Navigation Links
Scientists Unmask Genetic Markers Associated With Psoriasis
Date:1/25/2009

University of Michigan scientists reveal DNA 'hotspots' linked to psoriasis

ANN ARBOR, Mich., Jan. 25 /PRNewswire-USNewswire/ -- Scientists at the University of Michigan Department of Dermatology, the U-M School of Public Health and their collaborators have found DNA "hotspots" that may reveal how genetic differences among individuals result in psoriasis, an autoimmune disease of the skin. Published in Nature Genetics, the findings could lead to new drug targets and tailored treatments for the disease.

"This discovery highlights the role of several genes in mediating the immune responses that result in psoriasis," says Goncalo Abecasis, Ph.D., co-principal investigator on the project, and associate professor of biostatistics in the School of Public Health. "Some of the highlighted genes, like those in the IL-23 pathway are already targeted by effective psoriasis therapies. Others, like TNFAIP3 and TNIP1, may become targets for the psoriasis treatments of the future."

Psoriasis affects some 7.5 million people in the United States, causing sore, itchy patches of red, scaly skin. In many cases psoriasis is not only disfiguring; between 10 and 30 percent of patients develop psoriatic arthritis, a painful inflammation of the joints. Current treatments, including different types of immunosuppressive agents, aren't always effective, and they can cause serious side effects.

Psoriasis has a strong genetic component; a child with two affected parents has a 50 percent chance of developing it; siblings have a three- to six-fold risk. But the genes responsible for psoriasis haven't yet been completely understood.

In this large, multi-center study, researchers used cutting-edge ge
'/>"/>

SOURCE University of Michigan Health System
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. 42 Top U.S. Scientists and Specialists Explore Cutting-Edge Innovations to Defend America From Dangerous Zoonotic Diseases
2. Gene Found Activated in 70% of Prostate Cancer Cases, George Washington University Medical Center Scientists Report
3. Battelle Scientists Named on Patent for Making Oxygen From Light and Water
4. Scientists Reveal Roadmap to Brain Health That Can Be Passed Down to Future Generations: Exercise, Omega-3, Folic Acid, Vitamin B6, and Vitamin B12
5. Tengion Scientists Publish Key Preclinical Findings Demonstrating the Benefits of Organ Regeneration Vs. Repair
6. Brain Stem Cells Can Be Awakened, Say Schepens Scientists
7. Infant Vaccines Produce Autism Symptoms in New Primate Study by University of Pittsburgh Scientists
8. ImQuest Scientists Present Important HIV Microbicide Development Results at Microbicides 2008 in Delhi, India
9. Neuroscientists Offer Hope for Breast Cancer Patients Suffering From Chemobrain
10. A Milestone in Cancer Genetics: deCODE Discovers First Common Genetic Variants Affecting the Risk of Many Types of Cancer
11. Landmark Research Study is Launched to Assess Impact of Personal Genetic Testing
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/2/2015)... Calif. , March 2, 2015  Kush ... supplier of child-resistant packaging solutions for the marijuana ... Nicholas Kovacevich , has been nominated for a ... The Excellence in Entrepreneurship Award is designed to ... – individuals who, by their creativity and determination, ...
(Date:3/2/2015)... 2, 2015  Maquet Medical Systems ... signed an exclusive distribution agreement with Flight Medical ... the Flight 60 mechanical ventilator. The Flight 60 ... and affordable mobility. Starting in the first quarter ... in the United States ...
(Date:3/2/2015)... , March 2, 2015 ... the population with nearly 38,000 of those ... Staphylococcus Aureus), a highly contagious disease, infects ... deaths.  Each of these and more, not ... through casual contact with other infectious individuals, ...
Breaking Medicine Technology:Kush Bottles CEO, Nicholas Kovacevich, Nominated for 2015 "Excellence in Entrepreneurship Award" 2Maquet Medical Systems USA to Exclusively Distribute Flight Medical's Flight 60 Respiratory Ventilators 2Maquet Medical Systems USA to Exclusively Distribute Flight Medical's Flight 60 Respiratory Ventilators 3Cleanint Rolls Out Cleanstethoscope and Cleanhands to Largest Medical Transportation Company in the Nation 2Cleanint Rolls Out Cleanstethoscope and Cleanhands to Largest Medical Transportation Company in the Nation 3
(Date:3/2/2015)... York, NY (PRWEB) March 02, 2015 ... Drug Administration (FDA) warned against the use of ... hysterectomies and fibroid removal surgeries, insurer UnitedHealthCare is ... the use of those devices. In a notification ... that beginning in April, it would require pre-authorization ...
(Date:3/2/2015)... March 02, 2015 ZoomCare announced ... remake American healthcare. Zoom will expand its Portland ... clinics and advanced care studios delivering urgent care, ... services, specialty care and outpatient surgery. With its ... to almost all healthcare needs outside of hospitalization. ...
(Date:3/2/2015)... New York (PRWEB) March 02, 2015 ... Recovery at Recovery Unplugged™—will be delivering a plenary ... Singer/Songwriter's Perspective on the Art of Healing and ... Disorders (NCAD) and Behavioral Healthcare Executive Summit (BHES).     ... name, Mr. Supa’s songs have been recorded by ...
(Date:3/2/2015)... NY (PRWEB) March 02, 2015 This year, ... March 2–8 and will provide opportunities for people across the ... ways to help people with MS live their best lives. ... made and to inspire others to join the Society’s vision ... sclerosis, an unpredictable, often disabling disease of the central nervous ...
(Date:3/2/2015)... 2015 Regulatory Compliance Associates® Inc. ... regulatory and technical consulting, announces Mr. Seyed Khorashahi ... , Before joining RCA, Mr. Khorashahi had ... in all aspects of developing safety-critical medical devices. ... (Medtronic), Regulatory Compliance Associates Inc., Baxter Healthcare, and ...
Breaking Medicine News(10 mins):Health News:Power Morcellator Lawyers at Bernstein Liebhard LLP Comment on Insurers’ Decision to Restrict Most Common Form of Hysterectomies 2Health News:Power Morcellator Lawyers at Bernstein Liebhard LLP Comment on Insurers’ Decision to Restrict Most Common Form of Hysterectomies 3Health News:Power Morcellator Lawyers at Bernstein Liebhard LLP Comment on Insurers’ Decision to Restrict Most Common Form of Hysterectomies 4Health News:ZoomCare Announces 28-Location, On-Demand Neighborhood Health Campus 2Health News:ZoomCare Announces 28-Location, On-Demand Neighborhood Health Campus 3Health News:Richie Supa Announced as a Plenary Speaker at NCAD 2015 2Health News:Every Connection Counts During MS Awareness Week 2Health News:Every Connection Counts During MS Awareness Week 3Health News:Every Connection Counts During MS Awareness Week 4Health News:Regulatory Compliance Associates® Inc. Welcomes Seyed Khorashahi as Chief Operating Officer 2
... which expands into Optical Coherence Tomography. This breakthrough has made ... angioplasty. This has been developed by Dr. Brett Bouma an ... coherence tomography to gauge stent status.// , ... to ultrasound and will allow cardiologists to view the status ...
... wounds and wound healing has always been difficult terrain for ... processes and understanding inter cellular mechanisms is the key to ... Researchers led by Vito Quaranta at ... integrin-a protein that helps trigger the healing process -- also ...
... parathyroid hormone (parathormone) increases the patient’s bone density and cut the ... in regulating calcium levels in the body. , ... fractures has opened up the prospect of the hormone being used ... known as.// , The ...
... discovered in plants, has been pin pointed in humans as being ... The chances of developing an inherited form of the diseases increases ... on chromosome 16. , ... and USA. The complete data will appear in the May 31st ...
... 24th issue of Nature reveals that the Obesity Hormone – ... more complex way than previously believed. This break through has ... and many nutrition related disorders like anorexia nervosa. Dr. Malcolm ... the study. , ...
... Clinic created a break through in ENT surgery by conducting ... recipient of the transplant is not able to speak with ... the motorcycle accident. He had been unable to speak normally ... speeches to other patients and support groups. , ...
Cached Medicine News:
Shandon Microscope Slide Trays...
... is the first solid-state,photocoagulator to ... wavelengths. This advanced,laser system makes ... a red or green wavelength,during ... and ensures effective,patient results., For ...
... Gathering, managing, and transmitting data ... you were hired for. Dawnings ResultNet/Plus ... running your lab, not your communications ... with transmitting result data from largescale ...
... Horizon Cardiology Hemo is a comprehensive ... for the cath lab. Patient ... cardiac images and procedural information all ... patient record, eliminating repetitive data entry. ...
Medicine Products: