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Satori Pharmaceuticals to Present Data Highlighting Promise of Gamma-Secretase Modulators in Treatment of Alzheimer's Disease
Date:7/10/2012

CAMBRIDGE, Mass., July 10, 2012 /PRNewswire/ -- Satori™ Pharmaceuticals, a company dedicated to developing life-changing therapeutics for Alzheimer's disease (AD), today reported that three abstracts related to the use of gamma-secretase modulators (GSM) in the treatment of AD will be presented at the Alzheimer's Association International Conference (AAIC), being held July 14-19, 2012 in Vancouver, British Columbia.

"These studies add to the growing body of evidence that suggests gamma-secretase modulators are unique compounds that have great potential to be promising new therapies for the treatment of Alzheimer's disease," said Jeff Ives, Ph.D., CEO and Board Member of Satori Pharmaceuticals. "We look forward to sharing our data at AAIC."

Details of Satori's presentations are as follows:

Oral Presentation Title:  Satori gamma-secretase modulators are efficacious in wild type rodents following either acute or steady-state dosing   Session Date and Time:  Sunday, July 15, 2012, 3:30 to 5 p.m.   Presentation Number:  O1-11-01

Poster Sessions  Title:  An improved cell-based method for determining the gamma-secretase enzyme activity against both NOTCH and APP substrates  Session Date and Time:  Monday, July 16, 2012, 1 to 3 p.m.   Presentation Number:  P2-095

Title: Pharmacokinetic properties of a Satori gamma-secretase modulator, SPI-1865, in multiple animal model systems  Session Date and Time:  Wednesday, July 18, 2012, 1 to 3 p.m.   Presentation Number:  P4-199

Please note that, pursuant to AAIC's policy, the abstracts for these presentations cannot be disclosed until the officially scheduled date and time of presentation.

About Satori's Gamma-Secretase Modulators   Alzheimer's disease is characterized by the formation of amyloid beta plaques in the brain. Plaques are primarily composed of two main forms of amyloid beta: AB40 and AB42. Satori's program aims to reduce the amount of AB42 in the brain by modulating gamma-secretase, thus lowering brain amyloid, plaque formation and associated damage to normal neuronal function. Studies have demonstrated Satori's proprietary class of gamma-secretase modulators (GSMs) achieve a reduction in AB42 levels without altering total amyloid beta levels in cell lines and animal models of the disease.

About Satori™ Pharmaceuticals  Satori Pharmaceuticals is developing life-changing therapeutics for Alzheimer's disease. Driven by a world-class team of drug development veterans and advisors, Satori is advancing best-in-industry medicines that aim to slow or stop disease progression. Our drug candidates selectively modulate gamma secretase, the enzyme generating the neurotoxic peptides that form amyloid beta plaques – the signature of this debilitating disease. For more information, visit www.satoripharma.com.


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