Navigation Links
Schering-Plough Initiates Phase III Studies with Vicriviroc in Treatment- Experienced HIV Patients
Date:9/17/2007

s or need for dose adjustments based on the known vicriviroc drug-drug interaction profile. The studies will enroll approximately 375 patients each at more than 160 sites in North America, South America, Europe, Australia and South Africa.

"As a next-generation HIV entry inhibitor, vicriviroc has the potential to benefit a broad range of patients by offering a potent, sustained viral response and a single once-daily dose in combination with optimized background therapy," said Robert J. Spiegel, M.D., chief medical officer and senior vice president, Schering-Plough Research Institute. "There is an urgent need for new antiretroviral agents with novel mechanisms of action and we look forward to the further clinical evaluation of vicriviroc in these large global studies."

About the VICTOR-E3 and VICTOR-E4 Phase III Studies

VICTOR-E3 and VICTOR-E4 are identically designed, randomized, double- blind, placebo-controlled, parallel group, multicenter studies of vicriviroc in adult treatment-experienced patients infected with CCR5-tropic HIV virus (no detectable CXCR4-tropic or dual/mixed CCR5/CXCR4-tropic virus at screening).

The primary efficacy endpoint of the studies will be the proportion of patients with plasma HIV-1 RNA less than 50 copies/mL at week 48. Key secondary endpoints, each measured at 48 weeks, include the proportion of patients with less than 400 copies/mL of plasma HIV-1 RNA, mean change from baseline in plasma HIV-1 RNA (log10 copies/mL) and mean change from baseline CD4+ count. All efficacy endpoints will also be evaluated at week 24.

Patients in VICTOR-E3 and VICTOR-E4 must have documented resistance to at least two of the three antiretroviral drug classes (NRTI, NNRTI or PI)(2-4) or 6 months or more of experience with at least two of the following: one NRTI, one NNRTI or two PIs (excluding low-dose ritonavir); and must have plasma HIV- 1 RNA levels above 1000 copies/mL. The optimized background therapy must include a prote
'/>"/>

SOURCE Schering-Plough Corporation
Copyright©2007 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2 3 4

Related medicine technology :

1. Schering-Plough Announces Hepatitis C Data Presentations at Digestive Disease Week (DDW) 2007 Annual Meeting
2. Schering-Plough Addresses Major Milestones and Challenges in Treatment of Patients With Chronic Hepatitis C
3. Schering-Plough Announces Presentation of Phase II Trial Results for Novel Oral Thrombin Receptor Antagonist at the 2007 Annual Meeting of The American College of Cardiology/i2 Summit
4. Malvern initiates European user group meetings for chemical imaging
5. Data Available From Erbitux Phase III Study in First-Line Treatment of Advanced Lung Cancer
6. Phase 3 Results for Dabigatran Etexilate, an Investigational Oral Anticoagulant, Presented Today at the XXIst Congress of the International Society on Thrombosis and Haemostasis
7. YM BioSciences Announces Secondary Efficacy and Safety Findings in Randomized Phase IIB Aerolef Trial
8. Portola Pharmaceuticals Announces Positive Data from a Phase II Study of its Factor Xa Inhibitor at the XXI Congress of the International Society on Thrombosis and Haemostasis
9. Manhattan Pharmaceuticals Announces Results of Phase 2a Studies for Oral Oleoyl-estrone
10. Actemra (tocilizumab) Third Phase III Study Results Show Significant Improvement in Symptoms of Patients with Rheumatoid Arthritis
11. AVI BioPharma Partner Cook Medical Announces Completion of Patient Enrollment for APPRAISAL Phase II Clinical Trial for Treatment of Cardiovascular Disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/16/2009)... Dec. 16 Medlytix, a national healthcare ... a key half-billion dollar milestone - the total ... provided in financial assistance to more than a ... of properly classifying charity care - in less ... of these hospitals enhanced their bottom lines and ...
(Date:12/16/2009)... Texas, Dec. 16 Wound Management ... rapidly growing provider of specialty medical products, ... subsidiary is moving toward productization of its ... company currently anticipates products to be introduced ... estimated to be a multi-billion dollar international ...
(Date:12/16/2009)... -- Ethicon, Inc., a Johnson & Johnson (NYSE: ... leader in surgical care, and Acclarent, Inc., a ... developing and commercializing devices that address conditions affecting ... a definitive merger agreement whereby Ethicon will acquire ... million net of estimated cash on hand at ...
Breaking Medicine Technology:Healthcare Scoring System Allows Hospitals To Increase Charity Care 2Healthcare Scoring System Allows Hospitals To Increase Charity Care 3Healthcare Scoring System Allows Hospitals To Increase Charity Care 4Wound Management Technologies, Inc. Targets Multi-Billion Dollar Biomaterials Market; Releases Update on Resorbable Orthopedics 2Wound Management Technologies, Inc. Targets Multi-Billion Dollar Biomaterials Market; Releases Update on Resorbable Orthopedics 3Ethicon Announces Definitive Agreement to Acquire Acclarent 2Ethicon Announces Definitive Agreement to Acquire Acclarent 3Ethicon Announces Definitive Agreement to Acquire Acclarent 4EPA 3A Greenhouse Gases Hazardous to Your Health 62775 1EPA 3A Greenhouse Gases Hazardous to Your Health 62775 2EPA 3A Greenhouse Gases Hazardous to Your Health 62775 3Health Reform is About You and Me Not One or the Other 62773 1Health Reform is About You and Me Not One or the Other 62773 2Health Reform is About You and Me Not One or the Other 62773 3Oncologist at the Childrens Hospital of Philadelphia to Chair International Childhood Cancer Organization 62771 1Oncologist at the Childrens Hospital of Philadelphia to Chair International Childhood Cancer Organization 62771 2Oncologist at the Childrens Hospital of Philadelphia to Chair International Childhood Cancer Organization 62771 3Oncologist at the Childrens Hospital of Philadelphia to Chair International Childhood Cancer Organization 62771 4
(Date:12/17/2009)... Climate Conference in Copenhagen approaches its conclusion, negotiations ... mitigating climate change. The new ,Reducing Emissions from ... support as a central element of any new ... of global greenhouse gas emissions, this new policy ... contribution to emissions reduction. Linked to this, developed ...
(Date:12/17/2009)... Campaign Invites Personal Stories of Inspiration on How Exercise Has Helped, ... ... December 17, 2009 -- The International Health, Racquet & Sportsclub Association ... Healthier America, it is urging Americans of all ages and abilities ... to create a culture of movement in America wherein regular daily ...
(Date:12/17/2009)... screening within year of first intercourse , , THURSDAY, Dec. ... U.S. cities, about half acquire at least one of ... trichomoniasis -- within two years of becoming sexually active, ... 381 girls, aged 14 to 17, also found that ... infections. , "Depending on the organism, within four to ...
(Date:12/17/2009)... Master of Science in Human Resource Development Degree Online ... ... 2009 -- Open enrollment has begun for Villanova’s newly online ... working professionals whose busy schedules can’t accommodate a campus-based program. ... debuting online in March 2010, location is no longer a ...
(Date:12/17/2009)... DIEGO, Dec. 17 Neurocrine Biosciences, Inc. (Nasdaq: ... into a privately negotiated transaction to sell an aggregate ... affiliates of Venrock at a price of $2.09 per ... $10 million. Neurocrine expects the financing to close on ... conditions. ,, A shelf registration statement relating ...
Breaking Medicine News(10 mins):Health News:Forests take center stage at Copenhagen 2Health News:IHRSA's Campaign for a Healthier America Calls on All Americans to Curtail Health Care Costs in 2010 by Becoming Physically Active 2Health News:IHRSA's Campaign for a Healthier America Calls on All Americans to Curtail Health Care Costs in 2010 by Becoming Physically Active 3Health News:IHRSA's Campaign for a Healthier America Calls on All Americans to Curtail Health Care Costs in 2010 by Becoming Physically Active 4Health News:IHRSA's Campaign for a Healthier America Calls on All Americans to Curtail Health Care Costs in 2010 by Becoming Physically Active 5Health News:STDs Common Among Sexually Active Teen Girls in Cities 2Health News:A World-Class HR Master's Degree Is Now Within Reach – 100% Online 2Health News:A World-Class HR Master's Degree Is Now Within Reach – 100% Online 3Health News:Neurocrine Announces Sale of 4,784,689 Shares of Common Stock, to Raise Proceeds of $10 Million 2Health News:Neurocrine Announces Sale of 4,784,689 Shares of Common Stock, to Raise Proceeds of $10 Million 3
... Company, a life,and health insurance company, today announced ... product, ConsecoLifeOptions. The policy,provides upside potential with downside ... policy that offers the,opportunity for long-term cash buildup ... can customize their coverage levels with eight riders,that ...
... 29 The Custom Briefings,network of Bulletin News, ... Briefing, produced exclusively for the members of the ... Monday through Friday to over,14,000 Endocrine Society members, ... as diabetes and osteoporosis. Endocrine Daily,Briefing joins a ...
... Obama failed to address the issue, DENVER, ... Wednesday night, Former President Bill Clinton called,for a ... the,United States. In praising Presidential nominee Barack Obama, ... commendable global leadership in,an area in which I ...
... The following is a,statement by Matthew L. Myers, President, ... in a month, Philip Morris International has had to,withdraw ... country,after coming under international criticism for engaging in cigarette,marketing ... International has been forced to withdraw from,an August 30 ...
... chromosomal change that raises odds for malignancy, study finds ... survivors of the World War II atomic bomb blasts ... may have sparked the onset of a form of ... (PTC) is typically linked to a particular genetic mutation ...
... InterMune, Inc.,(Nasdaq: ITMN ) today announced that ... present at the Thomas Weisel Partners,Healthcare Conference in Boston ... To access a live audio webcast of the presentation, ... investor relations page of InterMune,s,corporate website at http://www.intermune.com ...
Other Medicine News:Health News:ConsecoLifeOptions Launched by Conseco Insurance Company as New Universal Life Product 2Health News:Custom Briefings Announces Launch of Endocrine Daily Briefing 2Health News:Bill Clinton and Other Leaders Call For 'Renewal of Battle Against AIDS' in the United States at Democratic Convention 2Health News:Bill Clinton and Other Leaders Call For 'Renewal of Battle Against AIDS' in the United States at Democratic Convention 3Health News:Philip Morris International Forced to Drop Another Concert Sponsorship; Philippines Health Department Applauded for Taking Action 2Health News:Some Hiroshima Survivors at Thyroid Cancer Risk 2Health News:Some Hiroshima Survivors at Thyroid Cancer Risk 3
... Catheter with Accutrol is similar in design ... that it incorporates a temperature probe at ... temperature probe can accurately determine the patient's ... provides temperature accuracy comparable to a pulmonary ...
... markers are available with 16 or 24 circular inner ... and an outer 9.5mm diameter. The markers are designed ... single step for a 16 or 24 running bite ... on the cornea to achieve a precise and rapid ...
... Ultra Micro Shafts For Insertion Through A ... Light-Weight ... Shafts For A More Comfortable Approach., ,Recessed ... Cap Supplied For Protection Of Jaws During ...
... advancements in diamond technology allow the incredible ... a more economical cost. Proven diamond blade ... insures a superior postoperative result. The knives ... a variety of widths and configurations. The ...
Medicine Products: