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Seahorse Bioscience Announces the XF96 Extracellular Flux Analyzer for Cellular Bioenergetics
Date:10/6/2008

Novel technology opens the door to the understanding of and possible

treatments for obesity, diabetes, ageing and cancer

BILLERICA, Mass., Oct. 6 /PRNewswire/ -- Seahorse Bioscience today announced the release of the first ever analytical instrument for the kinetic measurement of mitochondrial oxygen consumption and cytoplasmic glycolysis in cells in a 96 well microplate. For the past 75 years tools for measuring cellular bioenergetics have been relatively unchanged since Warburg designed the Warburg Apparatus in 1932 and Leland Clark invented the Clark oxygen electrode in 1959.

"Without oxygen consumption measurements, the study of cellular bioenergetics would be in the dark ages," said David Nicholls, a leading bioenergetic researcher from Lund University, Sweden and the Buck Institute, Novato, CA. "Respiratory measurements allow us to quantify subtle changes in ATP turnover, mitochondrial uncoupling or respiratory chain inhibition that can immediately identify an interaction of a compound with the cell's energy generation pathways. Prior to the Seahorse, such studies were restricted to laborious single oxygen consumption measurements using the Clark electrode, invented in 1959, that required large amounts of material and was unsuitable for attached cells. The Seahorse requires just 2% of the material previously needed and has 100-fold the throughput! The ability to analyze cell (and therefore mitochondrial) respiration in a 96 well format and at the same time measure glycolytic flux will result in an immediate surge of scientific discoveries and new drugs. In particular it can lead to an early warning if a potential drug interacts with the cell's bioenergetic pathways."

Martin Brand, a leading mitochondrial researcher from the Buck Institute, Novato, CA and the MRC Dunn Human Nutrition Unit, Cambridge, UK comments, "I have been performing individual measurements of oxygen consumption and lactate production using cell susp
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SOURCE Seahorse Bioscience, Inc.
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