Navigation Links
Schering-Plough Highlights PEGINTRON(TM) and Boceprevir Hepatitis C Data Presentations at Digestive Disease Week (DDW) Annual Meeting
Date:5/15/2008

ificant adverse events have been reported at a frequency less than 1% with PEGINTRON or interferon alpha: Severe decreases in neutrophil or platelet counts, hypothyroidism, hyperglycemia, hypotension, arrhythmia, ulcerative and hemorrhagic colitis, development or exacerbation of autoimmune disorders including thyroiditis, RA, systemic lupus erythematosus, psoriasis, pulmonary disorders (dyspnea, pulmonary infiltrates, pneumonitis and pneumonia, some resulting in patient deaths), urticaria, angioedema, bronchoconstriction, anaphylaxis, retinal hemorrhages, and cotton wool spots.

In the PEGINTRON/REBETOL combination trial, the incidence of serious adverse events was 17% in the PEGINTRON/REBETOL groups compared to 14% in the INTRON A/ REBETOL group. The incidence of severe adverse events in the PEGINTRON/REBETOL combination therapy trial was 23% in the INTRON A/REBETOL group and 31-34% in the PEGINTRON/REBETOL groups. Dose reductions due to adverse reactions occurred in 42% of patients receiving PEGINTRON (1.5 mcg/kg)/REBETOL and in 34% of those receiving INTRON A/REBETOL.

In a study with weight-based ribavirin, there was a higher rate of anemia among patients in the weight-based dosing group (29%) compared to the flat- dosing group (19%). The majority of these cases were mild and responded to dose reductions. Serious adverse events were similar between the two groups (12%), and discontinuations for adverse events (15% in weight-based dosing and 14% in flat dosing) were also similar. Dose modifications due to adverse events occurred more frequently in the weight-based dosing group (29%) compared to the flat-dosing (23%) group.

Additional Safety Information

Relapse of drug addiction/overdose has occurred in patients on PEGINTRON therapy. Aggressive behavior sometimes directed towards others has occurred in patients with and without a previous psychiatric disorder during PEGINTRON and/or INTRON A treatment and follow-up. If patients develop ps
'/>"/>

SOURCE Schering-Plough Corporation
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7

Related medicine technology :

1. Schering-Plough Highlights PEGINTRON(TM) and Boceprevir Data Presentations at European Association for the Study of the Liver (EASL) Annual Meeting
2. Schering-Plough Announces Imperfect Contraceptive Use Impacts Womens Emotional Well-Being
3. Schering-Plough Initiates Phase II Study With Vicriviroc in Treatment-Naive HIV-Infected Patients
4. Parker Waichman Alonso LLP and Affiliated Lawfirms Have Filed a Class Action Lawsuit in the United States District Court for the Eastern District of New York Against Merck & Co., Inc. and Schering-Plough Corporation
5. Schering-Plough Reports Top-Line Results of the IDEAL Study
6. Schering-Plough Announces Asenapine NDA Accepted for Filing by the U.S. FDA
7. Schering-Plough Highlights PEGINTRON(TM) Clinical Data Presentations at the American Association for the Study of Liver Diseases (AASLD) 2007 Annual Meeting
8. Pharmacopeia Earns Milestone Payment From Schering-Plough on Initiation of Phase 1 Clinical Trials of Novel Therapeutic Candidate
9. Schering-Plough Initiates Phase III Studies with Vicriviroc in Treatment- Experienced HIV Patients
10. Genta Incorporated Announces Fourth Quarter and Year End 2007 Financial Results and Corporate Highlights
11. Sarasotas Roskamp Institute Highlights Positive Japanese Data that Validates its Ongoing Alzheimers Disease Research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/27/2015)... Concord Medical Services Holdings Limited ("Concord ... a leading specialty hospital management solution provider and ... diagnostic imaging centers in China ... agreement under which Concord Medical Services (International) Pte ... agreed to acquire the Fortis Surgical Hospital from ...
(Date:3/26/2015)... 2015 "Whether it,s our family, our friends, ... In a single sentence, Dr. Anthony Coyle ... Pfizer,s Centers for Therapeutic Innovation (CTI), sums ... at America,s biopharmaceutical companies. CTI,s unique ... patient foundations and the National Institutes of Health (NIH) ...
(Date:3/26/2015)... NEW YORK , March 26, 2015 /PRNewswire-USNewswire/ ... on the average American consumer. However, a new ... treating various ailments from the common cold to ... The research, conducted by the Private ... focused on over-the-counter healthcare products, including those essential ...
Breaking Medicine Technology:Concord Medical Announces Acquisition of Fortis Surgical Hospital in Singapore 2Concord Medical Announces Acquisition of Fortis Surgical Hospital in Singapore 3Collaboration for Cures: Teaming Up to Advance Science and Save Lives 2Consumers can keep over-the-counter medicine affordable by using store brands 2
... demonstrates dramatic,benefits of adding Diovan to conventional therapy , ... for,Diovan patients , , , BASEL,Switzerland, ... independent,Jikei Heart Study, published today in The Lancet[1], show ... produced a dramatic 39% reduction in,cardiovascular events and a ...
... - Journal of Clinical Oncology publishes first ... 27, 2007 /PRNewswire-FirstCall/ -- Human,Genome Sciences, Inc. ... to emerge demonstrating that its TRAIL receptor,antibodies, ... for use in the treatment of a ...
Cached Medicine Technology:Diovan Achieved 40% Reduction in Stroke and Cardiovascular Events,in Landmark Jikei Heart Study 2Diovan Achieved 40% Reduction in Stroke and Cardiovascular Events,in Landmark Jikei Heart Study 3Diovan Achieved 40% Reduction in Stroke and Cardiovascular Events,in Landmark Jikei Heart Study 4Diovan Achieved 40% Reduction in Stroke and Cardiovascular Events,in Landmark Jikei Heart Study 5Diovan Achieved 40% Reduction in Stroke and Cardiovascular Events,in Landmark Jikei Heart Study 6Diovan Achieved 40% Reduction in Stroke and Cardiovascular Events,in Landmark Jikei Heart Study 7Human Genome Sciences Reports Growing Evidence That Its TRAIL,Receptor Antibodies Have Significant Potential in the Treatment of,a Broad Range of Cancers 2Human Genome Sciences Reports Growing Evidence That Its TRAIL,Receptor Antibodies Have Significant Potential in the Treatment of,a Broad Range of Cancers 3Human Genome Sciences Reports Growing Evidence That Its TRAIL,Receptor Antibodies Have Significant Potential in the Treatment of,a Broad Range of Cancers 4Human Genome Sciences Reports Growing Evidence That Its TRAIL,Receptor Antibodies Have Significant Potential in the Treatment of,a Broad Range of Cancers 5
(Date:3/27/2015)... 2015 The report “CountryFocus Healthcare, ... essential source of information on and analysis of ... Germany’s increasingly elderly population and its associated disease ... In 2013, the elderly accounted for 27.1% of ... Annual Growth Rate (CAGR) of 1.2% to 29.5% ...
(Date:3/27/2015)... 27, 2015 On March 19, ... former Detroit Lions wide receiver Herman Moore, hosted ... presentation on substance abuse, treatment options and the ... attended were pastors, ministers and bishops from local ... distinguished guests. , “Our ‘Fighting Addiction Together’ luncheon ...
(Date:3/27/2015)... CA (PRWEB) March 27, 2015 SMI ... today announced it has launched the SM1120 MEMS based ... market. The microsensor profile at only 220um x ... maneuverability to reach challenging locations. With industry leading ... hour, the SM1120 provides a broad operating pressure range ...
(Date:3/27/2015)... March 27, 2015 Trail mix is the ... workout, on weekend hikes and during the game! It’s portable, ... Natural is proud to introduce a new line of specialty ... Deliciously rich and flavorful selections packed with nutritious, 100% all ... fruit and grains that add protein and fiber to your ...
(Date:3/27/2015)... Jersey (PRWEB) March 27, 2015 Airy ... has released the official music video for her debut ... , Combining live-action and abstract styling effects, the ... be viewed on YouTube, Vimeo, and assorted outlets. It ... the development of an expanding full-scale marketing strategy. The ...
Breaking Medicine News(10 mins):Health News:Germany Healthcare, Regulatory and Reimbursement Landscape Market Research Report Available at RnRMarketResearch.com 2Health News:Germany Healthcare, Regulatory and Reimbursement Landscape Market Research Report Available at RnRMarketResearch.com 3Health News:Germany Healthcare, Regulatory and Reimbursement Landscape Market Research Report Available at RnRMarketResearch.com 4Health News:LiveToBeSober.org Hosts Conference on Substance Abuse Treatment and Recovery at Ford Field 2Health News:SMI Launches Catheter Mountable Pressure Sensor 2Health News:Aurora Product, Inc. Introduces New Line of Specialty Trail Mixes 2Health News:Airy Jeanine Releases ‘’Mama’s Girl” Official Music Video 2
... can increase the risk of an acute attack of pancreatitis, but ... according to a study published online by BJS, the British ... in Sweden followed 84,601 people from 46 to 84 years of ... median of ten years. During that time 513 developed acute pancreatitis. ...
... , WEDNESDAY, Aug. 3 (HealthDay News) -- First they spread ... newly identified bacterium are infecting residents of the midwestern United ... will likely appear in other areas of the country. ... fatigue, has been identified in 25 people in Minnesota ...
... ITHACA, N.Y. U.S. physicians spend nearly $61,000 more ... related to health insurance, according to a new study ... Toronto. The study, published in the August issue ... per-physician costs in the U.S. averaged $82,975 annually, while ...
... (HealthDay News) -- Pregnant women who take ongoing, high doses ... increased risk of having babies with birth defects, the U.S. ... used to treat yeast infections of the vagina, mouth, throat, ... caused by a certain type of fungus and to prevent ...
... Jenifer Goodwin HealthDay Reporter , WEDNESDAY, Aug. ... for certain markers in the blood called "autoantibodies" is ... The blood test correctly detected Alzheimer,s disease in people ... percent accuracy, according to the researchers. The test could ...
... The Gerontological Society of America (GSA) the nation,s largest ... the National Center for Creative Aging (NCCA) have chosen Barry ... the 2011 recipient of the Gene D. Cohen Research Award ... the seminal work of Gene Cohen, MD, whose research in ...
Cached Medicine News:Health News:Drinking just 1 measure of spirits increases the risk of acute pancreatitis 2Health News:New Tick-Borne Illness Infects Midwesterners 2Health News:New Tick-Borne Illness Infects Midwesterners 3Health News:US physicians spend nearly 4 times more on health insurance costs than Canadian counterparts 2Health News:High Dose of Yeast Infection Drug Linked to Birth Defects, FDA Says 2Health News:Another Blood Test for Alzheimer's Shows Promise 2Health News:Another Blood Test for Alzheimer's Shows Promise 3Health News:Another Blood Test for Alzheimer's Shows Promise 4Health News:Bittman to receive 2011 Gene D. Cohen Award 2
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: