Navigation Links
Schering-Plough Highlights Hepatitis C Clinical Data Presentations at the European Association for the Study of the Liver (EASL) Annual Meeting
Date:4/26/2009

y profile for PEGINTRON was similar to that in previous studies; however, there were more serious infections in the treatment group (25 vs. 3), although these were not linked to neutropenia. None were unexpected events, nor was there a pattern to them.

In the primary analysis, PEGINTRON maintenance therapy was not superior to observational control in preventing the occurrence of clinical events. However, there was a statistically significant reduction in clinical events of hepatic decompensation on protocol-defined secondary analysis as well as in subjects with pre-existing esophageal varices.

Extended Treatment Duration in Chronic Hepatitis C Genotype 1-Infected Slow Responders: Final Results of the SUCCESS Study(2)

The primary objective of the SUCCESS study was to evaluate the effect of extending treatment duration to 72 weeks with PEGINTRON and REBETOL(R) (ribavirin, USP) combination therapy in genotype 1-infected patients who have slow response to therapy, defined as having detectable virus (HCV RNA) with at least a 2 log10 reduction in viral load at treatment week 12 and undetectable virus at treatment week 24. In this large, prospective, randomized, multinational clinical trial, slow responders were randomized at treatment week 36 to receive PEGINTRON combination therapy for a total of 48 weeks (n=86) (standard approved duration) or 72 weeks (n=73). Patients with undetectable virus at week 12 (complete early virologic response), received treatment for 48 weeks (n=816), whereas patients who did not respond to treatment (less than a 2 log10 reduction in viral load at week 12) were discontinued from the study. In total, 1,419 patients were treated.

In this study, sustained virologic response (SVR)(3) with 72-week treatment was not statistically superior to the 48-week treatment in slow responders (47.9 percent (35/73) vs. 43.0 percent (37/86), respectively), the primary endpoint of the
'/>"/>

SOURCE Schering-Plough Corporation
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8 9 10 11

Related medicine technology :

