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Sanofi-aventis Oncology Data to be Presented at San Antonio Breast Cancer Symposium
Date:12/9/2010

with gemcitabine and carboplatin in the MDA-MB-468 (-) Triple Negative Breast Cancer (TNBC) cell lineIniparib Data:Abstract # P6-15-01

Gene pathway analysis of

primary TNBC tumors

Sunday, Dec. 12

7:00 - 8:30 AM CSTData from a preclinical study characterizing the pathways of  primary human triple-negative breast cancersAbout Iniparib (BSI 201)Iniparib (BSI-201), the United States Adopted Name (USAN) for BSI-201, is a novel investigational small molecule with poly (ADP-ribose) polymerase (PARP) inhibitory activity.

BiPar Sciences and sanofi-aventis are pursuing a broad development program with iniparib in breast cancer and multiple trials are planned to start in the next several months.  A Phase 3 trial in mTNBC is ongoing, and multiple new trials are planned to start in the next several months.  New trials include:

  • A Phase 2 trial in HER2-/Hormone receptor positive (ER+ and/or PR+) metastatic breast cancer
  • A Phase 1b/2 trial in HER2- metastatic breast cancer (combination with taxane chemotherapy)
  • A Phase 2 trial in mTNBC testing the Taxotere/Cytoxan chemotherapy combination

  • Iniparib also in being studied in a Phase 3 trial for patients with squamous non-small cell lung cancer, and in Phase 2 trials for patients with ovarian, uterine and brain cancers.  The regulatory submissions are planned for Q1 2011 in the U.S. and Q2 2011 in the European Union.  

    About Taxotere (docetaxel) Injection ConcentrateIntroduced more than 14 years ago, Taxotere is approved for use in the following indications:

    Breast Cancer:  

  • TAXOTERE is indicated for the treatment of patients with locally advanced or metastatic breast cancer after failure of prior chemotherapy
  • TAXOTERE in combination with doxorubicin and cyclophosphamide is indicated for the adjuvant treatment of patients with operable node-positive breast cancer

  • Non-Small Cell L
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