Navigation Links
Sequella Presents Data on Synergy Between Investigational New TB Drugs SQ109 and TMC207
Date:10/28/2008

Study results to be presented at 2008 ICAAC/IDSA Joint Meeting

ROCKVILLE, Md., Oct. 28 /PRNewswire/ -- Sequella, Inc., a clinical-stage biopharmaceutical company focused on commercializing products to treat infectious diseases of epidemic potential, announces the successful demonstration of synergistic activities and improvement of minimal inhibitory concentration (MIC) resulting from in vitro combination studies of Sequella lead TB drug candidate, SQ109, and Tibotec's lead TB drug candidate, TMC207. Both drug candidates are currently undergoing human clinical studies.

Results from these studies were presented on October 28th at the Interscience Conference on Anti-Microbial Agents and Chemotherapeutics (ICAAC) and Infectious Disease Society of America (IDSA) joint meeting in Washington, DC.

The collaboration between Sequella and Tibotec was designed to investigate in vitro interactions of SQ109 for synergistic, additive, or antagonistic activity in the presence of TMC207, using a number of clinical and laboratory strains of both drug sensitive and drug resistant M. tuberculosis (MTB). In vitro interactions investigated included synergy studies, rate of killing, post antibiotic effect and intracellular activity against MTB in macrophages.

There were no antagonistic activities observed in any combination studies. SQ109 and TMC207 in combination were either synergistic or additive with the various MTB strains and showed increased rate of killing, enhanced post antibiotic effect and intracellular killing activity. Results showed that the SQ109 and TMC207 drug combination was extraordinary potent, with greater than 90% kill of MTB as early as 1 day after drug combination exposure.

Dr. Carol Nacy, CEO of Sequella said, "We are very pleased to be collaborating with Tibotec, a world renowned product development organization, and we look forward to our continuing partnership to examine these important drug synergies in animal models
'/>"/>

SOURCE Sequella, Inc.
Copyright©2008 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2

Related medicine technology :

1. Topical Treatment for Cold Sores Achieves Efficacy of Oral Drugs; Represents Paradigm Shift in the Treatment of Skin Infections
2. Nuvo Research presents positive Phase III study results for Pennsaid at leading rheumatology conference
3. Sequoia Pharmaceuticals Presents In Vitro and First-in-Human Data Supporting Further Development of SPI-256, a Novel Investigational Protease Inhibitor
4. Mpex Pharmaceuticals Presents New Data on MP-376 in Cystic Fibrosis
5. Millennium Presents New Data on Investigational Drugs for Novel Cancer Targets at EORTC-NCI-AACR Symposium
6. Nventa Presents Findings on Proprietary Toll-like Receptor 3 (TLR3) Agonist, Poly-ICR, at World Vaccine Congress
7. Prometheus Presents Findings From Development of PROMETHEUS(R) IBS Diagnostic, First Blood Test for IBS, at ACG Annual Scientific Meeting
8. Alba Therapeutics Presents New Data for Larazotide Acetate at the 2008 American College of Gastroenterology Annual Scientific Meeting
9. Ardea Biosciences Presents Preclinical Anti-Inflammatory Data on its Lead MEK Inhibitor, RDEA119, at the ACG 2008 Annual Meeting
10. Orexigen(R) Therapeutics Presents Data on Its Proprietary Formulation of Naltrexone Sustained Release (SR) Used in Contrave(R)
11. Access Pharmaceuticals Presents New Data on the Companys Angiolix(R) Therapeutic Monoclonal Antibody

Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/9/2009)...rstCall/ -- Caliper Life Sciences, Inc. (Nasdaq: ...or drug discovery and life sciences research, toda...nd Services (CDAS) unit has been awarded a new fun...t with the Environmental Protection Agency (EPA) f...task order increases the cumulative funding Calipe...
(Date:11/7/2009)...-- Most patients with hereditary angioedema (HAE) ...E attack giving the patients sufficient time to in...ated with that attack, according to survey finding...Allergy, Asthma & Immunology (ACAAI) Annual Me...ue and nausea, which occur frequently before an ac...
(Date:11/6/2009).../ -- Recession in domestic and international marke...e Products in the first quarter of fiscal year 201...pushed Allied into a loss for the quarter. The ne...tive 9 cents per share, compared to a net profit t...share. ,, Sales fell about 21 percent in the q...
Breaking Medicine Technology:Caliper Awarded New Task Order for EPA ToxCast Program 2Caliper Awarded New Task Order for EPA ToxCast Program 3Prodromal Symptoms Warn of Hereditary Angioedema Attacks, Give Patients Time to Start Therapy and Decrease Morbidity 2Prodromal Symptoms Warn of Hereditary Angioedema Attacks, Give Patients Time to Start Therapy and Decrease Morbidity 3Recession Continues to Depress Sales at Allied Healthcare Products 2Recession Continues to Depress Sales at Allied Healthcare Products 3Recession Continues to Depress Sales at Allied Healthcare Products 4Recession Continues to Depress Sales at Allied Healthcare Products 5Recession Continues to Depress Sales at Allied Healthcare Products 6NIAID launches 2009 H1N1 influenza vaccine trial in pregnant women 56679 1NIAID launches 2009 H1N1 influenza vaccine trial in pregnant women 56679 2New robot travels across the seafloor to monitor the impact of climate change on deep sea ecosystems 9856 1New robot travels across the seafloor to monitor the impact of climate change on deep sea ecosystems 9856 2New robot travels across the seafloor to monitor the impact of climate change on deep sea ecosystems 9856 3New robot travels across the seafloor to monitor the impact of climate change on deep sea ecosystems 9856 4Medicine wheel model for nutrition shows promise for control of type 2 diabetes 9854 1Medicine wheel model for nutrition shows promise for control of type 2 diabetes 9854 2
...etection rate for CHD improved from 78% to 100% wi... IRVINE, Calif., Nov. 14 Masimo (Nasdaq:,MASI), ... Motion and Low,Perfusion pulse oximetry, reported...dy demonstrates the ability of Masimo SET Perfusio...art defects (CHD) in newborns with,duct-dependent ...
...study compared FORTEO and the currently approved t...oid-Induced Osteoporosis, INDIANAPOLIS, Nov. 14 ...al of Medicine, showed that in patients with,gluco..., teriparatide [rDNA,origin] injection) significan...MD) from baseline (8.2 percent) compared to Fosama...
Other Medicine Technology:New Research Shows Masimo Perfusion Index (PI) Effective in the Noninvasive Detection of Congenital Heart Defects (CHD) in Newborns 2New Research Shows Masimo Perfusion Index (PI) Effective in the Noninvasive Detection of Congenital Heart Defects (CHD) in Newborns 3New Research Shows Masimo Perfusion Index (PI) Effective in the Noninvasive Detection of Congenital Heart Defects (CHD) in Newborns 4FORTEO(R) Increased Spine Bone Mineral Density in Patients with Glucocorticoid-Induced Osteoporosis 2FORTEO(R) Increased Spine Bone Mineral Density in Patients with Glucocorticoid-Induced Osteoporosis 3FORTEO(R) Increased Spine Bone Mineral Density in Patients with Glucocorticoid-Induced Osteoporosis 4FORTEO(R) Increased Spine Bone Mineral Density in Patients with Glucocorticoid-Induced Osteoporosis 5FORTEO(R) Increased Spine Bone Mineral Density in Patients with Glucocorticoid-Induced Osteoporosis 6
(Date:11/9/2009)... To enhance the career development of...late laboratory research into clinical medicine, A...new online social-networking site called CTSciNet,... , (PRWEB) November 6, 200...s career development initiative, CTSciNet is an ...
(Date:11/9/2009)... A new website providing support and ...r has been launched at TheFaceofLungCancer.org. Th...ors while distilling important information and adv... (PRWEB) November 9, 2009 -- With he...uare, and in recognition of November’s desig...
(Date:11/9/2009)... One of the top cosmetic surgeons in ...uo; Benjamin Bassichis, MD, FACS, has recently pub...ial rejuvenation in the Facial Plastic Surgery Cli...cial Plastic and Reconstructive Surgeon, Dr. Bassi...nd long-term facial filler treatments to achieve t...
(Date:11/9/2009)...na University study involving 2,453 women ages 18 ...ity alone or with a partner contributed to higher ...rsonal lubricants have long been recommended to wo...nd to reduce the risk of vaginal tearing, yet stri...,s use of lubricants or associated vaginal symptom...
(Date:11/8/2009)...Praises House Passage of Health Care Reform Bill ...are, improve coverage for all Americans ,, HAR... ,, SUMMARY: Last night the United States Hou...reform legislation that would strengthen Medicare ...mpanies that prices millions of Americans out of a...
Breaking Medicine News(10 mins):Health News:Social Network for Translational Scientists Launched 2Health News:Social Network for Translational Scientists Launched 3Health News:Social Network for Translational Scientists Launched 4Health News:The Face of Lung Cancer Support and Information Website Launches to Increase Awareness and Advocacy 2Health News:The Face of Lung Cancer Support and Information Website Launches to Increase Awareness and Advocacy 3Health News:Dallas Facial Plastic Surgeon Publishes Cutting-Edge Novel Approach To Facelift Technique 2Health News:Indiana U. at APHA: Studies about why men and women use lubricants during sex 2Health News:Indiana U. at APHA: Studies about why men and women use lubricants during sex 3Health News:AARP Pennsylvania Key Vote News Alert 2Health News:AARP Pennsylvania Key Vote News Alert 3Health News:AARP Pennsylvania Key Vote News Alert 4
...rsity shows that circadian rhythms dominate all li... mammals are according to this daily rhythm. It di...nes were affected by the natures clock. It was ear...w study emphasises oscillation as a basic property...
...d to climb those five floors of stairs, or pump ir...pick up a racy novel like those written by Jilly C...ore Borders, suggests that simply reading a racy n...eople normally burn around one calorie per minute ...
...ssed to aborting over 250 female fetuses, adding h...rried out at his nursing home over the last decade...he police raided the Buala Nursing Home in Pataudi...n 250 unborn female fetuses and has lost count of ...
...transferred back to the LA prison where she is ser...e facilitys medical ward. Jail authorities...fter her stay in the Twin Towers Correctional Faci...ury Regional Detention Centre. However, it...
... lower half of the body could get a second lease o...ment being offered by a hospital here. The ...ly perfected the art of making paraplegics walk ag...LISTR) - the research and development division of ...
... Studies have found in a study of mice that repeat... everyday life, may contribute to the accumulatio...is a hallmark of Alzheimers disease. The r... factor. A long-term study of about 800 me...
Other Medicine News:Health News:Life Functions Governed by Circadian Rhythms-new Research 2Health News:Life Functions Governed by Circadian Rhythms-new Research 3Health News:Quack of Gurgaon Confesses of Aborting 250 Female Fetuses 2Health News:Stem Cell Treatment Offers Hope for Paralysis Patients 2Health News:Stem Cell Treatment Offers Hope for Paralysis Patients 3Health News:Emotional Stress Could Be a Factor in Causing Alzheimers: Study 2
Liquichek Sedimentation Rate Control
Liquichek Hematology Control (A)
Liquichek Seroconversion Panels
Liquichek Lipids Control
Medicine Products: