Navigation Links
Scientists Identify Gene for Short Circuiting Excess Mucous in Lung Disease, Common Colds
Date:9/14/2009

Whitsett and his colleagues also found the metaplasia process in this instance to be reversible. Goblet cells can change back to Clara cells if the detrimental genetic influence is blocked, highlighting a possible pathway for new treatments, according to Dr. Whitsett, who also is executive director of the Perinatal Institute at Cincinnati Children's.

The study identifies a transcription factor, SPDEF, as the master gene that regulates a chain of dozens of downstream genes involved in mucous production. SPDEF is an active player in other organ systems that need to produce mucous for normal function, such as the digestive system. In healthy lungs, however, the researchers report the gene is mostly quiet, as healthy lungs don't produce significant amounts of mucous.

Using an egg white protein called ovalbumin to induce an allergic reaction and inflammation in the lungs of mice, the researchers observed a dramatic elevation in the expression of SPDEF in the lung tissues of the affected animals. The animals also experienced hyper-production of thick mucous in their lungs. In mice where the SPDEF gene was switched off, inflammation and excessive mucous production did not occur, demonstrating the gene's potential as therapeutic or diagnostic target. Mice lacking SPDEF were unable to increase mucous production or develop goblet cells.

In mice where respiratory inflammation and excessive mucous production were present, the researchers report that SPDEF turned off genes involved in biological processes that help protect lung tissues from infection and damage. Conversely, SPDEF activated genes that promote inflammation and excessive mucous - in particular FOXA3, AGR2 and mucins.

By composition, mucous is a sugar-coated collection of large proteins that, in healthy conditions, help the body defend itself by collecting and then clearing out contaminants. In the case of AGR2 for example, the gene helps
'/>"/>

SOURCE Cincinnati Children's Hospital Medical Center
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. IBM Scientists First to Image the Anatomy of a Molecule
2. Scientists Discover Origin of Malaria
3. International Journal of Occupational and Environmental Health Features Discovery of Asbestos-Related Pain Origin from Scientists at the Karmanos Cancer Institute in Detroit
4. Scientists at The Karmanos Cancer Institute in Detroit Identify Potential New Target for Breast Cancer Therapy
5. Scientists Discover a Role for the Growth Factor TGF-beta in Maintaining Health of Retinal Blood Vessels
6. Scientists Discover Why Teeth Form in a Single Row
7. Scientists Unmask Genetic Markers Associated With Psoriasis
8. 42 Top U.S. Scientists and Specialists Explore Cutting-Edge Innovations to Defend America From Dangerous Zoonotic Diseases
9. Gene Found Activated in 70% of Prostate Cancer Cases, George Washington University Medical Center Scientists Report
10. Battelle Scientists Named on Patent for Making Oxygen From Light and Water
11. Scientists Reveal Roadmap to Brain Health That Can Be Passed Down to Future Generations: Exercise, Omega-3, Folic Acid, Vitamin B6, and Vitamin B12
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/27/2015)... NAMUR , Belgium , July ... MKT: VNRX), a life sciences company focused on developing ... types and other conditions, today announced that it has ... research organization, Global Specimen Solutions, Inc. (GSS), to support ... colorectal cancer tests. Under the agreement, ...
(Date:7/27/2015)... DUBLIN , July 27, 2015 Research ... of the "Intraoperative Imaging Market by Type (Intraoperative ... America, Europe, Asia-Pacific, ROW) - Global Forecast to 2019" ... market is expected to reach a value of $2.1 ... a CAGR of 3.5% during the forecast period. ...
(Date:7/27/2015)... 2015   Iagnosis , the creator of ... online dermatology solutions, announced today its 2015 year-to-date ... has contractual relationships with dermatologists in 30 states, ... Dermatologists and Extenders Since December 2014, the ... of providers delivering care through the platform, which ...
Breaking Medicine Technology:VolitionRx Engages Specialty Clinical Research Organization to Support Initial Entry of its NuQ(R) Colorectal Cancer Tests via U.S. CLIA Labs 2VolitionRx Engages Specialty Clinical Research Organization to Support Initial Entry of its NuQ(R) Colorectal Cancer Tests via U.S. CLIA Labs 3VolitionRx Engages Specialty Clinical Research Organization to Support Initial Entry of its NuQ(R) Colorectal Cancer Tests via U.S. CLIA Labs 4VolitionRx Engages Specialty Clinical Research Organization to Support Initial Entry of its NuQ(R) Colorectal Cancer Tests via U.S. CLIA Labs 5VolitionRx Engages Specialty Clinical Research Organization to Support Initial Entry of its NuQ(R) Colorectal Cancer Tests via U.S. CLIA Labs 6VolitionRx Engages Specialty Clinical Research Organization to Support Initial Entry of its NuQ(R) Colorectal Cancer Tests via U.S. CLIA Labs 7Global Intraoperative Imaging (Intraoperative CT, Intraoperative MRI, Intraoperative Ultrasound) Market Forecasts & Trends 2015-2019 2Iagnosis Reports Significant Growth YTD 2015 2
... Jan. 13, 2011 Baylor Health Care System is ... quality of patient care in North Texas through the ... health care system.  It is one of thousands of ... with the U.S. Department of Health and Human Services ...
... 13, 2011 Dendreon Corporation (Nasdaq: DNDN ) ... other conditions, $500 million aggregate principal amount of convertible senior ... registered under the Securities Act of 1933, as amended (the ... of Dendreon,s common stock (the "Common Stock") or a combination ...
Cached Medicine Technology:Baylor Health Care System Registers its Commitment to Achieve Meaningful Use of the Electronic Health Record 2Dendreon Announces Offering of $500 Million Convertible Senior Notes Due 2016 2Dendreon Announces Offering of $500 Million Convertible Senior Notes Due 2016 3Dendreon Announces Offering of $500 Million Convertible Senior Notes Due 2016 4
(Date:7/27/2015)... , ... July 27, 2015 , ... With a new ... with PursuitSAFETY to support its mission of reducing the number of deaths and injuries ... support victims and their families. PursuitSAFETY works with the police to find better ...
(Date:7/27/2015)... , ... July 27, 2015 , ... For a limited ... promotion on Zoom teeth whitening. Summer is a great time to change up a ... reasons, but discolored teeth can really affect your self-esteem. Over time, the enamel coating ...
(Date:7/27/2015)... , ... July 27, 2015 , ... ... fullerenes in medical and diagnostics applications is rapidly increasing and is driven by ... cancer treatment, they are increasingly being evaluated for use in bio implants. MWCNTs ...
(Date:7/27/2015)... ... 27, 2015 , ... The Advocator Group, LLC, a nationwide ... Cogswell as the vice president of client services. Mr. Cogswell has over twenty ... role in the growth and transformation of several businesses, including Bob’s Discount Furniture ...
(Date:7/27/2015)... ... 27, 2015 , ... Premier Insurance Advisors, a full service ... charity and awareness event with the Houston chapter of NAMI, the National Alliance ... to bettering the lives of the millions of Americans affected by mental illness. ...
Breaking Medicine News(10 mins):Health News:Gary Short & Associates in Chico, CA Initiates Charity Campaign to Collaborate with National Nonprofit PursuitSAFETY 2Health News:Gary Short & Associates in Chico, CA Initiates Charity Campaign to Collaborate with National Nonprofit PursuitSAFETY 3Health News:Huntington Beach Cosmetic Dentist, Dr. Rassouli, is Now Offering a Summer Promotion on Zoom Whitening 2Health News:Huntington Beach Cosmetic Dentist, Dr. Rassouli, is Now Offering a Summer Promotion on Zoom Whitening 3Health News:Fullerene Market to Grow at 13% CAGR to 2019 Says a New Research Report at Sandlerresearch.org 2Health News:Fullerene Market to Grow at 13% CAGR to 2019 Says a New Research Report at Sandlerresearch.org 3Health News:The Advocator Group, LLC Announces Jonathan Cogswell as Vice President of Client Services 2Health News:The Advocator Group, LLC Announces Jonathan Cogswell as Vice President of Client Services 3Health News:Premier Insurance and the National Alliance of Mental Health Launch Grassroots Charity Effort to Support Houston Residents with Developmental Challenges 2Health News:Premier Insurance and the National Alliance of Mental Health Launch Grassroots Charity Effort to Support Houston Residents with Developmental Challenges 3
... from NIDCR have created an animal model that ... II and dentin dysplasia. Dr. Ashok Kulkarni and ... amounts of TGF-b1 (transforming growth factor beta-1) in ... apparent defects, but at two weeks their teeth ...
... researchers people who sleep for more or less than seven ... over one million adults conducted over a six year time ... hours sleep a night might need modifying. Looking at the ... expectancy, researchers at the University of Texas, and colleagues, find ...
... an exclusively Western problem. Researchers say weight problems ... in developing nations, particularly children. Until recently, famine ... to the health of poor people in developing ... processing and even leisure time in developing countries ...
... kidney cancer in the UK has risen by 68 per cent ... a year. Research in UK says that 5,700 people each year ... lowest in Europe.// The disease accounts for an estimated 95,000 worldwide ... ,According to Dr Nick James, a consultant at the Queen Elizabeth ...
... conduct tests for any Indian doctor having graduated abroad avid ... higher standards amongst doctors, the government has made it compulsory ... today. , The new regulations, ... students who want to enrol in MBBS course abroad will ...
... men tend to die younger than married ones. Psychiatrists ... health by giving them emotional ward.// ,Researchers in ... heart disease and stroke were higher in unmarried men ... in death rates between married and unmarried women. ...
Cached Medicine News:Health News:Heriditary dental disorders 2
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: