Navigation Links
Scientists Unmask Genetic Markers Associated With Psoriasis
Date:1/25/2009

University of Michigan scientists reveal DNA 'hotspots' linked to psoriasis

ANN ARBOR, Mich., Jan. 25 /PRNewswire-USNewswire/ -- Scientists at the University of Michigan Department of Dermatology, the U-M School of Public Health and their collaborators have found DNA "hotspots" that may reveal how genetic differences among individuals result in psoriasis, an autoimmune disease of the skin. Published in Nature Genetics, the findings could lead to new drug targets and tailored treatments for the disease.

"This discovery highlights the role of several genes in mediating the immune responses that result in psoriasis," says Goncalo Abecasis, Ph.D., co-principal investigator on the project, and associate professor of biostatistics in the School of Public Health. "Some of the highlighted genes, like those in the IL-23 pathway are already targeted by effective psoriasis therapies. Others, like TNFAIP3 and TNIP1, may become targets for the psoriasis treatments of the future."

Psoriasis affects some 7.5 million people in the United States, causing sore, itchy patches of red, scaly skin. In many cases psoriasis is not only disfiguring; between 10 and 30 percent of patients develop psoriatic arthritis, a painful inflammation of the joints. Current treatments, including different types of immunosuppressive agents, aren't always effective, and they can cause serious side effects.

Psoriasis has a strong genetic component; a child with two affected parents has a 50 percent chance of developing it; siblings have a three- to six-fold risk. But the genes responsible for psoriasis haven't yet been completely understood.

In this large, multi-center study, researchers used cutting-edge ge
'/>"/>

SOURCE University of Michigan Health System
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. 42 Top U.S. Scientists and Specialists Explore Cutting-Edge Innovations to Defend America From Dangerous Zoonotic Diseases
2. Gene Found Activated in 70% of Prostate Cancer Cases, George Washington University Medical Center Scientists Report
3. Battelle Scientists Named on Patent for Making Oxygen From Light and Water
4. Scientists Reveal Roadmap to Brain Health That Can Be Passed Down to Future Generations: Exercise, Omega-3, Folic Acid, Vitamin B6, and Vitamin B12
5. Tengion Scientists Publish Key Preclinical Findings Demonstrating the Benefits of Organ Regeneration Vs. Repair
6. Brain Stem Cells Can Be Awakened, Say Schepens Scientists
7. Infant Vaccines Produce Autism Symptoms in New Primate Study by University of Pittsburgh Scientists
8. ImQuest Scientists Present Important HIV Microbicide Development Results at Microbicides 2008 in Delhi, India
9. Neuroscientists Offer Hope for Breast Cancer Patients Suffering From Chemobrain
10. A Milestone in Cancer Genetics: deCODE Discovers First Common Genetic Variants Affecting the Risk of Many Types of Cancer
11. Landmark Research Study is Launched to Assess Impact of Personal Genetic Testing
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/1/2015)... -- According to a new market research ... (Calcium Phosphate, Lipofection, Dendrimers), Physical (Electroporation, Nucleofection), Viral), by ... to 2020", published by MarketsandMarkets, the Transfection Reagents and ... by 2020 with a CAGR of 7.2% from 2014 ... ables and 33 F igures ...
(Date:7/1/2015)... -- Research and Markets( http://www.researchandmarkets.com/research/nk3569/future_horizons ... "Future Horizons and Growth Strategies in the European ... Forecasts" report to their offering. ... Blood Banking Market 2015 is a new five-countrystrategic ... and potential market entrants identify and evaluate emerging ...
(Date:7/1/2015)... MARLBOROUGH, Mass. , July 1, 2015 Boston ... call discussing financial results and business highlights for the second ... at 8 a.m. ET. The call will be ... officer, and Dan Brennan , executive vice president and ... conference call will be available via the Boston Scientific website. ...
Breaking Medicine Technology:Transfection Reagents and Equipment Market Worth $957.9 Million by 2020 2Transfection Reagents and Equipment Market Worth $957.9 Million by 2020 3Transfection Reagents and Equipment Market Worth $957.9 Million by 2020 4European Blood Banking 2015: Future Horizons and Growth Strategies - Supplier Shares and Country Forecasts 2European Blood Banking 2015: Future Horizons and Growth Strategies - Supplier Shares and Country Forecasts 3Boston Scientific To Webcast Second Quarter 2015 Earnings Call On July 23 2
... TechniScan (OTC Bulletin Board: TSNI ), a ... an automated 3D breast ultrasound imaging system, announced today that ... with Austin, Texas-based Womens3D. These agreements follow ... January 2011 in which they agreed to jointly develop a ...
... PDL BioPharma, Inc. (PDL) (Nasdaq: PDLI ... company,s president and chief executive officer, is scheduled ... Markets Healthcare ConferenceWednesday, March 2, 20119:00 a.m. Eastern ... Health Care Conference Tuesday, March 8, 201111:00 a.m. ...
Cached Medicine Technology:Breast Imaging Company, TechniScan, Signs Manufacturing Agreement With Texas Company 2
(Date:7/1/2015)... ... 01, 2015 , ... After conducting a nationwide executive ... Medical Center in Oceanside, Calif., has hired Cheryle Bernard-Shaw as chief compliance ... adaptation efforts and growing a focus on risk management, Bernard-Shaw will assume her ...
(Date:7/1/2015)... ... ... Incentivizing the use of generic drugs has been an easy way for plans ... off the prices for the brand-name products. But now that generics are experiencing record ... these high-cost generic drugs. The July issue of Atlantic Information Services, Inc.’s (AIS) The ...
(Date:7/1/2015)... ... 01, 2015 , ... Northbound Treatment Services announced today that ... , Emily originally entered the behavioral healthcare industry as an academic director ... curriculum for clients to engage in their educational journey while in treatment. In ...
(Date:7/1/2015)... ... ... Thule Atmos X4 offers protection with minimal bulk. At the Thule Test Center™, ... Due to its Bi-ComponentArmor and ShockStop corners, it passed Thule’s 2 meter drop test, ... The Thule Atmos X4 has also been designed with function in mind. The ...
(Date:7/1/2015)... Raton, FL (PRWEB) , ... July 01, 2015 , ... ... wide range of nutritional and beauty products, recently attended the 2015 ECRM Diet, Vitamin ... big-time connections in the retail industry. The ECRM trade show allows companies ...
Breaking Medicine News(10 mins):Health News:Tri-City Medical Center Hires New Chief Compliance Officer 2Health News:Tri-City Medical Center Hires New Chief Compliance Officer 3Health News:Blues Execs Share Strategies for Managing Generic Drug Inflation in AIS Newsletter 2Health News:Blues Execs Share Strategies for Managing Generic Drug Inflation in AIS Newsletter 3Health News:Northbound Treatment Services Welcomes Emily Orrick as Director of Referral Relations 2Health News:NPI Meets With Top Retail Figures at ECRM Conference 2
... , THURSDAY, Sept. 15 (HealthDay News) -- Children typically don,t die ... Thursday that 115 kids younger than 18 died from flu-related causes ... many of the deaths could have been prevented if the children ... U.S. Centers for Disease Control and Prevention. , , ...
... protein linked to cell division and migration and tied to ... high levels in breast cancer specimens and cell lines. The ... in breast cancer cells than in normal breast cells. ... findings and others in a paper now online in the ...
... News) -- Experts around the world have issued a call ... A group of international medical bodies said physicians can ... and it also urged governments to take action and address ... in preventable and premature disease, affecting 76 million people globally. ...
... Clinic have received a grant from the National Institutes of ... test that conclusively identifies concussions in college football players. ... after a game searches for a biomarker known as ... in an athlete,s blood. Damir Janigro, Ph.D., and Nicola ...
... -- Not enough children and teens drink low-fat milk, a ... Prevention reveals. Drinking milk is important for children,s bone ... the calcium, vitamin D and other nutrients found in milk, ... milk products to avoid unnecessary fat and calories. ...
... In order to better prevent blood clots, the drugs ... acute ischaemia of the heart muscle, in addition to ... Efficiency in Health Care (IQWiG) has now investigated whether, ... coronary intervention (PCI), the combination of prasugrel plus ASA ...
Cached Medicine News:Health News:Flu Killed 115 Children Last Season: CDC 2Health News:Flu Killed 115 Children Last Season: CDC 3Health News:Study finds protein critical to breast cancer cell proliferation, migration 2Health News:Doctors Urged to Lead Battle Against Alcohol Abuse 2Health News:Cleveland Clinic researchers awarded NIH grant to study concussion-identifying blood test 2Health News:Cleveland Clinic researchers awarded NIH grant to study concussion-identifying blood test 3Health News:Not Enough Kids Drink Low-Fat Milk, U.S. Study Finds 2Health News:Prasugrel: Indications of an additional benefit for some patients, but also of greater harm 2Health News:Prasugrel: Indications of an additional benefit for some patients, but also of greater harm 3Health News:Prasugrel: Indications of an additional benefit for some patients, but also of greater harm 4
For the qualitative detection of IgG/IgM antibodies to B. burgdorferi...
... surgical-quality loupes available at manufacturer-direct ... innovative optical design, combining superior quality ... with maximum comfort, SheerVision loupes are ... worldwide. Make both a professional and ...
... surgical-quality loupes available at manufacturer-direct ... innovative optical design, combining superior quality ... with maximum comfort, SheerVision loupes are ... worldwide. Make both a professional and ...
... the first manufacturer to offer through-the-lens ... wearer. These next generation loupes feature ... ultra-lightweight design, and are multi-coated lens ... With SheerVision's proprietary SureFit system - ...
Medicine Products: