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Schering-Plough Reports Preladenant Meets Primary Endpoint in Phase II Dose-Finding Trial for Parkinson's Disease
Date:11/24/2008

vement disorders without some of the complications of standard dopaminergic treatments.

Parkinson's disease is an age-related, progressive, degenerative brain disease that currently affects one out of 100 people over the age of 60 (approximately 500,000 people in the U.S. alone). It is believed to be caused by a loss of nerve cells in the midbrain. The resulting symptoms include tremor, abnormal gait and posture, loss of balance, muscle stiffness and slowness of movements. These symptoms often severely compromise a patient's ability to lead a normal life. All currently available treatment options enhance directly or indirectly the effect of the neurotransmitter dopamine in the brain. While these treatments are often effective in the initial phase of the disease, their ability to control the symptoms of Parkinson's disease declines over time. Moreover, after several years of therapy these medications frequently induce additional troublesome and disabling motor fluctuations that can last several hours per day. At this stage, patients often experience periods of loss of movement control during the day (so-called "off"-time), which alternates with periods of relatively good motor functions (so-called "on"-time).

Schering-Plough is an innovation-driven, science-centered global health care company. Through its own biopharmaceutical research and collaborations with partners, Schering-Plough creates therapies that help save and improve lives around the world. The company applies its research-and-development platform to human prescription, animal health and consumer health care products. Schering-Plough's vision is to "Earn Trust, Every Day" with the doctors, patients, customers and other stakeholders served by its colleagues around the world. The company is based in Kenilworth, N.J., and its Web site is www.schering-plough.com.

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