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Sepsis and Septic Shock on the Rise, Affecting Younger Patients
Date:1/11/2010

hormone of calcitonin and is not normally present in the bloodstream of a healthy individual. PCT is released from multiple organs when there is a systemic bacterial infection. The blood plasma level of PCT is a reflection of the severity of bacterial infection, ranging from slightly elevated concentrations in infections with minor systemic inflammatory response to very high values in cases of severe sepsis and septic shock. Since the first report in 1993 on the association of serum PCT levels with bacterial infection,(3) there is a solid body of evidence in the literature on its utility for early diagnosis and prognosis, monitoring the clinical course as well as its utility to guide therapy.(4)

References

  1. Balk, R. Severe Sepsis and Septic Shock: Definitions, Epidemiology, And Clinical Manifestations; Critical Care Clinics, Volume 16, Issue 2, Pages 179-192.
  2. Roberts RR, Hota B, Ahmad I, Scott RD II, Foster SD, Abbasi F, Schabowski S, Kampe LM, Ciavarella GG, Supino M, Naples J, Cordell R, Levy SB, Weistein RA. Hospital and Societal Costs of Antimicrobial-Resistant Infections in a Chicago Teaching Hospital: Implications for Antibiotic Stewardship. Clin Infect Dis 2009:49 (15 October):1175-84.
  3. Assicot M, Gendrel D, Garsin H, et al. High serum procalcitonin concentrations in patients with sepsis and infection. Lancet 1993; 341: 515-518.
  4. Christ-Crain M, Muller B. Procalcitonin in bacterial infections - hype, hope or more or less? Swiss Med Wkly 2005; 135: 451-460.

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