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Sanofi-aventis and Sunnybrook Health Sciences Centre Agree to Develop Treatment for Diabetic Foot Ulcers
Date:2/15/2011

s. We are grateful that our commercialization agent MaRS Innovation identified sanofi-aventis as the ultimate partner, and we are committed to working with sanofi-aventis to help us develop vasculotide further."

Vasculotide is a synthetic peptide-based growth factor that targets Tie-2, a receptor on specialized cells of the hematopoietic and vascular systems. Close to two decades ago, Dr. Dumont and his colleagues were the first to discover and detail the importance of Tie-2 and its role in the formation of blood vessels. Dumont and Van Slyke are now investigating the use of vasculotide for restoring vascular health and accelerating healing during wound repair. Vasculotide may provide a shortcut to the series of molecular activities involved in blood vessel growth that ultimately lead to wound closure, which may improve healing in patients.  

Under the terms of the agreement, sanofi-aventis has an exclusive worldwide option with predetermined upfront milestones and royalty payments with Sunnybrook to develop and commercialize vasculotide. The agreement was signed through Sunnybrook with the assistance of its commercialization agent MaRS Innovation. Financial terms of this agreement were not disclosed.

About Angiogenic CompoundsAngiogenesis is a physiological process involving the growth of new blood vessels from pre-existing vessels and is an essential process to wound healing and combating diseases characterized by either poor vascularization or abnormal vasculature. Several diseases, such as ischemic chronic wounds, are the result of failure or insufficient blood vessel formation and may be treated by angiogenic compounds that foster local expansion and/or stabilization of blood vessels, thus bringing new nutrients to the site and facilitating repair.  

About Neuropathic and Neuroischemic Diabetic Foot UlcersFoot ulcers are a frequent cause of morbidity and mortality i
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