1. Schering-Plough Initiates Phase III Studies with Vicriviroc in Treatment- Experienced HIV Patients
2. Pharmacopeia Earns Milestone Payment From Schering-Plough on Initiation of Phase 1 Clinical Trials of Novel Therapeutic Candidate
3. Schering-Plough Highlights PEGINTRON(TM) Clinical Data Presentations at the American Association for the Study of Liver Diseases (AASLD) 2007 Annual Meeting
4. Schering-Plough Announces Asenapine NDA Accepted for Filing by the U.S. FDA
5. Schering-Plough Reports Top-Line Results of the IDEAL Study
6. Parker Waichman Alonso LLP and Affiliated Lawfirms Have Filed a Class Action Lawsuit in the United States District Court for the Eastern District of New York Against Merck & Co., Inc. and Schering-Plough Corporation
7. Schering-Plough Initiates Phase II Study With Vicriviroc in Treatment-Naive HIV-Infected Patients
8. Schering-Plough Announces Imperfect Contraceptive Use Impacts Womens Emotional Well-Being
9. Schering-Plough Highlights PEGINTRON(TM) and Boceprevir Data Presentations at European Association for the Study of the Liver (EASL) Annual Meeting
10. Schering-Plough Highlights PEGINTRON(TM) and Boceprevir Hepatitis C Data Presentations at Digestive Disease Week (DDW) Annual Meeting
11. Schering-Plough To Initiate Phase III Studies With HCV Protease Inhibitor Boceprevir in Previously Untreated Hepatitis C Patients and Those Who Failed Prior Treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/24/2015)... 24, 2015 Research and Markets ( ... "Global Biobanking Market 2015-2019" report to their offering. ... to grow at a CAGR of 7.07% over the ... be divided into two segments: Equipment and Consumables. This ... of the Global Biobanking market for the period 2015-2019. ...
(Date:4/24/2015)... -- Introduction of new "Elements" ... for radiosurgery/SBRT   The "Elements" strategy ... the workflow for difficult to treat indications in ... comes full circle with the introduction of automated ... enable on-the-fly generation of consistent treatment plans for ...
(Date:4/24/2015)... April 24, 2015 The National Institute ... the National Institutes of Health [NIH])  provided grants ... projects for the development of diagnostic tests for ... outbreaks at U.S. health facilities , the NIAID ... rapid, multiplexed and effective tests using alternative methods ...
Breaking Medicine Technology:Global Biobanking Market Report 2015-2019 - Increase in Strategic Collaborations with Beckman Coulter, Tecan & Thermo Fischer Scientific Dominating 2Brainlab Introduces New Generation of VMAT* for Brain and Spine at 3rd ESTRO in Barcelona 2Kalorama: NIAID Rewards HAI Innovators with Grants 2Kalorama: NIAID Rewards HAI Innovators with Grants 3Kalorama: NIAID Rewards HAI Innovators with Grants 4
(Date:4/25/2015)... 2015 Gardant Management Solutions will ... and operations, and sales and marketing at the ... to be held from April 29 through May ... the largest eldercare association in Illinois. The statewide ... older adults, including senior housing, assisted living and ...
(Date:4/25/2015)... OR (PRWEB) April 25, 2015 Sports controversies continue ... within team confines, as was the case with the Miami Dolphins ... team as seen in the Ray Rice domestic abuse case. In ... of Sporting News discusses the implications of locker room culture ... response and what other teams should do to improve the locker ...
(Date:4/24/2015)... Bird B Gone, the leader in bird ... a complete line of bird control solutions to address the ... Flu Strains Threaten Pacific, Central and Mississippi Farms , According ... a number of highly pathogenic avian flus in the Pacific, ... spread when wild birds enter poultry farms. The USDA urges ...
(Date:4/24/2015)... 24, 2015 As the nation recognizes ... unique sacrifices of these young men and women, the ... Veterans and their Families” presents a special training session ... to gain a better understanding of the effect of ... For those – civilian and military – who provide ...
(Date:4/24/2015)... 2015 The Fastest Fat Loss Week Ever, ... success of the Xtreme Fat Loss Diet, has been causing ... loss blueprint that claims to help one lose belly fat ... Stan Stevenson, prompting an investigative review. , "Our Fastest ... spent years researching and experimenting with these methods on their ...
Breaking Medicine News(10 mins):Health News:Gardant Management Solutions Staff Shares Operational Expertise 2Health News:David Steele Discusses Locker Room Culture on SCI TV 2Health News:David Steele Discusses Locker Room Culture on SCI TV 3Health News:Bird B Gone Offers Solutions to Bird Flu Threat to Poultry Farms 2Health News:Bird B Gone Offers Solutions to Bird Flu Threat to Poultry Farms 3Health News:Bird B Gone Offers Solutions to Bird Flu Threat to Poultry Farms 4Health News:Coalition Presents Resiliency Training to Raise Awareness during Month of the Military Child (#MOTMC2015) 2Health News:Fastest Fat Loss Week Ever Review Revealed on Healthy & Fit Zone 2
... The Central government of India plans to come out ... of technologies discovery by Indian universities //and research institutions ... ,The proposed legislation would give Indian universities and institutions ... CSIR the ability to stake claims on discoveries they ...
... more than $10 billion. The drug is prescribed ... of cardiovascular// disease and diabetes and those with ... conducting raids at some wholesale locations British authorities ... Lipitor . Officials are also contacting 20,000 pharmacy ...
... Researchers have discovered the protein that enables the malaria ... findings, which were published in the journal Cell, will ... disease of malaria.// ,A major pathway through which ... of a protein on the surface of merozoites called ...
... Cocoa compounds have various uses , it can be marketed ... pharmaceuticals.// ,Researchers now say they have been able ... and now have an impressive library of different flavonols. They ... those found in nature but also compounds tailored to specific ...
... be keeping patients on urinary catheters longer than necessary, ... infections, said a new study published in the Joint ... says that a simple reminder note put by the ... ,Research showed that about 25 percent of hospital ...
... extend the lifespan of many species through Sir2 gene.//, ... University of California, Davis, screened for genes that could ... study published today in the advance online edition of ... not live longer when subjected to calorie restriction, suggesting ...
Cached Medicine News:Health News:Researchers Discover Protein That Causes Malaria 2Health News:Patients Are Given Catheter Longer Than Necessary 2Health News:Genes to Extend Longevity Discovered 2
... developed in surgeon's desire to have the ... instrument with the strength to maneuver into ... bending or breaking. Arthrotek Hand Instruments are ... the surgeon's hand. This new generation of ...
... Arthrotek® Precision Hand Instruments were developed ... tactile feel, while still having an instrument ... spaces without the fear of the bending ... designed and manufactured to conform to the ...
... Precision Hand Instruments were developed in surgeon's ... while still having an instrument with the ... the fear of the bending or breaking. ... manufactured to conform to the surgeon's hand. ...
... Arthrotek® Precision Hand Instruments were developed in ... feel, while still having an instrument with ... without the fear of the bending or ... and manufactured to conform to the surgeon's ...
Medicine Products: