Navigation Links
Seattle Children's Invention Lands Major Funding with Hopes of Saving Thousands of Infant Lives Globally Each Year
Date:8/16/2011

SEATTLE, Aug. 16, 2011 /PRNewswire-USNewswire/ -- Seattle Children's Research Institute today announced the receipt of a two-year, $2.3 million grant from the Bill & Melinda Gates Foundation to complete prototype development of its new respiratory support device, called Seattle Children's Positive Airway Pressure (Sea-PAP.)  Sea-PAP, designed to be an affordable and simple Bubble Continuous Positive Airway Pressure (B-CPAP) device, will provide breathing support to premature infants who suffer from respiratory distress.  Upon completion, Sea-PAP will be significantly cheaper to produce, operate, and maintain than other ventilators and respiratory support devices.

Children's expects the affordability of Sea-PAP will lead to rapid adoption in the developing world and beyond.  The simple design shrinks the cost to a fraction of the $30,000 price tag for conventional ventilators, making Sea-PAP and its life-saving therapy accessible to healthcare systems that lack the resources to purchase and operate complex, expensive equipment.

"The worldwide need for low-cost, safe, and easy to use respirator technology is clear.  Many premature infants who require only basic assistance with their breathing die for a lack of a simple, affordable alternative to expensive ventilators," said Charles V. Smith, PhD, Director of the Center for Developmental Therapeutics at Seattle Children's Research Institute, and co-inventor of Sea-PAP.  "Sea-PAP's low cost and ease of use will make it accessible to all."

More than four million infants worldwide die each year, and one million of those deaths are attributed to respiratory insufficiency, suffocation due to underdeveloped lungs.  These deaths are largely attributed to the lack of respiratory support devices in resource-limited countries.  Children's estimates that Sea-PAP could save the lives of many thousands of these babies each year, if broadly adopted.

"Cost of technology should not be the deciding factor for which life is saved.  Sea-PAP will provide more communities, even in the most rural areas, with the tools to save premature infants with respiratory distress," said Thomas N. Hansen, MD, CEO at Children's and co-inventor of Sea-PAP.  "If we could even make a dent of a few percentage points in infant mortality rates, the impact would be staggering."

Preterm birth is the 7th leading U.S. healthcare expenditure today, costing approximately $26 billion a year.  A simple tool like Sea-PAP could also help address the financial burden that prematurity brings to healthcare.  

Benefits of Simplified Technology and Other Key Differentiators
What differentiates Sea-PAP from most other respiratory support devices is that it is simpler to assemble and maintain, thus enabling a low cost of ownership.  To build and operate Sea-PAP, only a small tool kit of supplies are needed, including a continuous air supply, a breathing circuit tube, a tube for the nose, water, and a competent human operator.  The breathing and nose tubes can be used multiple times, if sterilized.  

Sea-PAP works like conventional B-CPAP devices providing a continuous flow of air via tubes inserted in an infant's nostrils.  Sea-PAP's key differentiator from other B-CPAP devices is that its breathing circuit tube is placed in water at a 135 degree slope, which creates fluctuations in the positive airway pressure.  These fluctuations keep the lungs open, which lessens the work required from respiratory muscles, thus making it easier to breathe.  

Respiratory muscle exhaustion is a major cause of failure in conventional B-CPAP therapy.  These failures often necessitate the need for tracheal intubation, mechanical ventilation, and exposure of the infant to high concentrations of oxygen, which carry the risk of tissue damage, infection, and inflammation - all of which are major factors in the development of chronic lung disease.  By reducing the work that an infant has to do to breathe, Sea-PAP will eliminate the need for tracheal intubation and mechanical ventilation in many infants.

“Removing the cost barriers of life saving respiratory support technology ensures more infants have a chance at a healthy life,” said Gary Darmstadt, Director of Family Health at the Bill & Melinda Gates Foundation. “We are excited for the completion of Sea-PAP, as we believe it will have a significant impact on reducing infant mortality rates worldwide.”

Commercialization Timeline and Continued Development Plans
Children's expects to complete development of Sea-PAP in 2012, and for commercial distribution to begin in 2013.

Ongoing development will be led by Dr. Hansen, Dr. Smith, and C. Peter Richardson, PhD, (co-inventor), who have been working together on various respiratory care initiatives since the 1980s.  Other collaborators on the project include: Robert M. DiBlasi, RRT-NPS, FAARC (co-inventor); Kathleen D. Bongiovanni, MIPH, MS; Christopher R. Howard, MBA; Jack Hildebrandt, PhD; and John Walton.

Sea-PAP can also work in conjunction with the Hansen Ventilator, a separate respiratory device prototype the Children's team is developing, named after Dr. Hansen.  If used together, even more premature infants with respiratory distress could be saved.

“Sea-PAP by itself is the quickest and cheapest way we can save thousands of infants with respiratory distress,” said Dr. Hansen.  "If used in conjunction with the Hansen Ventilator, that number could increase substantially.  We hope to have the combined offering in market later in this decade."

The Hansen Ventilator is being developed by the same team working on Sea-PAP. More on the Hansen Ventilator can be found at: http://seattlechildrens.org/healthcare-professionals/aar/2010/highlights/high-hopes-for-low-tech-ventilator/

About Seattle Children's Research Institute
At the forefront of pediatric medical research, Seattle Children's Research Institute is setting new standards in pediatric care and finding new cures for childhood diseases. Internationally recognized scientists and physicians at the Research Institute are advancing new discoveries in cancer, genetics, immunology, pathology, infectious disease, injury prevention and bioethics. With Seattle Children's Hospital and Seattle Children's Hospital Foundation, the Research Institute brings together the best minds in pediatric research to provide patients with the best care possible. Children's serves as the primary teaching, clinical and research site for the Department of Pediatrics at the University of Washington School of Medicine, which consistently ranks as one of the best pediatric departments in the country. For more information, visit http://www.seattlechildrens.org/research.

CONTACT:
Kathy Porada
206-987-4500
press@seattlechildrens.org


'/>"/>
SOURCE Seattle Children's Hospital Research Institute
Copyright©2010 PR Newswire.
All rights reserved

Related medicine technology :

1. Swedish in Seattle to Study Connections Between Preeclampsia and Migraine
2. Seattles Swedish Cancer Institute First in U.S. to Treat Cancer Patient with Elekta VMAT
3. Dr. Seyed M. Rezaians Spinal Fixator a Revolutionary Invention for Healing Injuries of the Thoracolumbar Spine
4. Serious Eye Disease Gives Birth to Invention of Major New Eye Care Device
5. FAU Receives Patent for Invention Which Induces and Restores Cardiac Muscle Function
6. Diabetes Research Institute Invention Promotes Growth of Stem Cells into Insulin-Producing Cells
7. Disposable Hospital Supplies - Global Opportunity Assessment, Competitive Landscape and Market Forecasts to 2017
8. Global Diagnostic Imaging (CT, MRI, X-Ray & Ultrasound) Market - Competitive Landscape & Forecasts From 2010 to 2016
9. Significant Rise in Survival Rates for Elderly Lung Cancer Patients Treated Using Radiosurgery in Netherlands Detailed at World Conference for Lung Cancer
10. Gastrointestinal Endoscopes - Global Pipeline Analysis, Competitive Landscape and Market Forecasts to 2017
11. Hip Resurfacing Implants - Global Pipeline Analysis, Competitive Landscape and Market Forecasts to 2017
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/10/2017)... -- NDS received FDA 510(k) clearance in May 2017 for its highly ... designed for endoscopy environments. An innovative secondary monitor solution, ZeroWire ... support the improvement of patient outcomes, procedural efficiency, and the lowering ... ... ...
(Date:10/4/2017)... 4, 2017  South Korean-based healthcare product Development Company ... "cprCUBE" on Kickstarter. The device will educate the user ... with better efficiency compared to the dated and pricey ... on efficacy of the compression for a more informed ... goal to raise $5,000. ...
(Date:10/2/2017)... 2017  Eli Lilly and Company (NYSE: ... third quarter of 2017 on Tuesday, October 24, 2017. ... day with the investment community and media to further ... call will begin at 9 a.m. Eastern time. Investors, ... webcast of the conference call through a link that ...
Breaking Medicine Technology:
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... Apple ... care services, staged a mock evacuation of the facility as part of a disaster ... Fire Department, Echo Hose EMS and Shelton City Emergency Manager, as well as the ...
(Date:10/13/2017)... , ... October 13, 2017 , ... Global Healthcare Management’s ... Alexandria Park in Milford, NJ. This free event, sponsored by Global Healthcare Management’s ... The fun run is geared towards children of all ages; it is a ...
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the ... danger possible to save lost souls in the Philippines. “The Journey: From the Mountains ... a dedicated teacher of the Bible. She has taught all ages and currently teaches ...
(Date:10/12/2017)... ... October 12, 2017 , ... Planet Fitness, one of the largest and ... plans to open a flagship location in Covington, LA at 401 N. U.S. Highway ... store next to Office Depot in the Holiday Square shopping center. Its location allows ...
(Date:10/12/2017)... ... 2017 , ... Asante, a nationally recognized health system in ... existing home health joint venture through an agreement, effective October 1, 2017, to ... home health company with Asante, delivering clinically integrated care, for the past eight ...
Breaking Medicine News(10 mins):