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Santaris Pharma A/S Expands Executive Team, Appoints Chief Medical Officer and Chief Business Officer to Advance Proprietary RNA-targeted Drug Development Programs
Date:10/28/2009

$100 M venture capital affiliate of Amgen Inc. with approximately 15 portfolio companies. He had also been responsible for Amgen's in- and outlicensing transactions group and Amgen's Corporate Alliance Management function. Mr. Mackey received his undergraduate degree from Harvard University and his law degree from the University of California, Berkeley's Boalt Hall School of Law.

Recent scientific and business accomplishments at Santaris Pharma A/S include a breakthrough in medical science and new collaborations. Santaris Pharma A/S is the first company to advance a microRNA-targeted therapy into human clinical trials. The drug SPC3649 specifically targets microRNA-122 (miR-122), a host factor for Hepatitis C virus replication. A single-dose Phase 1 trial in healthy volunteers has been completed and the drug continues to move forward in clinical trials.

Santaris Pharma A/S recently announced a multi-year worldwide strategic alliance with Shire plc to discover and develop new RNA-targeted medicines to treat rare genetic disorders. This collaboration adds to the growing list of mRNA and microRNA drug discovery and development partnerships, which includes Wyeth (delivery of lead candidates against up to ten targets), GlaxoSmithKline (four viral disease drug candidates) and Enzon Pharmaceuticals (eight cancer targets successfully delivered).

About Locked Nucleic Acid (LNA) Drug Platform

The Locked Nucleic Acid (LNA) Drug Platform developed by Santaris Pharma A/S creates synthetically modified chemical versions of the normal nucleic acid building blocks of ribonucleic acids (RNA). These modified chemical versions called LNAs improve the drug-like qualities of resulting therapeutics (oligonucleotides) by boosting resistance to metabolism, increasing half-life and improving tissue uptake. LNA-based therapeutics demonstrate improved binding affinity to their target RNA, which increases pot
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