Navigation Links
Selexys Pharmaceuticals Initiates Enrollment in Phase I Clinical Study of SelG1
Date:5/4/2011

OKLAHOMA CITY, May 4, 2011 /PRNewswire/ -- Selexys Pharmaceuticals announced today that it has initiated enrollment in a Phase I clinical study of its lead compound, SelG1, a humanized anti-P-selectin antibody.  

The placebo-controlled, double-blind, first-in-human, ascending single dose and multiple dose study of SelG1 will enroll approximately 30 healthy subjects. This study will evaluate the safety and pharmacology of SelG1 prior to advancement into a Phase II trial in patients with sickle cell disease.

"This Phase I study represents the first step in understanding the potential of SelG1 to address the unmet medical need in sickle cell disease and we are excited to initiate the clinical development of this novel compound," said Dr. Scott Rollins, Selexys President and CEO. "This Phase I trial represents a key milestone for Selexys as we transition from a preclinical to a clinical development stage biopharmaceutical company."

In 2008, Selexys received orphan-drug designation for SelG1 from the Food and Drug Administration Office of Orphan Products Development for the treatment of vasoocclusive crisis, a severe and painful complication of sickle cell disease. Orphan drug designation is awarded to therapeutics with the potential for safe and effective treatment diagnosis or prevention of rare diseases and disorders that affect fewer than 200,000 people.

About SelG1

SelG1 is an investigational humanized monoclonal antibody directed against P-selectin, a key member of the adhesion molecule family known as the selectins. In preclinical studies, inhibition of P-selectin has been shown to effectively prevent vasoocclusion by blocking critical cell-cell interactions that drive this process. Therapeutic blockade of P-selectin may therefore reduce vasoocclusion and subsequent crises in patients with sickle cell disease.

"SelG1 represents a first-in-class therapeutic approach for the treatment of sickle cell disease
'/>"/>

SOURCE Selexys Pharmaceuticals
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2

Related medicine technology :

1. Aires Pharmaceuticals Appoints Edwin L. Parsley as Chief Medical Officer
2. Keryx Biopharmaceuticals, Inc. Prices Common Stock Offering
3. MHPA Center for Best Practices Receives Sponsorship from Ortho-McNeil Janssen Pharmaceuticals, Inc. to Improve Medicaid Quality, Care Coordination for Serious Mental Illness
4. Arena Pharmaceuticals to Host Business and Financial Update Conference Call and Webcast on Tuesday, May 10
5. Auxilium Pharmaceuticals to Present at the Bank of America Merrill Lynch 2011 Health Care Conference
6. Onyx Pharmaceuticals Reports First Quarter 2011 Financial Results
7. Pacira Pharmaceuticals, Inc. Announces Timing for First Quarter 2011 Financial Results Webcast and Conference Call
8. Anthera Pharmaceuticals Reports 2011 First Quarter Financial Results and Operational Update
9. Jazz Pharmaceuticals Announces First Quarter 2011 Financial Results
10. Idenix Pharmaceuticals to Present at the Bank of America Merrill Lynch 2011 Health Care Conference
11. Isis Pharmaceuticals to Present at the 14th Annual Bank of America Merrill Lynch Health Care Conference
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/28/2015)... , May 27, 2015 Research ... of the "Global Biomedical Metal Market 2015-2019" ... Global Biomedical Metal market to grow at a ... Biomedical metals are being used for a number ... commonly used are stainless steel, titanium-based alloys, cobalt-based ...
(Date:5/28/2015)... , May 28, 2015  The U.S. Department of ... Medical Inc. and Rehab Medical Inc. to resolve a ... the filing of a whistleblower lawsuit by two former ... representatives, under the direction of one of Orbit,s top ... that Orbit could obtain payment from Medicare for electric ...
(Date:5/28/2015)... , May 28, 2015  Merck KGaA, Darmstadt, ... for innovative and top-quality high-tech products in healthcare, ... global collaboration agreement with the fertility technologies expert ... fertility science and helping couples create families. With ... , a global market leader in drugs ...
Breaking Medicine Technology:Global Biomedical Metal Market 2015-2019 with Biomet, Dentsply, Invibio & Wright Medical Group Dominating 2Electric Wheelchair Sellers Agree To $7.5 Million Settlement Of Whistleblower Case Alleging That Company Forged Medical Records As Part Of Scheme To Defraud Medicare 2Electric Wheelchair Sellers Agree To $7.5 Million Settlement Of Whistleblower Case Alleging That Company Forged Medical Records As Part Of Scheme To Defraud Medicare 3Electric Wheelchair Sellers Agree To $7.5 Million Settlement Of Whistleblower Case Alleging That Company Forged Medical Records As Part Of Scheme To Defraud Medicare 4Merck KGaA, Darmstadt, Germany, as Pioneer in Assisted Reproductive Treatments, Takes Leading Role in Fertility Technologies, Announces a Global Collaboration Agreement with Genea Biomedx 2Merck KGaA, Darmstadt, Germany, as Pioneer in Assisted Reproductive Treatments, Takes Leading Role in Fertility Technologies, Announces a Global Collaboration Agreement with Genea Biomedx 3Merck KGaA, Darmstadt, Germany, as Pioneer in Assisted Reproductive Treatments, Takes Leading Role in Fertility Technologies, Announces a Global Collaboration Agreement with Genea Biomedx 4
(Date:5/28/2015)... May 28, 2015 Ticket Down is a ... match between Mexico and Argentina in early September. ... world will compete on the pitch at AT&T Stadium in ... in an international friendly on Tuesday, September 8th at 9 ... nations in the world including some of the most loved ...
(Date:5/28/2015)... Real Time Pain Relief (RTPR), makers of ... their best-selling lotion is now available in a convenient new ... FDA registered OTC pain relief product. It contains a proprietary ... Vera, Arnica, Capsicum, Chondroitin, Emu Oil, Glucosamine, Menthol and MSM. ... 1.25% – to avoid buildup of Substance P in joints ...
(Date:5/28/2015)... GA (PRWEB) May 28, 2015 Hexagon ... Inc. (BHI) , a provider of engineering, spatial data ... generate and analyze thousands of point clouds for urban ... From 2012 to 2014, the BHI Spatial Data Division ... from digital stereo aerial imagery. Collected by a variety ...
(Date:5/28/2015)... IL (PRWEB) May 28, 2015 Cancer ... program exhibited improvements in physical activity, fitness and quality ... Irwin of Yale Cancer Center and Jennifer Ligibel, MD, ... Women’s Cancers, Dana Farber Cancer Institute. The findings will ... Clinical Oncology (ASCO) Annual Meeting in Chicago. ...
(Date:5/28/2015)... The MIT Sloan Center for Information Systems Research ... of the MIT CISR research team interviewed members of ... case study about Healthcare IQ’s business model within the ... ‘Healthcare IQ: Competing as the “Switzerland” of Health Spend ... hospital financial software provider through its evolution to becoming ...
Breaking Medicine News(10 mins):Health News:Mexico vs. Argentina Tickets at AT&T Stadium: Ticket Down Slashes Ticket Prices on Argentina vs. Mexico Presale Tickets at AT&T Stadium for 9/8/15 Friendly Match 2Health News:Mexico vs. Argentina Tickets at AT&T Stadium: Ticket Down Slashes Ticket Prices on Argentina vs. Mexico Presale Tickets at AT&T Stadium for 9/8/15 Friendly Match 3Health News:Real Time Pain Relief Introduces New Four Ounce Pump Bottle for their Popular Pain Relief Lotion 2Health News:Hexagon Geospatial Supports Urban Change Detection Programs in New Mexico 2Health News:Hexagon Geospatial Supports Urban Change Detection Programs in New Mexico 3Health News:LIVESTRONG at the YMCA Program Shows Significant Gains for Cancer Survivor Participants 2Health News:LIVESTRONG at the YMCA Program Shows Significant Gains for Cancer Survivor Participants 3Health News:LIVESTRONG at the YMCA Program Shows Significant Gains for Cancer Survivor Participants 4Health News:Healthcare IQ, the “Switzerland” of Healthcare Spend Analytics, Featured in MIT Case Study 2Health News:Healthcare IQ, the “Switzerland” of Healthcare Spend Analytics, Featured in MIT Case Study 3
... taking too much supplemental calcium are on the rise, ... of the Journal of the American Society Nephrology ... calcium-alkali syndrome is growing in large part because of ... The milk-alkali syndrome arose in the early 1900s ...
... rural southern Asia are exposed every day to unsafe levels ... doubles their risks for cancer, causes cardiovascular disease, and inhibits ... The World Health Organization (WHO) has referred to the situation ... as "the largest mass poisoning of a population in history." ...
... Experts are now recommending that low-dose aspirin therapy to prevent ... younger than 50 and women younger than 60, who have ... aspirin. The new recommendations are based on an analysis ... side effects such as stomach bleeding, and to a much ...
... found if young adults were more fit, 34% of high ... (HealthDay News) -- Low levels of physical activity and fitness ... 20-year study of young adults shows. , The study, released ... print issue of the journal Hypertension , found that ...
... to play in disease detection , TUESDAY, June 1 (HealthDay ... signs of prostate cancer in human urine, adding to the ... friend. , Some scientists have questioned similar reports of dogs ... lead author of this latest study said the findings are ...
... patients who,ve been told to rest and avoid exercise can ... both during and after treatment, according to new national guidelines. ... Biostatistics and a member of the Abramson Cancer Center at ... guidelines at an educational session at the 2010 meeting of ...
Cached Medicine News:Health News:Calcium supplements: too much of a good thing? 2Health News:Researchers offer solutions to poisonous well-water crisis in southern Asia 2Health News:Researchers offer solutions to poisonous well-water crisis in southern Asia 3Health News:Aspirin recommendations changed for many younger diabetic patients 2Health News:Being Young and Sedentary Raises Hypertension Risk Later 2Health News:Being Young and Sedentary Raises Hypertension Risk Later 3Health News:Dog Sniffs Out Prostate Cancer in Small Study 2Health News:New cancer guidelines: Exercise during and after treatment is now encouraged 2Health News:New cancer guidelines: Exercise during and after treatment is now encouraged 3
... provides high quality ventilation and monitoring ... technologies of the AV2+ ventilator, breathing ... GS user-friendly and intuitive. , ... GS is the perfect introduction to ...
... facilities where space is a premium Fabius ... delivery technologies with an ergonomic and compact ... of the Draeger Infinity patient monitoring range ... environment that is a sound investment into ...
... The S/5 Aespire was developed using ... development close and continuous collaboration ... performance of the 7100 Ventilator with ... system solution designed for clinicians throughout ...
... Wound Dressing is a sterile, single use bundle ... dressing applications. The synthetic matrix absorbs excess ... contours, and entraps slough and necrotic debris within ... strands of the matrix are bound together by ...
Medicine Products: