Navigation Links
Seahorse Bioscience Announces the XF96 Extracellular Flux Analyzer for Cellular Bioenergetics
Date:10/6/2008

Novel technology opens the door to the understanding of and possible

treatments for obesity, diabetes, ageing and cancer

BILLERICA, Mass., Oct. 6 /PRNewswire/ -- Seahorse Bioscience today announced the release of the first ever analytical instrument for the kinetic measurement of mitochondrial oxygen consumption and cytoplasmic glycolysis in cells in a 96 well microplate. For the past 75 years tools for measuring cellular bioenergetics have been relatively unchanged since Warburg designed the Warburg Apparatus in 1932 and Leland Clark invented the Clark oxygen electrode in 1959.

"Without oxygen consumption measurements, the study of cellular bioenergetics would be in the dark ages," said David Nicholls, a leading bioenergetic researcher from Lund University, Sweden and the Buck Institute, Novato, CA. "Respiratory measurements allow us to quantify subtle changes in ATP turnover, mitochondrial uncoupling or respiratory chain inhibition that can immediately identify an interaction of a compound with the cell's energy generation pathways. Prior to the Seahorse, such studies were restricted to laborious single oxygen consumption measurements using the Clark electrode, invented in 1959, that required large amounts of material and was unsuitable for attached cells. The Seahorse requires just 2% of the material previously needed and has 100-fold the throughput! The ability to analyze cell (and therefore mitochondrial) respiration in a 96 well format and at the same time measure glycolytic flux will result in an immediate surge of scientific discoveries and new drugs. In particular it can lead to an early warning if a potential drug interacts with the cell's bioenergetic pathways."

Martin Brand, a leading mitochondrial researcher from the Buck Institute, Novato, CA and the MRC Dunn Human Nutrition Unit, Cambridge, UK comments, "I have been performing individual measurements of oxygen consumption and lactate production using cell suspensions for the greater part of my career and I trust Seahorse's XF technology, which allows us to make multiple simultaneous measurements of oxygen consumption and acid production using cells growing on culture plates," he said. "The XF format allows us to analyze the bioenergetics of cells under normal growth conditions with high throughput, greatly expanding our ability to investigate cellular bioenergetics."

"Seahorse provides a physiologically relevant assay for detecting the effect of RNAi knockdown of mitochondrial genes on cellular bioenergetics," added Vamsi Mootha, from the Broad Institute, MIT and Harvard's Massachusetts General Hospital. "This technology may accelerate the discovery of drugs for mitochondrial diseases."

The XF96 extracellular flux analyzer was developed to provide higher throughput analysis for customers desiring to study mitochondrial function and dysfunction, obesity, diabetes, cancer, ageing disorders, cardiac disease and drug toxicity.

"The first published Seahorse data was reported in a 2006 Nature article. We have been impressed with the breadth and number of new discoveries by the early users of our technology. In only two years, since the introduction of the first XF24 instrument, XF technology has become the new standard for measuring oxygen consumption and glycolysis by cells, replacing the 50 year old Clark Electrode," notes Jay Teich, CEO, Seahorse Bioscience. "And we are confident the XF96 will have a greater impact."

The new XF96 measures the two primary metabolic pathways in cells in minutes, using a label-free, non-destructive method. The easy to use instrument takes little lab space, does not disrupt stand cell culture procedures and provides measurement c.v.'s under 5%, approximately four times better than has been achievable using older technologies.

About Seahorse Bioscience, Inc. Seahorse XF instruments have become the new standard in cellular bioenergetic measurements. Over 200 plus scientists worldwide are advancing their research in understanding the role of cellular bioenergetics in obesity, diabetes, ageing, cancer, cardiovascular function and safety toxicity. Founded in 2001, Seahorse is headquartered in Billerica, MA.

Media Contact: Steve Chomicz

Phone: 978-671-1673


'/>"/>
SOURCE Seahorse Bioscience, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Related medicine technology :

1. ImmuneRegen BioSciences Reports Material Transfer Agreement with VaxGen, Inc.
2. ImmuneRegen BioSciences, Inc. Demonstrates Radilex(TM) Increases Disease-Fighting White Blood Cells
3. Upstream Biosciences Acquires Innovative Platform Technology and Drug Candidates for Tropical Parasitic Diseases
4. Ardea Biosciences, Inc. Announces Completion of Phase 1 Clinical Trials of Novel Investigational HIV Drug RDEA806
5. Ardea Biosciences, Inc. Presents Results of Phase 1 Studies of RDEA806, a Novel NNRTI for HIV, at 47th ICAAC
6. Ardea Biosciences Lead MEK Inhibitor, RDEA119, to Enter Human Clinical Trials in Advanced Cancer Patients
7. Alacrity Biosciences Announces Positive Results from a Phase 2 Study of Its Dry Eye Treatment ALTY-0501
8. Sangamo BioSciences and Sigma-Aldrich Announce Nature Biotechnology Study Demonstrating Zinc Finger Technology for Modification of Human Stem Cells
9. Regado Biosciences Initiates Phase IIa Clinical Study of REG1 Anticoagulation System
10. Regado Biosciences Presents Positive Data From REG1 Anticoagulation System Phase Ic Study at American Heart Association 2007 Scientific Sessions
11. Regado Biosciences Presents Early Stage Clinical Data for REG1 Anticoagulation System at American Heart Association 2007 Scientific Sessions
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... -- Research and Markets has announced the addition ... report to their offering. ... The World Market for Companion Diagnostics covers the world ... in the report includes the following: , ... by Region (N. America, EU, ROW), 2015-2020 , World ...
(Date:6/24/2016)... 2016   Pulmatrix, Inc ., (NASDAQ: ... drugs, announced today that it was added to the ... its comprehensive set of U.S. and global equity indexes ... important milestone for Pulmatrix," said Chief Executive Officer ... our progress in developing drugs for crucial unmet medical ...
(Date:6/24/2016)... KNOXVILLE, Tenn. , June 24, 2016 /PRNewswire/ ... market providing less invasive and more durable cerebrospinal ... million in funding.  The Series-A funding is led ... the Lighthouse Fund, and other private investors.  Arkis, ... less-invasive neurosurgical instrumentation and the market release of ...
Breaking Medicine Technology:
(Date:6/26/2016)... ... 26, 2016 , ... Pixel Film Studios Released ProSlice Levels, a Media Slicing ... their videos a whole new perspective by using the title layers in ProSlice ... , ProSlice Levels contains over 30 Different presets to choose from. FCPX ...
(Date:6/26/2016)... Lake Orion, Clarkston, Michigan (PRWEB) , ... June ... ... direction with respect to fertility once they have been diagnosed with endometriosis. These ... tolerable intercourse but they also require a comprehensive approach that can help for ...
(Date:6/25/2016)... ... ... The temporary closing of Bruton Memorial Library on June 21 due to a possible lice ... overlooked aspect of head lice: the parasite’s ability to live away from a human host, ... a necessary one in the event that lice have simply gotten out of control. , ...
(Date:6/25/2016)... CA (PRWEB) , ... June 25, 2016 , ... As ... with Magna Cum Laude and his M.D from the David Geffen School of Medicine ... and returned to Los Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive ...
(Date:6/25/2016)... Canada (PRWEB) , ... June 25, 2016 , ... Conventional ... pursuit of success. In terms of the latter, setting the bar too high can ... risk more than just slow progress toward their goal. , Research from ...
Breaking Medicine News(10 mins):