Navigation Links
Semafore Broadens Pipeline With Multi-Targeted Kinase Inhibitors
Date:8/26/2008

aft models demonstrated 81 percent tumor growth inhibition. SF2506 testing resulted in 93 percent tumor growth reduction in the same model.

"Semafore's proprietary kinase scaffold and our new multi-targeted kinase inhibitors add significant value to our pipeline," said Dr. Dennis McKeever, Semafore's Chief Executive Officer. "In addition to inhibiting all Class I isoforms of PI3K, our compounds SF2506 and SF2523 block additional key kinases which is in keeping with the multi-targeting philosophy behind other recent successful molecularly targeted agents."

About Semafore

Semafore is a clinical stage drug discovery and development company focused on small molecule modulators of the PI3 kinase and PTEN cell signaling pathway, a promising target pathway for multiple disorders, including the company's focus -- cancer. Semafore is a leader in the development of PI3K inhibitors and one of the first biopharmaceutical companies to focus on both PI3K and PTEN. The company has successfully discovered and is developing a portfolio of drug candidates addressing these targets.

About SF1126

There is a strong and significant biological rationale for developing PI3 kinase inhibitors to treat cancer. Phosphoinositide 3-kinase (PI3K) is the gate keeper of one of the major pathways of intracellular signal transduction that regulates cell growth, proliferation, angiogenesis, migration, differentiation, and survival. Dysregulation of the PI3K signaling pathway is believed to play an integral role in the genesis of many cancers including both solid tumors and hematologic malignancies. Cancer research and pharmaceutical drug development efforts have been aimed at discovering and developing therapeutics that inhibit PI3K with the hope of controlling cancer cell division, angiogenesis (the formation of new blood vessels for cancer growth), proliferation and metastasis. Semafore's innovative PI3K inhibitor, SF1126, promises such hope for cancer patients. '/>"/>

SOURCE Semafore Pharmaceuticals Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Semafore Pharmaceuticals Reports Positive Interim Results from a Phase I Study of SF1126, a Targeted Pan-PI3K Inhibitor, in Patients with Advanced Solid Tumors
2. Semafores PI3 Kinase Inhibitor SF1126 is a Vascular Targeted Conjugate in Phase I Clinical Trials in Solid Tumors and Multiple Myeloma
3. Semafores SF1126 Exhibits Antitumor and Antiangiogenic Activity
4. Semafores PI3 Kinase Inhibitor SF1126 is Active Against Tumor and Tumor Cells and Synergizes with Standard Chemotherapy Agents
5. FDA Broadens US Indication for Once-Yearly Reclast(R) as Only Osteoporosis Treatment Approved for Prevention of Fractures After a Hip Fracture
6. Medarex Highlights Strength in Antibody Development and Underlying Pipeline Strategy at R&D Day Event in New York City
7. The Ocean Becomes a Pipeline To A Cure for Cystic Fibrosis
8. Strength and Innovation of Novartis Oncology Products and Pipeline With Potential to Improve Patient Treatment Demonstrated by More Than 170 Abstracts at ASCO Annual Meeting
9. Intercell AG to Acquire Iomai Corporation to Expand Late Stage Product Pipeline and Strengthen Leadership in Vaccine Innovation
10. Shire Enhances its Orphan Drug Pipeline With the Acquisition of a New Clinical Candidate for Metachromatic Leukodystrophy
11. SuperGen to Highlight Oncology Pipeline Data in Multiple Presentations at the AACR Annual Meeting
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/2/2015)... -- Edison Investment Research, a leading ... full coverage of Abzena  Highlights of ... biotech analysts Christian Glennie and Dr ... offers a range of key services and technologies ... biological products. Antitope (immunogenicity testing, protein engineering, cell ...
(Date:3/2/2015)... Mount Elizabeth Novena Hospital will soon become the first ... treat cancer using the TrueBeam™ STx system for radiotherapy ... VAR ).  At a Grand Opening event last Friday, ... of treatment including radiosurgery, a precise method of using ... from outside the body, without performing surgery.  ...
(Date:3/2/2015)... -- Valencia Technologies Corporation (" Valencia ") ... small device for the treatment of high blood pressure ... double-blinded, controlled trial are compelling and provide the Company ... succeed in a large U.S. trial for FDA approval. ... Valencia has successfully raised more than 2.2 ...
Breaking Medicine Technology:Edison Initiates Coverage on Abzena 2Mount Elizabeth Novena Hospital to Deliver First TrueBeam STx Radiosurgery Treatments in Singapore 2Mount Elizabeth Novena Hospital to Deliver First TrueBeam STx Radiosurgery Treatments in Singapore 3Valencia Technologies Implants its 48th Patient, Continues Equity Crowdfunding 2
... , RYE, N.Y., Nov. 19 Curemark LLC, ( ... focused on the treatment of neurological diseases, announced that the ... for CM-AT, its autism treatment, at three additional clinical trial ... Center in Phoenix, Arizona (SARRC); Pennsylvania State University,s Pediatric Clinical ...
... , PARIS, Nov. 19 Radiall and Integral ... medical applications, signing an agreement to confirm this new alliance. ... a long period of time, the company has established relationships ... OEMs supplying diagnostic equipment. , Integral Process is a ...
Cached Medicine Technology:Curemark Opens Patient Enrollment for Autism Treatment at Three More Clinical Trial Sites 2Curemark Opens Patient Enrollment for Autism Treatment at Three More Clinical Trial Sites 3Radiall and Integral Process Sign Agreement 2
(Date:3/2/2015)... Today the Brain Injury Association of America (BIAA) ... recognize and support the more than 5.3 million Americans who ... leads the nation in observing Brain Injury Awareness Month by ... theme for the 2015 to 2017 campaign is: Not Alone. ... educating the general public about the incidence of brain injury ...
(Date:3/2/2015)... GBCHealth, a prominent business coalition ... activities and investments in global health issues, today ... members to serve on the organization’s Board of ... Strategist and Co-founder of Partners In Health, and ... Abbasi, General Manager of Global Health and Medical ...
(Date:3/2/2015)... Los Angeles, CA (PRWEB) March 02, 2015 ... Jimmy Buffett tickets at the Hollywood Bowl . This ... can add customer appreciation promo code JIMMY-BUFFETT-2015 for added ... celebrate because their favorite performer will be headlining at ... This concert will be on Thursday, October 22nd ...
(Date:3/2/2015)... FL (PRWEB) March 02, 2015 While ... with Title VI of the Civil Rights Act, the ... and hearing loss are bringing light to the value ... statistics reveal that nearly 1 in 20 U.S. children ... in 10 in some major cities.(1) Stratus Video ...
(Date:3/2/2015)... March 02, 2015 ZoomCare announced ... remake American healthcare. Zoom will expand its Portland ... clinics and advanced care studios delivering urgent care, ... services, specialty care and outpatient surgery. With its ... to almost all healthcare needs outside of hospitalization. ...
Breaking Medicine News(10 mins):Health News:Brain Injury Association of America Launches “Not Alone” Campaign for Brain Injury Awareness Month 2Health News:Dr. Paul Farmer and Leaders from Chevron, Johnson & Johnson and Merck Join GBCHealth’s Board of Directors 2Health News:Dr. Paul Farmer and Leaders from Chevron, Johnson & Johnson and Merck Join GBCHealth’s Board of Directors 3Health News:Dr. Paul Farmer and Leaders from Chevron, Johnson & Johnson and Merck Join GBCHealth’s Board of Directors 4Health News:Dr. Paul Farmer and Leaders from Chevron, Johnson & Johnson and Merck Join GBCHealth’s Board of Directors 5Health News:Cheap Jimmy Buffett Tickets Hollywood Bowl: Ticket Down Slashes Prices on Jimmy Buffett Tickets at the Hollywood Bowl in Los Angeles/Hollywood, CA 2Health News:Stratus Video Addresses Inadequate Language Interpreting for 2.4 Million U.S. Children 2Health News:Stratus Video Addresses Inadequate Language Interpreting for 2.4 Million U.S. Children 3Health News:Stratus Video Addresses Inadequate Language Interpreting for 2.4 Million U.S. Children 4Health News:ZoomCare Announces 28-Location, On-Demand Neighborhood Health Campus 2Health News:ZoomCare Announces 28-Location, On-Demand Neighborhood Health Campus 3
... people in order to show- how eating patterns can stop you ... aged 60 or over living in many countries . They ... ate lots of green leafy vegetables, beans, olive oil, nuts and ... meat and sugar was also linked to keeping a smoother skin.// ...
... inhibitor ramipril, used for the treatment of hypertension, can ... thereby lowering the risk of stroke and myocardial infarction ... Heat Outcome Prevention Evaluation (HOPE) study showed the drug ... broad range of patients – those with normal or ...
... chronic bronchitis, research has found. It has been thought that ... survey of almost 16,000 people aged 18 to 47 ... opposite. ,The researchers found that the disease affects ... Young smokers were particularly at risk, and men were more ...
... occur in several forms, but systemic lupus erythematosus (SLE)--usually ... It is an incurable disease marked by inflammation and ... the joints, skin, heart, kidney and central nervous system. ... mistakenly attacks the body's own tissue. ,New research ...
... to believe that a gene-based treatment for heart disease may ... blood vessels in hearts with severe hardening of the arteries ... patients suffering with heart disease.// ,Treatment options for ... that open blocked arteries and improve blood flow to the ...
... A new study from Brazil has found that coffee ... blood levels of cholesterol and the protein homocysteine.High levels ... disease. Some of the compounds, called terpenoids, are known ... Right, of Marylandl University Hospital ,US, explained that "it ...
Cached Medicine News:Health News:New light on Cardiology 2
... Trellis Infusion Catheter enables the physician to ... fluid, and disperse the agent by means ... Trellis is a multi-lumen catheter with two ... and infusion holes located between these balloons. ...
... OptiEdge offers design innovations that ensure outstanding ... handling. The biostable acrylic material of the ... the patented OptiEdge is designed to both ... of contact with the posterior capsule; and ...
... posterior chamber lenses are optical implants for ... in the visual correction of aphakia in ... The optical portion consists of a high ... have biconvex optics and supporting haptics of ...
... an intraocular lens that doesn't stop ... natural human lens, the new ACRYSOF® ... high-energy blue light. But while it ... your patient's view. That's just as ...
Medicine Products: