Navigation Links
Selexis Lubris Partnership Advances Difficult-to-Express Protein Towards Clinic
Date:6/27/2012

GENEVA, June 27, 2012 /PRNewswire/ -- Selexis SA, a global life sciences company for drug discovery, cell line development and scale-up to manufacturing of therapeutic proteins, announced today that its US-based customer, Lubris LLC, has achieved over 1 g/L per liter yield in manufacturing production runs of LUB-13-04 as measured by Lubris' CMO partner. LUB-13-04 is a proprietary construct of the recombinant human protein lubricin (Proteoglycan 4 protein, rLubricin) which is expressed from the SURE CHO-M cell line generated with the Selexis SUREtechnology Platform™. LUB-13-04 is in pre-clinical development for dry eye syndrome and osteoarthritis.

(Logo: http://photos.prnewswire.com/prnh/20120627/LA31604LOGO)

Lubricin is a large endogenous complex glycoprotein composed of 40% carbohydrates, originally identified as a lubricating component of synovial fluid. While lubricin has been most actively evaluated for the treatment for osteoarthritis, it is also being studied in dry eye, dry mouth, surgical adhesions and other unmet medical needs.

"The results from the Selexis/Lubris partnership are quite impressive," said Igor Fisch, PhD, CEO of Selexis SA. "We continue to demonstrate that the SUREtechnology Platform™ has a major impact on the economics of manufacturing biologics by significantly increasing the manufacturing cell line's stability and productivity."

"Recombinant lubricin has been proven to be difficult to express efficiently at levels that ensured commercial viability. This is the first reported case of expression levels exceeding 1 g/L for lubricin (or lubricin-like proteins). We chose Selexis based on its track record for overcoming expression bottlenecks with difficult-to-express proteins, and generating fully documented cell lines used for clinical manufacturing," said Ed Truitt, CEO of Lubris. "These results
'/>"/>

SOURCE Selexis SA
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Scotland-based Innova Partnerships Ltd. Opens Boston Office
2. Medifast Announces International Expansion Into Mexico Through Strategic Partnership with Medix
3. Lilly Expands Strategic Partnership with Chinese Manufacturer Novast to Serve Chinese Patients with High-Quality Branded Generic Medicines
4. HUYA Bioscience International Engages In Partnership With Zhuhai Sanzao Science and Technology Industrial Park
5. Bayer Partnership Delivers Industry-First Dose Management Offering
6. VitaTech Adds New Capacity for Production and Customer Interface, Attributes Growth to Strategic Customer Partnerships
7. Medical Guardian Announces Social Media Partnership with Senior Citizen Charity
8. Rigel Advances Asthma Programs: Two Inhaled Drug Candidates Take Aim at Acute and Chronic Lung Disease
9. Polaris Group Lead Therapeutic Candidate ADI-PEG 20 Demonstrates Potential Anticancer Activity in Various Metastatic Sarcomas and Bladder Cancers That Are Deficient in Key Metabolic Protein, and Enhanced Effects with Combination Therapy in Melanoma
10. Cell Therapeutics Aequus BioPharma Validates its Proprietary GlycoPolymer Technology for the Extension of the Half-life of Therapeutic Protein Drugs
11. Ventana licenses Gen-Probe IP for measuring ERG protein in prostate cancer patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/27/2015)... -- Research and Markets ( http://www.researchandmarkets.com/research/rq47bp/global_pressure ... Pressure Relief Devices Market 2015-2019" report to their ... to grow at a CAGR of 4.41% over the ... Market 2015-2019, has been prepared based on an in-depth ... covers the Americas, and the APAC and EMEA; it ...
(Date:7/27/2015)... , July 27, 2015  QT Vascular Ltd., ... a global company engaged in the design, assembly and ... treatment of vascular disease, has entered into an agreement ... to US$13.14 million convertible bond investment. This funding will ... its growth to the next milestone. ...
(Date:7/27/2015)... July 27, 2015  Array BioPharma Inc. ... for the fourth quarter and full year ... call to discuss those results on Monday, ... Officer will lead the call. ... 464-3927Toll:(765) 507-2598Pass Code: 68380312 Webcast, including Replay ...
Breaking Medicine Technology:Global Pressure Relief Devices Market 2015-2019 with ArjoHuntleigh, Hill-Rom, Paramount Bed Holdings & Stryker Dominating 2QT Vascular Obtains Funding To Boost Growth Through Issuance of up to US$13.14 Million Convertible Bonds 2QT Vascular Obtains Funding To Boost Growth Through Issuance of up to US$13.14 Million Convertible Bonds 3
(Date:7/27/2015)... Church, VA (PRWEB) , ... July 27, 2015 ... ... and Compliance From Step One, **FDAnews Webinar**, Aug. 13, 2015 — 1:30 p.m. ... procedures are one of the first things FDA investigators will look at during ...
(Date:7/27/2015)... ... July 27, 2015 , ... Looking to brush up on all ... Blue Shield of New Jersey has enhanced its Dental webpage with new materials, including ... teeth. , “Horizon is committed to offering our 3.8 million members tools and ...
(Date:7/27/2015)... ... July 27, 2015 , ... Send Word ... and mobile collaboration, announced today the latest software release for its ... other feature enhancements. , This software release gives the widely used online application ...
(Date:7/27/2015)... ... July 27, 2015 , ... In an ongoing program ... to its options. Already an industry leader because of its use of iPad ... the latest successful trends in helping people to overcome addiction and live healthy, ...
(Date:7/27/2015)... NJ (PRWEB) , ... July 27, 2015 , ... Gary ... Jersey. Dr. Breslow is Founder and Medical Director of The Breslow Center in ... the face, breast, and body in Northern New Jersey. The Breslow Center also ...
Breaking Medicine News(10 mins):Health News:FDAnews Announces — Writing Effective Standard Operating Procedures: Ensure Quality and Compliance From Step One Webinar, Aug. 13, 2015 2Health News:FDAnews Announces — Writing Effective Standard Operating Procedures: Ensure Quality and Compliance From Step One Webinar, Aug. 13, 2015 3Health News:FDAnews Announces — Writing Effective Standard Operating Procedures: Ensure Quality and Compliance From Step One Webinar, Aug. 13, 2015 4Health News:Thinking about a Dental Check-up? Check out Horizon Blue Cross Blue Shield of New Jersey’s Enhanced Website for a Dental Download of Helpful Information 2Health News:Send Word Now Announces Release of New User Interface for its Award-Winning Mass Notification Service 2Health News:Hiking Adds Benefits to Recovery at Serenity Palms 2Health News:Hiking Adds Benefits to Recovery at Serenity Palms 3Health News:NJ Top Doc, Dr. Gary Breslow, has launched Zwivel; a New Online Cosmetic Consultation Service for Doctors and Patients 2
... rank facilities don,t take all measurements into account , TUESDAY, ... onto the U.S. News & World Report list ... in some measurements regarding heart failure, researchers say. , "If ... the areas of heart failure mortality and readmission, you should ...
... be done up to 21 hours later with milder heart ... Many people who arrive at hospital emergency rooms with chest ... angioplasty, even if an electrocardiogram (EKG) shows evidence of a ... no significant difference in key measures of heart damage and ...
... 1 Zimmer Holdings, Inc. (NYSE: ZMH ; SWX: ZMH) announced ... of September: , , , Thomas ... 11:30 a.m. Eastern Time; , Morgan Stanley Healthcare Unplugged ... Eastern Time; and , UBS Global Life Sciences Conference ...
... , , , ... Hospital has earned the U.S. Environmental Protection Agency,s (EPA,s) prestigious ... environmental protection. St. Anthony,s is the first hospital in Florida ... achieve this recognition. Buildings that receive the EPA,s ENERGY STAR ...
... CHSI Solutions Hotline Provides NRSIG Members Immediate Medical Assessment -- ... September 1, 2009, employees of Nevada Restaurant Self-Insured Group members injured ... assessment from a medical professional when they call the CHSI Solutions ... Hotline will be available to NRSIG members and their employees all ...
... , , , ... an operating subsidiary of WellPoint, Inc. (NYSE: WLP ) and one ... on diagnostic imaging that appear in the August 27, 2009 issue of the ... article "Exposure to Low-Dose Ionizing Radiation from Medical Procedures" reviews the ...
Cached Medicine News:Health News:Government Best Source for U.S. Hospital Data, Study Finds 2Health News:Sometimes Angioplasty Can Wait 2Health News:St. Anthony's Hospital Is First to Earn EPA'S ENERGY STAR(R) Symbol for Superior Energy Efficiency 2Health News:St. Anthony's Hospital Is First to Earn EPA'S ENERGY STAR(R) Symbol for Superior Energy Efficiency 3Health News:Nevada Restaurant Self-Insured Group Launches 24-Hour Injury Hotline on September 1 to Ensure Employee Safety 2Health News:American Imaging Management Reacts to New England Journal of Medicine Articles on Diagnostic Imaging 2
Bone Curette, 160 mm...
Bone Currettes...
London Endocervical Curette is a stainless-steel curette for obtaining endocervical samples with minimal effort....
...
Medicine Products: