Navigation Links
Scientists Discover Origin of Malaria
Date:8/3/2009

Discovery Could Lead to Development of New Treatments, Prevent Future Plagues

SAN FRANCISCO, Aug. 3 /PRNewswire-USNewswire/ -- Today scientists reported that they have discovered the origin of malaria, one of the deadliest diseases of humanity. Chimpanzees, native to equatorial Africa, have been identified as the original source of the parasite that likely moved from them to humans via mosquitoes.

An international group of researchers, including senior author Nathan Wolfe, Ph.D., of the Global Viral Forecasting Initiative and Stanford University, made the discovery, published in the Aug. 3 2009 Proceedings of the National Academy of Sciences, by identifying several new parasites from chimpanzees. The newly discovered parasites show that malaria jumped from animals to humans, much the way that HIV, SARS and swine flu originated.

"This discovery shows that ancient diseases, such as malaria, can originate in the same way that modern pandemics do, namely by jumping from animals to humans" Wolfe said. "We now know that malaria, while at least thousands of years old, did not originate in humans but rather was introduced into our species, presumably by the bite of a mosquito that had previously fed on a chimpanzee."

Until now, malaria's origin had been unclear. Although chimpanzees were known to harbor a parasite, called Plasmodium reichenowi, that is closely related to the dominant human malaria parasite, Plasmodium falciparum, most scientists assumed incorrectly that these parasites had co-existed separately in human and chimpanzee ancestors for the last 5 million years.

The newly discovered parasites not only demonstrate how malaria originated, but represent potentially powerful tools for developing vaccines and treatments against this deadly scourge. Discovery of these parasites indicates that there is a much broader range of close relatives to the human parasite than were previously recognized, some of which might provide key insights in drug development or act as vaccines that could prevent human malaria.

"Dr. Wolfe's discovery of the origin of human malaria is a perfect example of the kind of research supported by the NIH Director's Pioneer Award program, which gives outstanding investigators a chance to test exceptionally innovative and potentially paradigm-shifting ideas," said Raynard S. Kington, M.D., Ph.D., acting director of the National Institutes of Health.

Wolfe and his colleagues sampled wild and wild-born captive chimpanzees in Cameroon and Ivory Coast. In Cameroon researchers collected samples from chimpanzees during routine health exams in three different wildlife sanctuaries. They were primarily wild-born animals brought to the sanctuaries after being confiscated by authorities or abandoned by human owners. In Ivory Coast scientists from the Robert Koch Institute and Max Planck Institute for Evolutionary Anthropology collected tissue and blood samples from 10 chimps that had died due to anthrax, respiratory disease or other reasons in the Tai National Park. Samples were analyzed in the laboratory of Stephen Rich, Ph.D., at the University of Massachusetts, Amherst.

"It is now clear that a new disease that successfully jumps from an animal to a human can last not just for decades, but millennia or more," Wolfe said. "This makes the task of stopping future disease spillovers from animals to humans vital, not only for saving lives today, but for the health of people for many generations to come."

Every year malaria:

  • Accounts for 500 million cases per year.
  • Results in more than one million deaths -- mostly children.
  • Includes 1,300 cases in the United States.
  • Cuts economic growth by as much as 1.3 percent in countries with high disease rates.
  • Occurs primarily in tropical and subtropical regions such as Central and South America, Southeast Asia, sub-Saharan Africa, the Caribbean and the South Pacific Islands.

The Global Viral Forecasting Initiative has spent the last ten years developing a global system to prevent pandemics. By coupling innovative surveillance in field sites throughout the world with a consortium of top laboratories, GVFI is able to characterize the diversity of viruses and other agents as they move from animals to humans. GVFI virus hunter Nathan Wolfe, Ph.D., has studied how this happens -- and how frequently it happens -- and has identified a number of new infectious diseases. The group's work provides basic insights into how pandemics are born and employs cutting-edge strategies to prevent the next major pandemic.


'/>"/>
SOURCE Global Viral Forecasting Initiative
Copyright©2009 PR Newswire.
All rights reserved

Related medicine technology :

1. International Journal of Occupational and Environmental Health Features Discovery of Asbestos-Related Pain Origin from Scientists at the Karmanos Cancer Institute in Detroit
2. Scientists at The Karmanos Cancer Institute in Detroit Identify Potential New Target for Breast Cancer Therapy
3. Scientists Discover a Role for the Growth Factor TGF-beta in Maintaining Health of Retinal Blood Vessels
4. Scientists Discover Why Teeth Form in a Single Row
5. Scientists Unmask Genetic Markers Associated With Psoriasis
6. 42 Top U.S. Scientists and Specialists Explore Cutting-Edge Innovations to Defend America From Dangerous Zoonotic Diseases
7. Gene Found Activated in 70% of Prostate Cancer Cases, George Washington University Medical Center Scientists Report
8. Battelle Scientists Named on Patent for Making Oxygen From Light and Water
9. Scientists Reveal Roadmap to Brain Health That Can Be Passed Down to Future Generations: Exercise, Omega-3, Folic Acid, Vitamin B6, and Vitamin B12
10. Tengion Scientists Publish Key Preclinical Findings Demonstrating the Benefits of Organ Regeneration Vs. Repair
11. Brain Stem Cells Can Be Awakened, Say Schepens Scientists
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/3/2017)...  Eli Lilly and Company (NYSE: ... Phase 3 MONARCH 2 study showed that abemaciclib, ... combination with fulvestrant, significantly improved progression-free survival (PFS) ... with hormone-receptor-positive (HR+), human epidermal growth factor receptor ... or progressed after endocrine therapy (median PFS, 16.4 ...
(Date:5/30/2017)... May 30, 2017 DarioHealth Corp. (NASDAQ: DRIO), a leading ... today announced that it will be presenting at the 7th annual ... PT. Erez Raphael , CEO, of DarioHealth will be giving ... be held on June 6th & 7th, 2017 at the Luxe ... small / micro-cap space. About ...
(Date:5/29/2017)... 29, 2017  Cellect Biotechnology Ltd. (NASDAQ: ... enables the functional selection of stem cells, today provided ... first quarter ended March 31 st , 2017. ... in the first quarter of 2017," said Dr. Shai ... announced the treatment of the first blood cancer patient ...
Breaking Medicine Technology:
(Date:6/28/2017)... ... June 28, 2017 , ... Schneider Insurance ... assistance to clients in southern Montana, is announcing a focused charity effort to ... The outreach programs offered by Zoo Montana provide students with current knowledge on ...
(Date:6/28/2017)... ... June 28, 2017 , ... Designers ... to communities in northern Virginia and DC, is announcing a cooperative charity event ... with Alzheimer’s and other disorders that lead to memory impairment. , The Insight ...
(Date:6/27/2017)... ... 27, 2017 , ... Excel Medical, the leader in Next-Generation ... of Executive Vice President, Sales and Marketing. Finnegan is a widely known industry ... sales leadership. He has received industry recognition for innovations and new approaches to ...
(Date:6/27/2017)... PA and London UK (PRWEB) , ... June 27, 2017 , ... ... applying to a clinical study is whether they can trust the sponsor to pay ... it is vital that sponsors and CROs establish payment strategies that encourage sites to ...
(Date:6/27/2017)... ... 27, 2017 , ... Salucro, the cloud-based payment platform that ... hospitals and provider groups, has announced that it will now offer Parasail’s payment ... a San Francisco health-finance startup that has launched a series of tech-based products ...
Breaking Medicine News(10 mins):