human Service Providers Span the Spectrum of Care in the Healthcare 3.0 Environment
3. Qmed, the Leading Global MedTech Industry Resource, Partners with Clarimed, to Provide the Medical Manufacturing and Healthcare Industry with FDA Reports on Adverse Events
4. Attendees Save Up To $800 on Global Healthcare Conferences in 2012 by Registering Through Global Information Inc.
5. Auxilium Pharmaceuticals to Present at the Deutsche Bank 37th Annual Healthcare Conference
6. Nearly 300 Medical Device, Healthcare Professionals Attend First National Conference on Value-driven Engineering
7. Varian Medical Systems and Siemens Healthcare Announce Global Collaboration to Advance Clinical Capabilities and Offerings in Radiotherapy and Radiosurgery
8. Med Ad News Honors Healthcare Communication Agencies at 23rd Annual Manny Awards
9. Quest Diagnostics Establishes Unique Healthcare Identifier to Improve Access to Vital Patient Health Information; 80 Million Patient IDs Created to Date
10. Evergreen Healthcare Foundation Gala Raises Nearly $1.1 Million to Benefit Breast Health Center
11. Bayer Employees Named Rising Stars by Healthcare Businesswomens Association
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... Aug. 20, 2014 Reportlinker.com announces ... available in its catalogue: Personal ... Trends and Opportunities to 2018 ... The report provides in depth market analysis, ... accident and health insurance segment, including: - ...
(Date:8/20/2014)... 2014 Reportbuyer.com has added a new market ... https://www.reportbuyer.com/product/98394/Global-Cardiac-Defibrillators-Industry.html This report analyzes ... by the following Product Segments: Implantable/Internal Cardiac Defibrillators, and ... the US, Canada , ... Asia-Pacific , Middle East ...
(Date:8/20/2014)... RANCHO MIRAGE, Calif. , Aug. 20, 2014 ... patient named Fernando Davila has been successfully treated ... eating disease", by Dr, Anibal R. Gauto , Medical ... Care Center, at Eisenhower Medical Center in Rancho ... a new treatment pioneered by Dr. John Crew ...
Breaking Medicine Technology:Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 2Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 3Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 4Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 5Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 6Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 7Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 8Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 9Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 10Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 11Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 12Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 13Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 14Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 15Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 16Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 17Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 18Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 19Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 20Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 21Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 22Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 23Global Cardiac Defibrillators Industry 2Global Cardiac Defibrillators Industry 3Global Cardiac Defibrillators Industry 4Global Cardiac Defibrillators Industry 5Global Cardiac Defibrillators Industry 6Global Cardiac Defibrillators Industry 7Global Cardiac Defibrillators Industry 8Global Cardiac Defibrillators Industry 9Global Cardiac Defibrillators Industry 10Global Cardiac Defibrillators Industry 11Global Cardiac Defibrillators Industry 12Global Cardiac Defibrillators Industry 13Global Cardiac Defibrillators Industry 14
... Calif., Sept. 12 Bionovo, Inc.,(Nasdaq: BNVI ... in the journal for,the American Society for Pharmacology ... In Vitro Metabolism of,Liquiritigenin, a Bioactive Compound Isolated ... Liquiritigenin is one of the active compounds ...
... a new study, men with,locally recurrent prostate cancer ... treatment option., A Phase III clinical trial ... is investigating the safety and efficacy of High ... recurrent prostate,cancer following failed external beam radiation therapy ...
Cached Medicine Technology:Bionovo Reports on Metabolic Studies Related to Its Menopausal Hot Flash Drug Candidate 2Bionovo Reports on Metabolic Studies Related to Its Menopausal Hot Flash Drug Candidate 3High Intensity Focused Ultrasound for Locally Recurrent Prostate Cancer Following External Beam Radiation Therapy Investigated in Phase III Clinical Study 2
(Date:8/21/2014)... mynt welcomes industry leaders Rob and Tiffanie ... growing company. Since its pre-launch in April, mynt has ... continues to gain momentum leading up to its official ... came into network marketing by chance. Tiffanie worked for ... marketing companies. Tiffanie needed help at one particular distributor ...
(Date:8/21/2014)... August 21, 2014 According to ... Application (Biodegradable polymer, Food & Beverage, Personal care ... (Packaging, Agriculture, Automobile, Electronics, Textile) & Geography - ... lactic acid and polylactic acid markets and segments ... each market, based on their sub-segments, in terms ...
(Date:8/21/2014)... Luis Obispo, CA (PRWEB) August 21, 2014 ... edition of Current Pedorthics, a bi-monthly publication of the Pedorthic ... field of pedorthics. , Bunion Bootie ... an alternative solution for bunion sufferers and their pain. It ... worn in nearly any shoe to eliminate the friction and ...
(Date:8/21/2014)... (PRWEB) August 21, 2014 While golfing ... found it hard to stay focused on his game ... mosquitoes. The constant whine, slapping and continual need to ... innovative methods to stay protected from insects while golfing. ... career in the Financial Services/Investment Banking Industry, decided to ...
(Date:8/21/2014)... (PRWEB) August 21, 2014 Atlantic Information ... of ACO Business News and The AIS Report on ... the Blue Cross Blue Shield Association or its member ... the latest report in AIS’s Management Insight Series. ... case studies of two insurers — Horizon Healthcare Services, ...
Breaking Medicine News(10 mins):Health News:Industry Leaders Rob and Tiffanie Moffitt Join mynt 2Health News:Lactic Acid Market Worth $3,577.5 Million & Polylactic Acid Market Worth $4,840.1 Million by 2019 – New Report 2Health News:Lactic Acid Market Worth $3,577.5 Million & Polylactic Acid Market Worth $4,840.1 Million by 2019 – New Report 3Health News:Recently Featured in Current Pedorthics: Bunion Bootie, the Very Popular Bunion Treatment Splint 2Health News:Recently Featured in Current Pedorthics: Bunion Bootie, the Very Popular Bunion Treatment Splint 3Health News:Financial VP Fights Pesky Bugs with Launch of Biteback Sports Insect Shield® Golf Apparel 2Health News:New AIS Report Highlights Two Case Studies of Bundled Payment Models 2
... HealthDay Reporter , MONDAY, Nov. 22 (HealthDay News) -- Children ... risk for experiencing a stroke compared with those whose parents, ... The finding stems from a survey of more than 13,000 ... when they were young children or adolescents. "I certainly ...
... mouse is helping researchers learn whether more muscle improves ... looking for ways to counteract the unhealthy effects of ... Medical College of Georgia Vascular Biology Center and co-director ... Obesity increases the risk for cardiovascular disease as well ...
... patients whose treatment is delayed not only become sicker than ... dollars more in care over the first several years of ... get people into care early because they will stay healthier ... M.D., M.P.H., an associate professor of medicine in the Division ...
... , MONDAY, Nov. 22 (HealthDay News) -- The pain of ... foot, elbow and lower back pain, a new study has ... osteoarthritis (OA) patients, aged 45 to 79, about pain in ... ankle or foot. Low back pain was significantly associated ...
... known for his groundbreaking work in biochemistry, received the ... joins an illustrious list of laureates which includes 15 ... his research related to artificial leaves and its creation ... research. This Medal has been awarded since 1921 to ...
... SATURDAY, Nov. 20 (HealthDay News) -- Kidney failure patients ... prescribed had significantly better heart function, overall health and ... finding stems from an analysis that compared the impact ... treatments per week, for three to four hours per ...
Cached Medicine News:Health News:Children of Divorce Face Twice the Lifetime Risk of Stroke: Study 2Health News:Children of Divorce Face Twice the Lifetime Risk of Stroke: Study 3Health News:Fat yet muscular mouse provides clues to improving cardiovascular health 2Health News:For HIV-positive patients, delayed treatment a costly decision 2Health News:Top Swedish scientist professor Bertil Andersson awarded prestigious Wilhelm Exner Medal in Vienna 2Health News:Top Swedish scientist professor Bertil Andersson awarded prestigious Wilhelm Exner Medal in Vienna 3Health News:Top Swedish scientist professor Bertil Andersson awarded prestigious Wilhelm Exner Medal in Vienna 4Health News:Top Swedish scientist professor Bertil Andersson awarded prestigious Wilhelm Exner Medal in Vienna 5Health News:Doubling Frequency of Dialysis May Help Kidney Failure Patients 2Health News:Doubling Frequency of Dialysis May Help Kidney Failure Patients 3
300 L, Racked, 96 tips/rack Recommended for 250 and 300 L pipettes....
... been designed to optimize the accuracy and ... tip products is widely recognized by customers ... been extended over the years and now ... special tips including filter tips, certified pure ...
... a rack for single- and multichannel ... Racks: Can be steam sterilized at ... with an 8 x 12 row ... specifically designed to ensure proper connection ...
... Universal Softfit(tm) Design to fit most ... Compatibility Biohit Electronic (Limited Draw) ... Multi-Channel 5-50ul Capp Aero 50ul ... Titerman 4908 5-50ul Finnpipette Multi-Channel 5-50ul ...
Medicine Products: