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Sequoia Pharmaceuticals Presents In Vitro and First-in-Human Data Supporting Further Development of SPI-256, a Novel Investigational Protease Inhibitor
Date:10/26/2008

also undergoing evaluation in human clinical trials.

"The emergence of our first clinical candidate is an important milestone for Sequoia and indicative of the tremendous progress we've made during the past 12 months," said Steve Skolsky, president and chief executive officer of Sequoia. "We're very pleased at the speed with which we have brought our drug candidates to human trials, following the successful filing of two investigational new drug applications in 2007, one for SPI-256, and a second for our proprietary pharmacokinetic enhancer, SPI-452."

About Sequoia Pharmaceuticals, Inc.

Sequoia Pharmaceuticals discovers and develops unique antiviral drugs that potently inhibit the most prevalent form of viruses and prevent the emergence of drug-resistant viruses. Sequoia's core expertise of structure- and target-based design facilitates the efficient discovery of multiple NCE's with a small team of discovery scientists. Its current drug pipeline focuses on HIV/AIDS and HCV-induced hepatitis. Sequoia is also developing a unique series of pharmacokinetic enhancers (PKEs) which have potential application in a wide range of therapy areas, including use in combination with currently marketed and experimental antiviral therapies.

Sequoia Pharmaceuticals has two investigational new drug applications (INDs) filed with the Food and Drug Administration. The first IND is for SPI-256, an HIV protease inhibitor in Phase 1 clinical development. The second IND is for SPI-452, a pharmacokinetic enhancer in Phase 1 clinical development.


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