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Semafore's PI3 Kinase Inhibitor SF1126 is Active Against Tumor and Tumor Cells and Synergizes with Standard Chemotherapy Agents
Date:10/26/2007

superfamily, including DNA-PK and mTOR. A major factor in tumor resistance to approved chemotherapy agents is thought to be the activation of the PI3K/PTEN pathway. As a result, it is thought that inhibiting this pathway, via SF1126, could cause the resetting of sensitivity to approved agents and exhibit synergistic anticancer effects.

About Semafore

Semafore is a clinical stage drug discovery and development company focused on small molecule modulators of the PI3 kinase and PTEN cell signaling pathway, a promising target pathway for multiple disorders, including the company's focus--cancer. Semafore is one of the first biopharmaceutical companies to focus on both PI3K and PENN and has successfully discovered and is developing a portfolio of drug candidates addressing these targets. For more information see the company's website at http://www.semaforepharma.com.

Contact: David Schull or Timothy Engel

Russo Partners, LLC

212.845.4271

david.schull@russopartnersllc.com

timothy.engel@russopartnersllc.com


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SOURCE Semafore Pharmaceuticals Inc.
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