Navigation Links
Selexys Pharmaceuticals Initiates SUSTAIN Phase 2 Clinical Trial in Sickle Cell Patients with Pain Crises
Date:8/19/2013

OKLAHOMA CITY, Aug. 19, 2013 /PRNewswire/ -- Selexys Pharmaceuticals Corporation, a privately held biopharmaceutical company that is developing therapies to treat inflammatory and thrombotic diseases, today announced that enrollment has been initiated in SUSTAIN, a Phase II, multicenter, randomized, placebo-controlled, double-blind, 12-month study to assess safety and efficacy of the anti-P-selectin monoclonal antibody SelG1 with or without hydroxyurea therapy in sickle cell disease patients with sickle cell-related pain crises.

The SUSTAIN trial will randomize approximately 174 patients to receive high dose SelG1, low dose SelG1 or placebo in the presence or absence of hydroxyurea therapy, the current standard of treatment. The study will examine the effectiveness of SelG1 in reducing the rate of sickle cell-related pain crises in each active dose level as compared to placebo. The study will be conducted in approximately 60 centers throughout the U.S. Further information on this trial is available at clinicaltrials.gov (NCT01895361).

"With the limited therapies available to patients with sickle cell disease, this trial with a novel P-selectin inhibitor is particularly exciting. Not only does it have the potential to improve the clinical outcomes in patients, its effects may be additive or synergistic with those of hydroxyurea, the only drug currently approved by the FDA for treatment of complications due to sickle cell disease," stated Dr. Kenneth Ataga, Lead Investigator and Associate Professor of Medicine in the Division of Hematology/Oncology, University of North Carolina at Chapel Hill.

"Data from preclinical sickle cell disease models suggest that blockade of P-selectin effectively prevents the painful stoppage of circulation in small blood vessels called vasoocclusion and maintains patent
'/>"/>

SOURCE Selexys Pharmaceuticals
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Selexys Pharmaceuticals Completes $23M Equity Financing and Signs Agreement With Global Pharmaceutical Company
2. Cadence Pharmaceuticals Comments on USPTOs Non-Final, Initial Office Action on Reexamination of Patent
3. Cadence Pharmaceuticals Appoints Laureen DeBuono to its Board of Directors
4. Inovio Pharmaceuticals Malaria DNA Vaccine Demonstrates Robust Immune Responses in Animal Models
5. Avanir Pharmaceuticals Announces Settlement of NUEDEXTA Patent Litigation with Sandoz
6. Ampio Pharmaceuticals, Inc. Announces Positive Results for Ampion in Osteoarthritis of the Knee Clinical Trial
7. Savient Pharmaceuticals Reports Second Quarter 2013 Financial Results
8. Robbins Arroyo LLP Is Investigating the Directors and Officers of Navidea Biopharmaceuticals, Inc.
9. Avanir Pharmaceuticals Announces Diabetes Co-Promotion Agreement with Merck
10. AcelRx Pharmaceuticals Reports Second Quarter 2013 Financial Results
11. ANI Pharmaceuticals Announces an Agreement for the Development and Marketing of an Oral Soft Gel Prescription Product with Sofgen Pharmaceuticals
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/23/2015)... Jan. 23, 2015  Now available for sale, The Armor1 ... that prevents ankle sprains by cushioning the ankle from ... securely around the outside of any shoe type and ... while still offering protection against sprains. With customers in ...
(Date:1/23/2015)... Jan. 23, 2015 Cord Blood America, Inc. ( www.cordblood-america.com ... the "Company")  filed a Preliminary Proxy Statement, Schedule 14A, with ... and provides an update for shareholders detailing why a "YES" ... Dear Shareholders, As we reflect upon ...
(Date:1/23/2015)... , Jan. 23, 2015  Mallinckrodt plc (NYSE: ... Directors has approved a share repurchase program. The open-ended ... million of Mallinckrodt plc ordinary shares. ... remain top priorities as we continue to pursue a ...
Breaking Medicine Technology:The Armor1 Ankle Roll Guard is the New Breakthrough Solution for Ankle Sprain Prevention! 2Cord Blood America Announces Preliminary Proxy Filing and Details Why a "YES" Vote to Increase Authorized Shares Is Requested 2Cord Blood America Announces Preliminary Proxy Filing and Details Why a "YES" Vote to Increase Authorized Shares Is Requested 3Cord Blood America Announces Preliminary Proxy Filing and Details Why a "YES" Vote to Increase Authorized Shares Is Requested 4Mallinckrodt plc Announces Share Repurchase Program 2Mallinckrodt plc Announces Share Repurchase Program 3Mallinckrodt plc Announces Share Repurchase Program 4
... VR Business Sales, Mergers & Acquisitions Charlotte, N.C. ... of Salisbury, NC.  This durable medical equipment provider specializes ... manual and power wheelchairs and scooters. "Penrod ... equipment providers I,ve seen.  The business generated a lot ...
... 2011 ,The " Global Diagnostic ... & Forecasts from 2010 to 2016 " analyzes and ... such as North America, Europe, Asia, and Rest of the ... in-depth TOC on Global Diagnostic Imaging (CT, MRI, X-Ray & ...
Cached Medicine Technology:MarketsandMarkets: Global Diagnostic Imaging Market Estimated to Reach $26.6 Billion by 2016 2MarketsandMarkets: Global Diagnostic Imaging Market Estimated to Reach $26.6 Billion by 2016 3
(Date:1/22/2015)... Gabe’s Chemo Duck Program is pleased to announce the release ... for kids with cancer. The Chemo Duck App, available on iTunes ... enjoyable games to help children of all ages living with cancer ... keep kids entertained, educated and at ease while waiting for clinic ...
(Date:1/22/2015)... EAGAN, Minn. (PRWEB) January 22, 2015 Blue ... discover those Minnesotans who exemplify what it means to “Live ... a chance for people to share their stories about how ... adversity or simply inspired others by living in the moment. ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 Thousand of ... Medical Care recalled its GranuFlo and NaturaLyte dialysis concentrates ... underway in U.S. District Court, District of Massachusetts, Bernstein ... 20th, the Court has remanded a case filed by ...
(Date:1/22/2015)... 22, 2015 A study recently ... flagship journal Medicine & Science in Sports & ... may help reduce gastrointestinal (GI) problems associated with ... Participants in the double-blind, placebo-controlled study took 10 ...
(Date:1/22/2015)... Payday lending practices in four southern states worsen ... to the states that permit them, according to a ... Race and Wealth. , While they generate hundreds of ... the same time substantially depress economic activity, according to ...
Breaking Medicine News(10 mins):Health News:Chemo Duck Launches First App Ever Created for Kids with Cancer 2Health News:Chemo Duck Launches First App Ever Created for Kids with Cancer 3Health News:Blue Cross and Blue Shield of Minnesota to Showcase “Faces of Fearless” 2Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 2Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 3Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 4Health News:Study Shows Kyowa Hakko’s L-Citrulline May Help Reduce Gastrointestinal Injury During Strenuous Exercise 2Health News:Study Shows Kyowa Hakko’s L-Citrulline May Help Reduce Gastrointestinal Injury During Strenuous Exercise 3Health News:Howard University Spotlights the Economic Impact of Payday Lending in Southern States 2
... dismissed by health officials, following the negative results from analysis// ... H5N1 virus. ,Officials belonging to the health department ... outbreak of bird flu has been reported so far, based ... country. ,All necessary precautionary measures have been taken ...
... March 2006 online issue of BMC Public Health focuses on ... in Vietnam and the incidence of prostate cancer (CaP).// This ... linked to CaP. ,However by Dr. Leavy and ... two. Between 2001 and 2002, 606 men with CaP from ...
... their concern over the apparent increase in preterm births ... in February. // ,The study found that preterm ... The study found that even among low risk women aged ... ,The study also showed that assisted conceptions, multiple pregnancies, ...
... study published in the New Zealand Medical Journal says ... middle-aged adults are increasing at an alarming rate. // ... the Heart Foundation and colleagues, shows that the death ... especially in Maori and lower-socioeconomic groups. ,Heart disease ...
... Churchill and Ernest Hemingway. We are talking about the Panama ... woven from palm fibres, considered a status symbol for men ... Panama hats are in worldwide demand and numerous German milliners ... ,"These days when people want to treat themselves to ...
... biological weapons is not isolated it has been categorized in ... to spread, kill effectively and call for special actions by ... hope by Vince Fischetti’s laboratory at Rockefeller University which suggests ... anthrax infections and even decontaminate areas in which anthrax spores ...
Cached Medicine News:Health News:Rising Number of Preterm Births Cause Concern 2Health News:Panama hat making a slow comeback 2
... The innovative PoleStar N20, exclusively distributed ... intra-operative MRI. Combining intra-operative imaging ... registration-free system, PoleStar N20 is one ... available today. , , Exceptional image ...
... II™ single use automatic clip ... clips., ,The Auto Suture™ ... application in many types of ... and other tubular structures and ...
... The Auto Suture™ Powered LDS™ single use ... tissue within the cartridge jaw and a ... two closed staples. , ,The Auto ... titanium staples have application in abdominal, gynecological, ...
... The LIGACLIP Clip Applier is a ... metallic ligating clips. This instrument is used ... produced from either 316L stainless steel or ... ligation of tubular structures where a nonabsorbable ...
Medicine Products: