Navigation Links
Seahorse Bioscience Announces the XF96 Extracellular Flux Analyzer for Cellular Bioenergetics

Novel technology opens the door to the understanding of and possible

treatments for obesity, diabetes, ageing and cancer

BILLERICA, Mass., Oct. 6 /PRNewswire/ -- Seahorse Bioscience today announced the release of the first ever analytical instrument for the kinetic measurement of mitochondrial oxygen consumption and cytoplasmic glycolysis in cells in a 96 well microplate. For the past 75 years tools for measuring cellular bioenergetics have been relatively unchanged since Warburg designed the Warburg Apparatus in 1932 and Leland Clark invented the Clark oxygen electrode in 1959.

"Without oxygen consumption measurements, the study of cellular bioenergetics would be in the dark ages," said David Nicholls, a leading bioenergetic researcher from Lund University, Sweden and the Buck Institute, Novato, CA. "Respiratory measurements allow us to quantify subtle changes in ATP turnover, mitochondrial uncoupling or respiratory chain inhibition that can immediately identify an interaction of a compound with the cell's energy generation pathways. Prior to the Seahorse, such studies were restricted to laborious single oxygen consumption measurements using the Clark electrode, invented in 1959, that required large amounts of material and was unsuitable for attached cells. The Seahorse requires just 2% of the material previously needed and has 100-fold the throughput! The ability to analyze cell (and therefore mitochondrial) respiration in a 96 well format and at the same time measure glycolytic flux will result in an immediate surge of scientific discoveries and new drugs. In particular it can lead to an early warning if a potential drug interacts with the cell's bioenergetic pathways."

Martin Brand, a leading mitochondrial researcher from the Buck Institute, Novato, CA and the MRC Dunn Human Nutrition Unit, Cambridge, UK comments, "I have been performing individual measurements of oxygen consumption and lactate production using cell suspensions for the greater part of my career and I trust Seahorse's XF technology, which allows us to make multiple simultaneous measurements of oxygen consumption and acid production using cells growing on culture plates," he said. "The XF format allows us to analyze the bioenergetics of cells under normal growth conditions with high throughput, greatly expanding our ability to investigate cellular bioenergetics."

"Seahorse provides a physiologically relevant assay for detecting the effect of RNAi knockdown of mitochondrial genes on cellular bioenergetics," added Vamsi Mootha, from the Broad Institute, MIT and Harvard's Massachusetts General Hospital. "This technology may accelerate the discovery of drugs for mitochondrial diseases."

The XF96 extracellular flux analyzer was developed to provide higher throughput analysis for customers desiring to study mitochondrial function and dysfunction, obesity, diabetes, cancer, ageing disorders, cardiac disease and drug toxicity.

"The first published Seahorse data was reported in a 2006 Nature article. We have been impressed with the breadth and number of new discoveries by the early users of our technology. In only two years, since the introduction of the first XF24 instrument, XF technology has become the new standard for measuring oxygen consumption and glycolysis by cells, replacing the 50 year old Clark Electrode," notes Jay Teich, CEO, Seahorse Bioscience. "And we are confident the XF96 will have a greater impact."

The new XF96 measures the two primary metabolic pathways in cells in minutes, using a label-free, non-destructive method. The easy to use instrument takes little lab space, does not disrupt stand cell culture procedures and provides measurement c.v.'s under 5%, approximately four times better than has been achievable using older technologies.

About Seahorse Bioscience, Inc. Seahorse XF instruments have become the new standard in cellular bioenergetic measurements. Over 200 plus scientists worldwide are advancing their research in understanding the role of cellular bioenergetics in obesity, diabetes, ageing, cancer, cardiovascular function and safety toxicity. Founded in 2001, Seahorse is headquartered in Billerica, MA.

Media Contact: Steve Chomicz

Phone: 978-671-1673

SOURCE Seahorse Bioscience, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Related medicine technology :

1. ImmuneRegen BioSciences Reports Material Transfer Agreement with VaxGen, Inc.
2. ImmuneRegen BioSciences, Inc. Demonstrates Radilex(TM) Increases Disease-Fighting White Blood Cells
3. Upstream Biosciences Acquires Innovative Platform Technology and Drug Candidates for Tropical Parasitic Diseases
4. Ardea Biosciences, Inc. Announces Completion of Phase 1 Clinical Trials of Novel Investigational HIV Drug RDEA806
5. Ardea Biosciences, Inc. Presents Results of Phase 1 Studies of RDEA806, a Novel NNRTI for HIV, at 47th ICAAC
6. Ardea Biosciences Lead MEK Inhibitor, RDEA119, to Enter Human Clinical Trials in Advanced Cancer Patients
7. Alacrity Biosciences Announces Positive Results from a Phase 2 Study of Its Dry Eye Treatment ALTY-0501
8. Sangamo BioSciences and Sigma-Aldrich Announce Nature Biotechnology Study Demonstrating Zinc Finger Technology for Modification of Human Stem Cells
9. Regado Biosciences Initiates Phase IIa Clinical Study of REG1 Anticoagulation System
10. Regado Biosciences Presents Positive Data From REG1 Anticoagulation System Phase Ic Study at American Heart Association 2007 Scientific Sessions
11. Regado Biosciences Presents Early Stage Clinical Data for REG1 Anticoagulation System at American Heart Association 2007 Scientific Sessions
Post Your Comments:
(Date:11/29/2015)... 29, 2015   Royal Philips  (NYSE: PHG, AEX: ... at the 2015 Radiological Society of North America Annual ... Place in Chicago . Visitors to ... company,s broad portfolio of integrated Diagnostic Imaging, Clinical Informatics, ... clinical performance, improve workflow and create a superior patient ...
(Date:11/29/2015)... Nov. 29, 2015   National Decision Support Company ... client base, including notable statewide implementations. As a ... solution, ACR Select, more than 1 million times ... workflow. ACR Select provides real-time feedback on the ... and has been implemented at over 100 healthcare ...
(Date:11/27/2015)... PHILADELPHIA , Nov. 27, 2015  Lannett ... that it has completed the acquisition of Kremers ... pharmaceuticals subsidiary of global biopharmaceuticals company UCB S.A. ... --> Lannett has acquired KU from UCB ... to certain adjustments, including a customary working capital ...
Breaking Medicine Technology:
(Date:11/30/2015)... ... November 30, 2015 , ... Sikka Software announced today ... Meeting. Their Ecosystem empowers dentists to make complex business decisions by providing the tools ... receive a free fee survey with 10 procedures customized by zip code. , ...
(Date:11/30/2015)... ... 30, 2015 , ... Scott Newman MD, FACS of New ... plastic surgeons in the New York City area to utilize the new, non-invasive ... heat-induced laser treatment for fat loss in the abdomen, flanks, and other areas ...
(Date:11/30/2015)... Atlanta, Georgia (PRWEB) , ... November 30, 2015 ... ... training for healthcare professionals worldwide today released the results of a survey of ... Middle East and Africa found a growing global demand for high quality online ...
(Date:11/30/2015)... Miami, FL (PRWEB) , ... November 30, 2015 ... ... manufacturer and engineer of patented products, announces the Unstoppable Swappables, a household invention ... Window Coverings Industry makes $2 billion a year and is growing at 2.6%," ...
(Date:11/29/2015)... Michigan (PRWEB) , ... November 29, 2015 , ... "I ... games. Things that as a Mother and Wife would love to do, I missed. ... that I just happened to call Dr. Zaidan first. They have changed my life ...
Breaking Medicine News(10 mins):