Navigation Links
Schering-Plough's Investigational Oral Thrombin Receptor Antagonist Meets Primary Endpoint in a Newly Published Study
Date:3/12/2009

ment elevation acute coronary syndrome. Patients will be randomized to either placebo plus standard medical care (including aspirin or clopidogrel) or to TRA plus standard medical care. The Phase III TRA-CER trial uses the oral 40 mg loading dose and the 2.5 mg maintenance dose. The primary endpoint of the Phase III TRA-CER trial is the composite of cardiovascular death, MI, rehospitalization for ACS, urgent coronary revascularization or stroke. The key secondary endpoint is the composite of cardiovascular death, MI or stroke. Patients will be followed for a minimum of one year. This Phase III trial is being conducted by the Duke Clinical Research Institute, Durham, NC.

About the Thrombin Receptor Antagonist

The investigational antiplatelet TRA is being developed by Schering-Plough for the prevention and treatment of atherothrombotic events in patients with acute coronary syndrome and in those with prior myocardial infarction or stroke, as well as in patients with existing peripheral arterial disease.

The U.S. Food and Drug Administration (FDA) had previously granted Fast Track designation to the compound. Fast Track designation allows FDA to expedite review of drugs and biologics for serious or life-threatening conditions which demonstrate the potential to address unmet medical needs.

Thrombosis may result in partial or complete blockage of arteries in the heart, brain or periphery. This process is the underlying mechanism of most acute vascular events, including acute coronary syndromes (ACS), such as myocardial infarction (MI), and ischemic stroke, which are the leading causes of death. Platelets are activated at the site of atherosclerotic plaque rupture in arteries and release substances that initiate aggregation and clot formation, and thrombin is the most potent activator of platelets. Drugs that block platelet activation by other mechanisms, such as the thromboxane- or ADP-mediated pathway
'/>"/>

SOURCE Schering-Plough Corporation
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7

Related medicine technology :

