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Shionogi Enters Into Exclusive License Agreement With QuatRx Pharmaceuticals To Market Ospemifene
Date:3/2/2010

bothersome moderate to severe symptom of dyspareunia. The first Phase 3 trial for ospemifene met all the co-primary endpoints at a 60 mg dosage, with statistically significant improvements in vaginal dryness and dyspareunia, as well as statistically significant improvement in the proportion of parabasal and superficial cells in the epithelium of vaginal walls and a decline in vaginal pH levels.  Data from the long term safety studies demonstrated that daily doses of 60 mg of ospemifene are well-tolerated.

Robert L. Zerbe M.D., CEO and Co-Founder of QuatRx, said, "QuatRx is very pleased to have completed the comprehensive development program for ospemifene.  Pending regulatory approval, the results of our clinical research for ospemifene indicate that this promising non-estrogen therapy could play a significant role in the treatment of vulvovaginal atrophy in the years ahead.  Shionogi is the ideal company to successfully support the effort to commercialize ospemifene in the U.S. and around the world."

About Post-menopausal Vaginal Atrophy

Post-menopausal vulvovaginal atrophy is a chronic and progressive condition characterized by symptoms including vaginal dryness, sexual pain (dyspareunia) and irritation. Declining estrogen levels during menopause can cause tissues of the va
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SOURCE QuatRx Pharmaceuticals Company
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