1. ImQuest Submits Investigational New Product Application to the Food and Drug Administration to Initiate HIV Therapeutic Clinical Trials with IQP-0410
2. Daiichi Sankyo Initiates Phase III Trial of Its Investigational Factor Xa Inhibitor, DU-176b, in Patients With Atrial Fibrillation
3. Vical Receives Milestone Payment from Merck & Co., Inc. Triggered by Planned Initiation of Investigational Cancer DNA Vaccine Trial
4. Miami Jewish Home and Hospital, Berma Research Group and Segal Institute for Clinical Research Enrolling Local Patients in Study of Investigational Therapy to Treat Alzheimers Disease
5. Data From Investigational Use of PROCRIT(R) (Epoetin alfa) Presented at American Society of Nephrology Annual Meeting
6. Medarex Receives Milestone Payment for Investigational Antibody Targeting Integrin Receptors
7. Tibotec Presents Interim Findings for TMC435, an Investigational Genotype 1 Hepatitis C Treatment, at the AASLD Liver Meeting 2008
8. Sequella Presents Data on Synergy Between Investigational New TB Drugs SQ109 and TMC207
9. Sequoia Pharmaceuticals Presents In Vitro and First-in-Human Data Supporting Further Development of SPI-256, a Novel Investigational Protease Inhibitor
10. Millennium Presents New Data on Investigational Drugs for Novel Cancer Targets at EORTC-NCI-AACR Symposium
11. Berlin Hearts EXCOR(R) Pediatric Receives Unconditional Investigational Device Exemption (IDE) Approval
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/5/2015)... DUBLIN , May 05, 2015 Research ... announced the addition of the "Radiation Dose ... Analytics Software, Consulting Services), by Application (Computed Tomography, ... - Global Forecasts to 2020" report to ... management market is expected to grow at a ...
(Date:5/5/2015)... 2015  American Laboratory Trading, Inc. (ALT), the leading ... industry veteran Anggie Becorest as their new ... based out of the company,s San Diego ... the company,s west coast operations, diversifying the company,s offerings, ... has been the leader in the refurbished lab equipment ...
(Date:5/5/2015)... 2015 Isis Pharmaceuticals, Inc. (Nasdaq: ISIS ... million for the three months ended March 31, 2015 ... $22.6 million for the same period in 2014.  Isis, ... from milestone payments earned from its partners compared to ... Isis reported a loss from operations of $9.3 million ...
Breaking Medicine Technology:Radiation Dose Management (Dose Tracking, Monitoring, and Analytics Software, Consulting Services) Market - Global Forecasts to 2020 2Radiation Dose Management (Dose Tracking, Monitoring, and Analytics Software, Consulting Services) Market - Global Forecasts to 2020 3ALT Names Anggie Becorest Senior Vice President of Business Development 2Isis Reports Financial Results and Highlights for First Quarter 2015 2Isis Reports Financial Results and Highlights for First Quarter 2015 3Isis Reports Financial Results and Highlights for First Quarter 2015 4Isis Reports Financial Results and Highlights for First Quarter 2015 5Isis Reports Financial Results and Highlights for First Quarter 2015 6Isis Reports Financial Results and Highlights for First Quarter 2015 7Isis Reports Financial Results and Highlights for First Quarter 2015 8Isis Reports Financial Results and Highlights for First Quarter 2015 9Isis Reports Financial Results and Highlights for First Quarter 2015 10Isis Reports Financial Results and Highlights for First Quarter 2015 11Isis Reports Financial Results and Highlights for First Quarter 2015 12Isis Reports Financial Results and Highlights for First Quarter 2015 13
... SOUTH SAN FRANCISCO, Calif., May 6, 2011 Onyx Pharmaceuticals, ... will present at the Bank of America Merrill Lynch Health ... Eastern Time (10:30 a.m. Pacific Time).   Interested ... our website at: http://www.onyx-pharm.com/investors/event-calendar ...
... MOUNTAIN VIEW, Calif., May 6, 2011 Hotspur ... CE Mark approval for the IQCath Balloon Dilatation ... technology to markets outside of the United States. ... combine multiple functions into a single device that ...
Cached Medicine Technology:Onyx Pharmaceuticals to Present at the Bank of America Merrill Lynch Health Care Conference 2Hotspur Technologies’ IQCath Catheter Receives CE Mark 2Hotspur Technologies’ IQCath Catheter Receives CE Mark 3
(Date:5/5/2015)... Alachua, FL (PRWEB) May 05, 2015 ... technology company focused on the $1.6 billion peripheral nerve ... the first quarter ended March 31, 2015 compared to ... “The market’s continued adoption of our proprietary portfolio of ... Nerve Connector and AxoGuard® Nerve Protector – and our ...
(Date:5/5/2015)... The 2015 Crystal Ball, hosted by the ... global research, outreach and patient advocacy programs. The gala evening ... that attracted hundreds of supporters. , The 2015 gala was ... hepatitis B virus (HBV) by Dr. Baruch S. Blumberg, who ... in Medicine for his discovery of the virus in 1976. ...
(Date:5/5/2015)... 05, 2015 Baptist Medical Center Jacksonville’s ... Cancer (CoC) of the American College of Surgeons. , ... meet more than 30 Commission on Cancer quality care ... process, and maintain levels of excellence in the delivery ... choose to seek care locally at a CoC-accredited cancer ...
(Date:5/5/2015)... " QuickPick Travel ” was featured on ... a look small, medium, and large businesses making an impact ... a business expert, conducted the business review and shared with ... to three weeks of vacation for free. , Vacations are ... explore the world. And when people are preparing for vacations, ...
(Date:5/5/2015)... 05, 2015 ProTexting, LLC – ... to deploy Mobile Engagement Campaigns and other Mobile solutions, ... clients can now leverage the power of Mobile Marketing ... syncing subscribers’ e-mail addresses into the Constant Contact Platform. ... that the growing trend of multi-channel marketing would become ...
Breaking Medicine News(10 mins):Health News:AxoGen, Inc. Reports 58% Year-Over-Year Revenue Growth for the 2015 First Quarter 2Health News:AxoGen, Inc. Reports 58% Year-Over-Year Revenue Growth for the 2015 First Quarter 3Health News:AxoGen, Inc. Reports 58% Year-Over-Year Revenue Growth for the 2015 First Quarter 4Health News:Hepatitis B Foundation Marks 50th Anniversary of HBV Discovery at its Crystal Ball Gala 2Health News:Hepatitis B Foundation Marks 50th Anniversary of HBV Discovery at its Crystal Ball Gala 3Health News:Baptist Medical Center Jacksonville Receives National Cancer Reaccreditation 2Health News:Baptist Medical Center Jacksonville Receives National Cancer Reaccreditation 3Health News:Baptist Medical Center Jacksonville Receives National Cancer Reaccreditation 4Health News:A Platform to Plan the Perfect Vacation was Featured on NewsWatch Television 2Health News:ProTexting SMS Mobile Marketing platform integrates with Constant Contact 2Health News:ProTexting SMS Mobile Marketing platform integrates with Constant Contact 3
... , Diabetes: A Deeper Look ... , DETROIT, Dec. 3 In the United States, a ... the Detroit Science Center will debut its newest exhibit, Diabetes: A ... about diabetes, diabetes treatment and the role insulin plays in the body. ...
... , WASHINGTON, Dec. 3 The Redwood Gazette ... struggling financially and worried about paying for their medicines. The ... more than 6 million patients find programs providing prescription medicines for ... has access to information on more than 475 patient assistance programs, ...
... in solid organ transplants have been issued with expert advice ... the global H1N1 (swine flu) pandemic. The paper, ... also urges them to stay alert to the significant concerns ... even bird flu (H5N1), to develop into a strain with ...
... compulsive users also feel depressed or anxious when not online ... Chinese adolescents found that teens who are addicted to the ... teens. , The survey of 1,618 students aged 13 ... Guangzhou in Guandong Province found that about 16 percent said ...
... ... of surgical cases on the iPhone or iPod touch. Pop up menu’s and one touch exporting ... provider. , ... I-Surgery , a new iPhone application for surgery, can be used by surgeons, residents, surgical ...
... ... to cheer up children during the holidays with his self-published and illustrated books, “Little ... nationwide. , ... (PRWEB) December 3, 2009 -- Carlton Scott RN , hopes to bring holiday ...
Cached Medicine News:Health News:Interactive Traveling Diabetes Exhibit to Be Unveiled at Detroit Science Center 2Health News:Interactive Traveling Diabetes Exhibit to Be Unveiled at Detroit Science Center 3Health News:Interactive Traveling Diabetes Exhibit to Be Unveiled at Detroit Science Center 4Health News:Transplant infectious disease experts provide pandemic guidance 2Health News:Transplant infectious disease experts provide pandemic guidance 3Health News:Teen Internet Addicts More Likely to Self-Harm: Study 2Health News:Traveling Nurse Cheers up Kids with Handmade Books 2Health News:Traveling Nurse Cheers up Kids with Handmade Books 3
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: